Protein Alignment S6k and Akt2

DIOPT Version :10

• Sequence 1: NP_523941.2
• Gene: S6k / 38654
• FlyBaseID: FBgn0283472
• Length: 490
• Species: Drosophila melanogaster
• Sequence 2: NP_031460.1
• Gene: Akt2 / 11652
• MGIID: 104874
• Length: 481
• Species: Mus musculus
• Alignment Length: 401
• Identity: 167/401 - (41%)
• Similarity: 238/401 - (59%)
• Gaps: 31/401 - (7%)

  Fly    27 DSDDDRIE-LDDVDLEPELCINLHQDTEGQE-------------TIQLCEENVNPGKIKLGPKDF 77
            ||.|:|.| :..:.:   :..:|.|...|::             |.::.|..||..:.|:...||
Mouse    91 DSPDEREEWMRAIQM---VANSLKQRGPGEDAMDYKCGSPSDSSTSEMMEVAVNKARAKVTMNDF 152

  Fly    78 ELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFIV 142
            :..|:||||.:|||..||:.|   ..:|:|||:|:|..|:. :.:.|||..|..:|:..:|||:.
Mouse   153 DYLKLLGKGTFGKVILVREKA---TGRYYAMKILRKEVIIA-KDEVAHTVTESRVLQNTRHPFLT 213

  Fly   143 ELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKP 207
            .|.|||||..:|..::||.:|||||.||.||.:|.||...||.:||:.||.:||...::|||:|.
Mouse   214 ALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVSALEYLHSRDVVYRDIKL 278

  Fly   208 ENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDM 272
            ||::||..||:|:||||||||.|.:|....|||||.||:|||:|..:.:|:|||||.||.:|::|
Mouse   279 ENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEM 343

  Fly   273 LTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPF 337
            :.|..||..::.::..|.||..::..|..|.|||:.|:..|:|:...||||.||.||..|..|.|
Mouse   344 MCGRLPFYNQDHERLFELILMEEIRFPRTLGPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRF 408

  Fly   338 FKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQ-IPV------DSPDDTTLSESANLIFQ 395
            |..:||.||:.::|.||.||.:.||.|...||..||.| |.:      ||.|...|.:..:  |.
Mouse   409 FLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLDPLELDQRTH--FP 471

  Fly   396 GFTYVAPSILE 406
            .|:|.| ||.|
Mouse   472 QFSYSA-SIRE 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_523941.2	STKc_p70S6K	81..402	CDD:270736	148/327 (45%)
Akt2	NP_031460.1	PH_PKB	4..111	CDD:269947	5/22 (23%)
		STKc_PKB_beta	156..478	CDD:173686	149/328 (45%)