DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bre1 and RNF4

DIOPT Version :9

Sequence 1:	NP_001286950.1	Gene:	Bre1 / 38652	FlyBaseID:	FBgn0086694	Length:	1044	Species:	Drosophila melanogaster
Sequence 2:	NP_001171938.1	Gene:	RNF4 / 6047	HGNCID:	10067	Length:	190	Species:	Homo sapiens

Alignment Length:	191	Identity:	41/191 - (21%)
Similarity:	64/191 - (33%)	Gaps:	46/191 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   898 MEMHKRK--AIESAQ---------SAADLKLHLEKYHAQMKEAQQVVAEKTSSLEAEAYKTKR-- 949
            |...||:  ||.|.|         |..::.|..|..........::|.....|||........
Human     1 MSTRKRRGGAINSRQAQKRTREATSTPEISLEAEPIELVETAGDEIVDLTCESLEPVVVDLTHND 65

  Fly   950 ---LQEELAQFKRKAERMKKMEMSGTTI---DEVMIEEIREY-------------------KETL 989
               :.:|..:.:|.|.|:.:.......:   ||.:..:...|                   ..|:
Human    66 SVVIVDERRRPRRNARRLPQDHADSCVVSSDDEELSRDRDVYVTTHTPRNARDEGATGLRPSGTV 130

  Fly   990 TCPSCK------VKRKDAVLS-KCFHVFCYDCLRTRYETRQRKCPKCNCAFGANDYHRLYL 1043
            :||.|.      |:....::| :|.||||..|||...: ....||.|........||.:|:
Human   131 SCPICMDGYSEIVQNGRLIVSTECGHVFCSQCLRDSLK-NANTCPTCRKKINHKRYHPIYI 190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bre1	NP_001286950.1	SMC_prok_B	<235..987	CDD:274008	21/126 (17%)
		AAA_23	<654..762	CDD:290211
		zf-C3HC4_2	991..1029	CDD:290634	15/44 (34%)
RNF4	NP_001171938.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		8/27 (30%)
		Required for ubiquitination activity. /evidence=ECO:0000250	1..16		6/14 (43%)
		Mediates interaction with TRPS1. /evidence=ECO:0000250	4..61		13/56 (23%)
		SUMO interaction motif 1. /evidence=ECO:0000269\|PubMed:18408734	36..39		0/2 (0%)
		SUMO interaction motif 2. /evidence=ECO:0000269\|PubMed:18408734	46..49		1/2 (50%)
		SUMO interaction motif 3. /evidence=ECO:0000269\|PubMed:18408734	57..59		0/1 (0%)
		SUMO interaction motif 4. /evidence=ECO:0000269\|PubMed:18408734	67..70		0/2 (0%)
		RING-HC_RNF4	127..180	CDD:319447	17/53 (32%)
		RING-HC finger (C3HC4-type)	132..176	CDD:319447	15/44 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R146
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940