DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Bre1 and RNF40

DIOPT Version :9

Sequence 1:NP_001286950.1 Gene:Bre1 / 38652 FlyBaseID:FBgn0086694 Length:1044 Species:Drosophila melanogaster
Sequence 2:NP_001273501.1 Gene:RNF40 / 9810 HGNCID:16867 Length:1001 Species:Homo sapiens


Alignment Length:1096 Identity:471/1096 - (42%)
Similarity:659/1096 - (60%) Gaps:155/1096 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 SKRSADDATGSSCLVAAAAAGQPPIKKVH---------FEPHLIGPVSTLEEMDIKVLEFQNKKL 57
            :||:|.|. ||.          ||.||:.         .||..:|.:|:.||||:|||:|:||||
Human     6 NKRAAGDG-GSG----------PPEKKLSREEKTTTTLIEPIRLGGISSTEEMDLKVLQFKNKKL 59

  Fly    58 AQRIEQRMRTEAELRHRIEQLEKRQTQDDAVLNVVNRYWNQLNEDIRVLLQRFDAE----TADEL 118
            |:|:|||...|.|||.|||:|||||..|||.|.:|||||.||:|.:..||:..:::    :|.|.
Human    60 AERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLRCHESQGELSSAPEA 124

  Fly   119 ENRNE-----------------------------NEVTTSFLAQLSTWDKEELDEKLANRVQVSK 154
            ....|                             :|...:|:..|.....||::.:|..|::.||
Human   125 PGTQEGPTCDGTPLPEPGTSELRDPLLMQLRPPLSEPALAFVVALGASSSEEVELELQGRMEFSK 189

  Fly   155 RAVAKIVQVIDRLMQRNEKITHVLKGDSLASAGSGSGAGAGGEEEQQQASGDAETTTSSAGVHAL 219
            .||:::|:..|||.:|.|::.                       ::..:.||:|..:.:|..|..
Human   190 AAVSRVVEASDRLQRRVEELC-----------------------QRVYSRGDSEPLSEAAQAHTR 231

  Fly   220 EETLKQTHIEIMSENHKLQNLNTSLHEKFHTMSLKMKEYQDAHTAKETENAELKNQIDELQYDLE 284
                     |:..||.:||:|.|.|.||.|.:||:..|.||..|:.||:..|::..:::||:|:|
Human   232 ---------ELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSAETKVLEMETTVEDLQWDIE 287

  Fly   285 KIHCRNDKLENHLAEAIEKLKAYHQIYGDPNKSTNSAKTPTTTGSGGATTSVNSQLLEELQKELE 349
            |:..|..||..|||||:|:|.:.:.:.|            :::|..|...:::.|..|.|..|||
Human   288 KLRKREQKLNKHLAEALEQLNSGYYVSG------------SSSGFQGGQITLSMQKFEMLNAELE 340

  Fly   350 EYRELANNRLQELDKLHATHRETLKEVEKLKMDIRQLPESVIVETTEYKCLQSQFSVLYNESMQI 414
            |.:||||:|:.||:||.|..:..::..|:||:.:|.|||.|:.||.||:.||:|||:|||||:|:
Human   341 ENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQV 405

  Fly   415 KTMLDETRNQLQTSKNQHLRQIEVMESEELIAQKKVRSEMIQMEDVLALIRKEYETLRIEFEQNM 479
            ||.|||.|..|..:||.|||.||.|||:||..|||:|:|:||:||.||.:|||||.||||||||:
Human   406 KTQLDEARGLLLATKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNL 470

  Fly   480 AANEQTAPINREMRHLITSLQNHNGQLKGEVQRYKRKYKDTSTDNLKLRQELADA------LATL 538
            |||||..||||||||||:||||||.||||:.||||||.::...:..|||.:.:.:      |...
Human   471 AANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSAHSTPNLGHP 535

