DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bre1 and HUB2

DIOPT Version :9

Sequence 1:	NP_001286950.1	Gene:	Bre1 / 38652	FlyBaseID:	FBgn0086694	Length:	1044	Species:	Drosophila melanogaster
Sequence 2:	NP_564680.4	Gene:	HUB2 / 841968	AraportID:	AT1G55250	Length:	900	Species:	Arabidopsis thaliana

Alignment Length:	1118	Identity:	231/1118 - (20%)
Similarity:	425/1118 - (38%)	Gaps:	337/1118 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PIKKVHFEPHLIGPVSTLE----------------------------------EMDIKVLEFQNK 55
            |::|   :|||:..||...                                  ::|..||:.||:
plant     9 PMQK---KPHLLDSVSPNSMARNSSPSHPIAKSVSFFDCDFSLLCLRLVDYEIDVDATVLQLQNQ 70

  Fly    56 KLAQRIEQRMRTEAELRHRIEQLEKRQTQDDAVLNVVNRYWNQLNEDIRVLLQRFDAETADELEN 120
            ||.|:::.:.:...::..:|::|:..||..|..|..||:.||||.:|:.:|..|..|
plant    71 KLVQQLDLQKKQLYDVESKIQELQLNQTSYDDELISVNQLWNQLVDDLILLGVRAGA-------- 127

  Fly   121 RNENEVTTSFLAQLSTWDKEELDEKLANRVQVSKRAVAKIVQVIDRLMQRNEKITHVLKGDSLAS 185
               |:...::|        :.:|:|........:..:.:::||                 |||
plant   128 ---NQEALNYL--------DIVDKKRVPPCAADETFLCRLLQV-----------------DSL-- 162

  Fly   186 AGSGSGAGAGGEEEQQQASGDAETTTSSAGVHALEETLKQTHIEIMSENHKLQNLNTSLHEKFHT 250
                                  :|:.|...|..:||.|...|...|......:|...:...|..:
plant   163 ----------------------DTSKSDEVVRKVEEALALRHSSTMELMGLFENTIDTQKTKAES 205

  Fly   251 MSLKMKEYQDAHTAKETENAELKNQIDELQYDLEKIHCRNDKLENHLAEAIEKLKAYHQIYGDPN 315
            :|      |..|..|.||:|.::
plant   206 IS------QSLHAVKSTEDATIQ------------------------------------------ 222

  Fly   316 KSTNSAKTPTTTGSGGATTSVNSQLLEELQKELEEYRELANNRLQELDKLHATHRETLKEVEKLK 380
                             .:|:| .|::|..|.|.|.          :|.||..|:|..::::..
plant   223 -----------------LSSIN-DLMKEESKNLREM----------IDALHVRHKEHSEQIQAY- 258

  Fly   381 MDIRQLPESVIVETTEYKCLQSQFSVLYNESMQIKTMLDETRNQLQTSKNQ-------HLRQIEV 438
                     :...:|:    ||:...|..:..:||..|:|.|.:|.|.|.|       |:....:
plant   259 ---------ISSHSTD----QSELKHLKGQLEEIKAELEENRRKLITLKMQKDAACEGHVTSPAI 310

  Fly   439 ----MESEELIAQKKVRSEMIQMEDVLALIRKEYETLRIEFEQNMAANEQTAPINREMR------ 493
                :..|:.:.:.|:|.....::::..:.......|:...|.|::.:.|...|..|::
plant   311 ANGSLSPEKPVDKTKLRELKDSIDEIKIMAEGRLSELQASQEYNLSLSRQCQDIENELKDDQYIY 375

  Fly   494 --HLITSLQNHNGQLKGEVQRYK---------RKYKDTSTDNLKLRQELADALATLEGNKLQAAT 547
              .|.:.:.:.......|:.|||         |.:.......|.||.|..:|     .|......
plant   376 SSRLYSLINDRIHHWNAELDRYKILTEAIQAERSFVMRRDKELNLRAESLEA-----ANHKTTTV 435

