DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment S6k and rps6ka3b

DIOPT Version :9

Sequence 1:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster
Sequence 2:	XP_009295647.1	Gene:	rps6ka3b / 100009657	ZFINID:	ZDB-GENE-070209-74	Length:	739	Species:	Danio rerio

Alignment Length:	398	Identity:	188/398 - (47%)
Similarity:	255/398 - (64%)	Gaps:	32/398 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DLEPELCINLHQDTEGQETIQLCEENVN-----------PGKIKLGPKDFELKKVLGKGGYGKVF 92
            :.||.   ::.:|:.|::....|:|.|:           .|..|..|:.|||:||||:|.:||||
Zfish    21 ETEPH---HVLEDSMGEDENLSCQEEVSVKEINITHLVKEGSEKADPQQFELRKVLGQGSFGKVF 82

  Fly    93 QVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPFIVELVYAFQTDGKLYLI 157
            .|:||.|.||.:.:||||||||::  ..:|...|:.||:||..|.|||||:|.|||||:||||||
Zfish    83 LVKKTTGPDAGQLYAMKVLKKATL--KVRDQVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLI 145

  Fly   158 LEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHVKLTD 222
            |::|.||:||..|.:|.:|.|:...|||:|:.|||.|||.||||||||||||||||..||:||||
Zfish   146 LDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDEDGHIKLTD 210

  Fly   223 FGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKT 287
            |||.||.|......::||||:||||||::.|.||..:.||||.|.||::||||..||..::||:|
Zfish   211 FGLSKESIDHENKAYSFCGTVEYMAPEVVNRRGHTYSADWWSYGVLMYEMLTGTLPFQGKDRKET 275

  Fly   288 IETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFFKHVNWDDVLARRLE 352
            :..||||||.:|.:|:.||:.|:|.|.||....|||:||:....::.|||:..::|:.:..|...
Zfish   276 MTMILKAKLGMPQFLSSEAQSLLRSLFKRNPTNRLGAGPDGVEEIKRHPFYVSIDWNKLFRRESH 340

  Fly   353 PPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESANLIFQGFTYVA---------------P 402
            ||.||.....||...||..||.:.|.||| ....|.:||.:|:||::||               .
Zfish   341 PPFKPATGRPDDTFYFDPEFTAKTPKDSP-GVPPSANANRLFRGFSFVAITSEEESQSLPSNSMS 404

  Fly   403 SILEDMHR 410
            ||::.:||
Zfish   405 SIVQQLHR 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	170/320 (53%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	171/335 (51%)
rps6ka3b	XP_009295647.1	S_TKc	67..325	CDD:214567	148/259 (57%)
		STKc_RSK_N	71..387	CDD:270734	169/318 (53%)
		PKc_like	403..739	CDD:304357	4/10 (40%)
		Pkinase	421..678	CDD:278497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573223
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.880