  Fly   539 EGNKLQAATGAAGEEIKQENSTGVKEENSNNVSASGQTNQTNSGNDTNVAIKEENHISAEDEADD 603
            |.:.:.|.  |.|:|..........:.........|.|..|.|       :|:|..:.:|::...
Human   536 EDSGVSAP--APGKEEGGPGPVSTPDNRKEMAPVPGTTTTTTS-------VKKEELVPSEEDFQG 591

  Fly   604 EASGKDVKDGIKQEKLSSGDAAAA----EKKDSPGPGNSTSSATNSVPVKNEKDSKDGVKGK--D 662
            ...|       .|...|.|....|    |.::..||      :....||.:.....|..|.|  :
Human   592 ITPG-------AQGPSSRGREPEARPKRELREREGP------SLGPPPVASALSRADREKAKVEE 643

  Fly   663 VKAVESETVRDLKAQLKKALNDQKEMKLLLDMYKGVSKDQRDKVQLMATEKKLRSEIEELRQQLK 727
            .|..|||.::.|:|:||||...||||||||||||...|:|||||||||.|:|.::|::|||.:::
Human   644 TKRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIR 708

  Fly   728 KLQESKREERKKLADEEALRKIKQLEEQKYELQKQMANHKPTDNSWGSGAPGTANYTRPFVGSHE 792
            :|:|..|.|.||:|||:|||:|:|.|||...||:::...|                       .|
Human   709 ELEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATK-----------------------QE 750

  Fly   793 EEALLNEMEVTGQAFEDMQEQNSRLIQQLREKDDANFKLMSERIKANQLHKLLREEKTVLEDQMA 857
            |||||:||:|||||||||||||.||:||||||||||||||||||||||:||||||||..|.:|:.
Human   751 EEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVL 815

  Fly   858 TATTQIEAMHIVLRKLEEKERSLQATVASIEKELMLRQQAMEMHKRKAIESAQSAADLKLHLEKY 922
            ...:|::|..:.::|||||||:||.::..:||||.||.||:|::||||:|:||.|.|||:.||..
Human   816 GLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHV 880

  Fly   923 HAQMKEAQQVVAEKTSSLEAEAYKTKRLQEELAQFKRKAERMKKMEMSGTTIDEVMIEEIREYKE 987
            ..:::|.|..:||..::.|.|::..||.||::::.:||.|:.:|:|:.... ||::.|||:|||.
Human   881 QTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADA-DEILQEEIKEYKA 944

  Fly   988 TLTCPSCKVKRKDAVLSKCFHVFCYDCLRTRYETRQRKCPKCNCAFGANDYHRLYL 1043
            .||||.|..::|||||:|||||||::|:|.|||.|||||||||.||||:|:||:|:
Human   945 RLTCPCCNTRKKDAVLTKCFHVFCFECVRGRYEARQRKCPKCNAAFGAHDFHRIYI 1000

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Bre1NP_001286950.1 SMC_prok_B <235..987 CDD:274008 346/763 (45%)
AAA_23 <654..762 CDD:290211 60/109 (55%)
zf-C3HC4_2 991..1029 CDD:290634 26/37 (70%)
RNF40NP_001273501.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32 10/36 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..146 3/29 (10%)
SMC_N 231..920 CDD:330553 339/754 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 518..652 32/155 (21%)
RING-HC_RNF40 945..999 CDD:319729 38/53 (72%)
RING-HC finger (C3HC4-type) 948..986 CDD:319729 26/37 (70%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155502
Domainoid 1 1.000 708 1.000 Domainoid score I121
eggNOG 1 0.900 - - E1_KOG0978
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H8856
Inparanoid 1 1.050 805 1.000 Inparanoid score I498
Isobase 1 0.950 - 0 Normalized mean entropy S3888
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D139233at33208
OrthoFinder 1 1.000 - - FOG0001777
OrthoInspector 1 1.000 - - oto90168
orthoMCL 1 0.900 - - OOG6_103285
Panther 1 1.100 - - LDO PTHR23163
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R146
SonicParanoid 1 1.000 - - X1307
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.740

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