DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6k and Akt1

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	NP_001159366.1	Gene:	Akt1 / 11651	MGIID:	87986	Length:	488	Species:	Mus musculus

Alignment Length:	337	Identity:	150/337 - (44%)
Similarity:	213/337 - (63%)	Gaps:	8/337 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DTEGQETIQLCEENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKAS 115
            |..|.|.:   |.::...|.::...:||..|:||||.:|||..|::.|   ..:|:|||:|||..
Mouse   127 DNSGAEEM---EVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA---TGRYYAMKILKKEV 185

  Fly   116 IVTNQKDTAHTRAERNILEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDT 180
            ||. :.:.|||..|..:|:..:|||:..|.|:|||..:|..::||.:|||||.||.||.:|.||.
Mouse   186 IVA-KDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDR 249

  Fly   181 TCFYLSEIILALGHLH-KLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIE 244
            ..||.:||:.||.:|| :..::|||||.||::||..||:|:||||||||.|::|....|||||.|
Mouse   250 ARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPE 314

  Fly   245 YMAPEILTRSGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDL 309
            |:|||:|..:.:|:|||||.||.:|::|:.|..||..::.:|..|.||..::..|..|.|||:.|
Mouse   315 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSL 379

  Fly   310 VRRLMKRQEPQRLGSGPEDAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTR 374
            :..|:|:...||||.|.|||..:..|.||.::.|.||..::|.||.||.:.||.|...||..||.
Mouse   380 LSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTA 444

  Fly   375 QIPVDSPDDTTL 386
            |:...:|.|..|
Mouse   445 QMITITPPDQVL 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	145/312 (46%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	143/307 (47%)
Akt1	NP_001159366.1	PH_PKB	4..111	CDD:269947
		PH	6..104	CDD:278594
		Inositol-(1,3,4,5)-tetrakisphosphate binding. /evidence=ECO:0000250	14..19
		Inositol-(1,3,4,5)-tetrakisphosphate binding. /evidence=ECO:0000250	23..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..137		4/12 (33%)
		Pkinase	150..408	CDD:278497	124/261 (48%)
		STKc_PKB	154..466	CDD:270723	143/307 (47%)
		Inhibitor binding. /evidence=ECO:0000250	228..230		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840