Protein Alignment Bre1 and rnf40

DIOPT Version :10

• Sequence 1: NP_647989.2
• Gene: Bre1 / 38652
• FlyBaseID: FBgn0086694
• Length: 1044
• Species: Drosophila melanogaster
• Sequence 2: XP_068080760.1
• Gene: rnf40 / 798088
• ZFINID: ZDB-GENE-030131-6607
• Length: 1010
• Species: Danio rerio
• Alignment Length: 1144
• Identity: 478/1144 - (41%)
• Similarity: 661/1144 - (57%)
• Gaps: 236/1144 - (20%)

  Fly     1 MSKR-SADDATGSSCLVAAAAAGQPPIKKVH---------FEPHLIGPVSTLEEMDIKVLEFQNK 55
            |||: |...|.|........:...||.||:.         .||..||.||:.||||:||::|:||
Zfish     1 MSKKGSMSGAGGGKRPSGGDSPPGPPEKKLKKEEKTTTTLIEPIRIGGVSSTEEMDMKVIQFKNK 65

  Fly    56 KLAQRIEQRMRTEAELRHRIEQLEKRQTQDDAVLNVVNRYWNQLNEDIRVLLQRFDAETA----- 115
            ||.:|:|||...|.|||.:||:|||||..||..|.:|||.|.||.|:|..|||..:.:.|
Zfish    66 KLCERLEQRQALEDELREKIEKLEKRQATDDTTLLIVNRCWTQLEENIHELLQHVEPKDAPAPVQ 130

  Fly   116 ----------------------------------------------------------------- 115
                                                                             
Zfish   131 IPATPPVPADAPVPAVAPSPAPEPSAPLPAPVEGEDGLPQPSVAAEGTEDQQQPSQEKEQQQEQQ 195

  Fly   116 ---DELENRNE----------------NEVTTSFLAQLSTWDKEELDEKLANRVQVSKRAVAKIV 161
               |.:|...|                :|...:|||.|....:|||..:|.:|:|.||.|||.:|
Zfish   196 QQPDSVEKSAEAPVADEIPAPSPLPPLSESAKAFLAILDNSSEEELTLQLQDRMQFSKGAVACMV 260

  Fly   162 QVIDRLMQRNEKI-THVLKGDSLASAGSGSGAGAGGEEEQQQASGDAETTTSSAGVHALEETLKQ 225
            .:.|||....:|: |.|              ..|..|::.|:   |..||..
Zfish   261 CIFDRLHTSIDKLCTRV--------------ESAACEDDSQR---DIATTNR------------- 295

  Fly   226 THIEIMSENHKLQNLNTSLHEKFHTMSLKMKEYQDAHTAKETENAELKNQIDELQYDLEKIHCRN 290
               :::.||::|.:|.:||..|.|.|||:..|..|..|:.||:.:|::..:::||:|:||:..|.
Zfish   296 ---KLLEENNRLYDLASSLQGKHHKMSLEYNELVDKVTSSETKVSEMETAVEDLQWDIEKLRKRE 357

  Fly   291 DKLENHLAEAIEKLK-AYHQIYGDPNKSTNSAKTPTTTGSGGATTSVNSQLLEELQKELEEYREL 354
            .||..|||||:|:|. .||             .|.::.|..|...:::.|..|.|..|||:.:||
Zfish   358 QKLNKHLAEALEQLNTGYH-------------ATGSSGGLPGGQITLSIQKFESLNAELEQNQEL 409

  Fly   355 ANNRLQELDKLHATHRETLKEVEKLKMDIRQLPESVIVETTEYKCLQSQFSVLYNESMQIKTMLD 419
            ||:|:.||:||....:|.::|.||||||:|.:||.|:.||.||||||||||:|||||:.:||.||
Zfish   410 ANSRMAELEKLQQELQEAVREGEKLKMDLRNIPEEVLKETPEYKCLQSQFSLLYNESLSVKTQLD 474

  Fly   420 ETRNQLQTSKNQHLRQIEVMESEELIAQKKVRSEMIQMEDVLALIRKEYETLRIEFEQNMAANEQ 484
            |.|..|.|:||.||||||.|||:||..|||:|:|:||:||.||.:|||||.||||||||:|||||
Zfish   475 EARALLLTAKNAHLRQIEHMESDELSLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQ 539