  Fly   548 GAAGEEIKQENSTGVKEENSNNVSASGQTNQTNSGNDTNVAIK--EENHISAEDEADDEASGKD- 609
            |:..|.::::..:.:.|:|...:             :|..||:  |...|.:|..|......|:
plant   436 GSRIEVLEKKLQSCIIEKNGLEL-------------ETEEAIQDSERQDIKSEFIAMASTLSKEM 487

  Fly   610 --VKDGIKQEKLSSGDAAAAEKKDSPGPGNSTSSATNSVPVKNEKDSKDGVKGKDVKAVESETVR 672
              ::..:|:.|.::.||....::          :.:..|.:.|:.|.:.|::.|..|  :...::
plant   488 EMMEAQLKRWKDTAQDALYLREQ----------AQSLRVSLSNKADEQKGLEDKCAK--QMAEIK 540

  Fly   673 DLKAQLKKALNDQKEMKLLLDMYKGVSKDQRDKVQLMATEKKLRSEIEELRQ---------QLKK 728
            .|||.::|.|.::.:::.|..:......|.|...::..:::|.:::.|||:.         ::|.
plant   541 SLKALIEKLLKEKLQLQNLASICTRECNDDRGLAEIKDSQRKAQAQAEELKNVLDEHFLELRVKA 605

  Fly   729 LQESKREERKKLADEEA----LRKIKQLEEQK-YELQKQMANHKPTDNSWGSGAPGTANYTRPFV 788
            ..|::...:::||..:|    ||....|.|:: .||::.:.                       |
plant   606 AHETESACQERLATAKAEIAELRTQLDLSEREVLELKEGIK-----------------------V 647

  Fly   789 GSHEEEALLNEMEVTGQAFEDMQEQNSRLIQQLREKDDANFKLMSERIKANQLHKLLREEKTVLE 853
            ...|.||.:.|||..|||:||||.||..|:||:.|:||.|.||:||.:|....:.....||.|:|
plant   648 KEQEAEASIAEMETIGQAYEDMQTQNQHLLQQVAERDDYNIKLVSESVKTKHAYNTHLSEKQVME 712

  Fly   854 DQMATATTQIEAMHIVLRKLEEKER------------------SLQAT---VASIEKELMLRQQA 897
            .|:......:|.....:...||:.:                  ||:.|   ||..:||....:.|
plant   713 KQLHQVNASVENFKARIAHNEEQMKGCFSEAYKLIQEDRHLVISLETTKWEVADADKEFRWLKSA 777

  Fly   898 MEMHKRKAIESAQSAADLKLHLEKYHAQMKEAQQVVAEKTSSLEAEAYKTKRLQEELAQFKRKAE 962
            :...:::..:.::...|:||.|:.                     |..:.|:|:|||.:..::.|
plant   778 VSSSEKEYEQISRRTDDIKLELDD---------------------ERREKKKLEEELMELNKELE 821

  Fly   963 RMKKMEMSGTTIDEVMI---EEIREYKETLTCPSCKVKRKDAVLSKCFHVFCYDCLRTRYETRQR 1024
                 |:...:::..::   ||::..|..|.|..|..:.|:.|:.||:|:||..|::...|.|.|
plant   822 -----ELGSESVEAAIVRLQEEVKNCKNILKCGVCFDRPKEVVIVKCYHLFCQQCIQRSLEIRHR 881

  Fly  1025 KCPKCNCAFGAND 1037
            |||.|..|||.||
plant   882 KCPGCGTAFGQND 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bre1	NP_001286950.1	SMC_prok_B	<235..987	CDD:274008	159/822 (19%)
		AAA_23	<654..762	CDD:290211	26/121 (21%)
		zf-C3HC4_2	991..1029	CDD:290634	16/37 (43%)
HUB2	NP_564680.4	RING	848..886	CDD:214546	16/37 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	119	1.000	Domainoid score	I1910
eggNOG	1	0.900	-	-		E1_KOG0978
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1547
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D782448at2759
OrthoFinder	1	1.000	-	-		FOG0001777
OrthoInspector	1	1.000	-	-		otm2654
orthoMCL	1	0.900	-	-		OOG6_103285
Panther	1	1.100	-	-	LDO	PTHR23163
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1307
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870