DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6k and rps6ka6

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	XP_031748253.1	Gene:	rps6ka6 / 100488417	XenbaseID:	XB-GENE-487733	Length:	788	Species:	Xenopus tropicalis

Alignment Length:	406	Identity:	191/406 - (47%)
Similarity:	265/406 - (65%)	Gaps:	25/406 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ELHDLELQDDKARDSDDDRIELDDVDLEPELCINLHQDTEGQETIQLCEENVNPGKIKLGPKDFE 78
            ||:.|::.|:...:. :..:..|:.::: |:.|. |...||      ||        |..|..||
Frog    68 ELNGLKMMDEPMEEG-ESLLPYDEGNVK-EIQIT-HHVKEG------CE--------KADPAQFE 115

  Fly    79 LKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFIVE 143
            |.||||:|.:||||.|||..|.||.:.:|||||||||:  ..:|...|:.||:||..|.|||||:
Frog   116 LLKVLGQGSFGKVFLVRKIIGPDAGQLYAMKVLKKASL--KVRDRVRTKMERDILVEVNHPFIVK 178

  Fly   144 LVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPE 208
            |.|||||:|||||||::|.||::|..|.:|.:|.|:...|||:|:.|||.|||.|||:|||||||
Frog   179 LHYAFQTEGKLYLILDFLRGGDVFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIVYRDLKPE 243

  Fly   209 NILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDML 273
            |||||..||:|||||||.||.:......::||||:||||||::.|.||.::.||||.|.|||:||
Frog   244 NILLDEAGHIKLTDFGLSKESVDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEML 308

  Fly   274 TGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFF 338
            ||..||..::|.:|:..|||:||.:|.:|:|||:.|:|.|.||....|||:|.:....::.||||
Frog   309 TGTLPFQGKDRNETMNMILKSKLGMPQFLSPEAQSLLRMLFKRNPSNRLGAGLDGVEEIKRHPFF 373

  Fly   339 KHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESANLIFQGFTYVAPS 403
            ..::|:.:..|.::||.||.....:|...||..||.:.|.||| ....|.:|:.:|:||::||||
Frog   374 STIDWNKLYRREIQPPFKPASGKPEDTFCFDPEFTAKTPKDSP-GVPPSANAHQLFKGFSFVAPS 437

  Fly   404 ILEDMHR----ANRMP 415
            .:|: |:    ||.:|
Frog   438 SVEE-HKISSIANVLP 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	166/320 (52%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	166/320 (52%)
rps6ka6	XP_031748253.1	STKc_RSK_N	118..434	CDD:270734	165/318 (52%)
rps6ka6	XP_031748253.1	STKc_RSK4_C	463..758	CDD:271079
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010