  Fly   485 TAPINREMRHLITSLQNHNGQLKGEVQRYKRKYKDTSTDNLKLRQELADALATLEGNKLQAATGA 549
            ..||||||||||:||||||.||||:|||||||.::|..:..||:.:..:|.|.:    |:.:.|.
Zfish   540 AGPINREMRHLISSLQNHNHQLKGDVQRYKRKLRETQMEINKLKCQSGEATALI----LEESVGD 600

  Fly   550 AGEEIKQENSTGVKEENSNNVSASGQTNQTNSGNDTNVAIKEENHISAEDEADDEASGKDVKDGI 614
            .|.|:|:|                                          |.||:...::.:..:
Zfish   601 GGLEVKKE------------------------------------------EDDDQEEEEERRREL 623

  Fly   615 KQEKLSSGDAAAAEKKDSPGPGNSTSSATNSVPVKNEKDSKDGVKGKDVKAVESETVRDLKAQLK 679
            ::::....:..|..:::                  .|:: ::..:.:::|..:|:|::.|:|:||
Zfish   624 ERQRAREREREAERERE------------------RERE-RERQRSEELKRKDSDTLKMLRAELK 669

  Fly   680 KALNDQKEMKLLLDMYKGVSKDQRDKVQLMATEKKLRSEIEELRQQLKKLQESKREERKKLADEE 744
            ||...||||||||||||...|:|||||||||.|||.::|:|||||::::|:|.:::|.||||||:
Zfish   670 KAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAEKKSKAEVEELRQRVRELEEREKKESKKLADED 734

  Fly   745 ALRKIKQLEEQKYELQKQMANHKPTDNSWGSGAPGTANYTRPFVGSHEEEALLNEMEVTGQAFED 809
            |||||:..||....|||::|..|                       .||||||:||:||||||||
Zfish   735 ALRKIRVAEETIEHLQKKLAATK-----------------------QEEEALLSEMDVTGQAFED 776

  Fly   810 MQEQNSRLIQQLREKDDANFKLMSERIKANQLHKLLREEKTVLEDQMATATTQIEAMHIVLRKLE 874
            ||||||||:|||||||||||||||||||:||::|||||||..|.||:.|..||::|..:|::|||
Zfish   777 MQEQNSRLMQQLREKDDANFKLMSERIKSNQIYKLLREEKEELADQVLTFKTQVDAQLLVVQKLE 841

  Fly   875 EKERSLQATVASIEKELMLRQQAMEMHKRKAIESAQSAADLKLHLEKYHAQMKEAQQVVAEKTSS 939
            |||..||:|:|::||||.||.||:|::||||:|:||.|.|||:.||....:::|.|..|.:..::
Zfish   842 EKEGVLQSTLATLEKELALRTQALELNKRKAVEAAQLAEDLKVQLEHTQTKLREIQASVLDNRTA 906

  Fly   940 LEAEAYKTKRLQEELAQFKRKAERMKKMEMSGTTIDEVMIEEIREYKETLTCPSCKVKRKDAVLS 1004
            .|.|:...|:.||:|::.:||.|:.||:|:. |..||::.|||.:||..|.||.|..:.|:.||:
Zfish   907 RERESVNLKKAQEDLSRLRRKLEKQKKVEVY-TDADEILQEEINQYKAKLRCPCCNTRDKETVLT 970

  Fly  1005 KCFHVFCYDCLRTRYETRQRKCPKCNCAFGANDYHRLYL 1043
            ||||||||:||:|||:||||||||||.||||||:||:|:
Zfish   971 KCFHVFCYECLKTRYDTRQRKCPKCNAAFGANDFHRIYI 1009

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bre1	NP_647989.2	SMC_prok_B	<235..987	CDD:274008	347/752 (46%)
		RING-HC_dBre1-like	975..1043	CDD:438365	45/67 (67%)
rnf40	XP_068080760.1	SMC_prok_B	<297..>955	CDD:274008	350/759 (46%)
		RING_Ubox	932..1009	CDD:473075	49/77 (64%)