DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6k and Sgk3

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001362972.1	Gene:	Sgk3 / 171498	RGDID:	620242	Length:	496	Species:	Rattus norvegicus

Alignment Length:	413	Identity:	166/413 - (40%)
Similarity:	235/413 - (56%)	Gaps:	53/413 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SDPSELFDLELHDLELQDDKARDSDDDRIELDDVDLEPELCINLHQDTEGQETIQLCEENVNPGK 69
            |||||            |:..|.:........:::|.|                        .|.
  Rat   126 SDPSE------------DEDERSTPKPHSTSRNINLGP------------------------TGN 154

  Fly    70 IKLGPKDFELKKVLGKGGYGKVFQV-RKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNI- 132
            ....|.||:..||:|||.:|||... ||..|    |::|:|||:| .||.|:|:..|..||||:
  Rat   155 PHAKPSDFDFLKVIGKGSFGKVLLAKRKLDG----KFYAVKVLQK-KIVLNRKEQKHIMAERNVL 214

  Fly   133 LEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHK 197
            |:.|||||:|.|.|:|||..|||.:|::::|||||.||:||..|.|....||.:||..|||:||.
  Rat   215 LKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEPRARFYAAEIASALGYLHS 279

  Fly   198 LGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDW 262
            :.|:||||||||||||:.|||.|||||||||.|.....|.|||||.||:|||::.:..:...|||
  Rat   280 IKIVYRDLKPENILLDSMGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDW 344

  Fly   263 WSLGALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPE 327
            |.|||::::||.|:|||...:..:..:.||...|||...::..|..::..|:::....|||: .|
  Rat   345 WCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLNLRPGVSLTAWSILEELLEKNRQNRLGA-KE 408

  Fly   328 DAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQ-IPVD---SPDDTTLSE 388
            |...:|.||||:.::|.|::.:::.||..|.:...||:..||..||.: :|..   |.|.:.::.
  Rat   409 DFLEIQNHPFFESLSWTDLVQKKIPPPFNPNVAGPDDIRNFDAVFTEETVPYSVCVSSDYSIVNA 473

  Fly   389 S---ANLIFQGFTYVAPSILEDM 408
            |   |:..|.||:|..||  ||:
  Rat   474 SVLEADDAFVGFSYAPPS--EDL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	148/329 (45%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	149/329 (45%)
Sgk3	NP_001362972.1	PX_CISK	12..120	CDD:132780
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..157		10/66 (15%)
		STKc_SGK3	165..490	CDD:270755	149/330 (45%)
		Nuclear localization signal. /evidence=ECO:0000250	195..205		5/10 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810