DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bre1 and TRIM39

DIOPT Version :9

Sequence 1:	NP_001286950.1	Gene:	Bre1 / 38652	FlyBaseID:	FBgn0086694	Length:	1044	Species:	Drosophila melanogaster
Sequence 2:	NP_067076.2	Gene:	TRIM39 / 56658	HGNCID:	10065	Length:	518	Species:	Homo sapiens

Alignment Length:	366	Identity:	76/366 - (20%)
Similarity:	146/366 - (39%)	Gaps:	87/366 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   629 KKDSPGPGNSTSSATNSVPVKNEKDSKDGVKGKDVKAVESETVRD--LKAQLKKALN-----DQK 686
            ::|.|.|....:|...|:....:..|...: .|.::||:.: :||  |..|..:||:     ||:
Human    61 ERDFPCPVCRKTSRYRSLRPNRQLGSMVEI-AKQLQAVKRK-IRDESLCPQHHEALSLFCYEDQE 123

  Fly   687 EMKLLLDMYKGVSKDQR--------DKVQLMATEKKLRSEIEELRQQLKKLQESKREERKKLADE 743
            .:.|:.    .:|...|        |..|  ..::||:..:|.|.|:|:::...|..|.||..:.
Human   124 AVCLIC----AISHTHRAHTVVPLDDATQ--EYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGEL 182

  Fly   744 EALRKIKQLEEQKYELQKQMAN-HKPTDNSWGSGAPGTANYTRPFVGSHEEEALLNEMEVTGQAF 807
            :.|     :|.::.::.::... |:..|                    .|::.||:.:|
Human   183 KRL-----VESRRQQILREFEELHRRLD--------------------EEQQVLLSRLE------ 216

  Fly   808 EDMQEQNSRLIQQLRE---------KDDANFKLMSERIKANQLHKLLREEKTVLEDQM-----AT 858
                |:...::|:|||         :|.|:.....|........::|::.|:.||..:     .:
Human   217 ----EEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKNIPRKFGGS 277

  Fly   859 ATTQIEAMHIVLRKLE------EKERSLQATVASIEKELMLRQQAMEMHK-RKAIESAQSAADLK 916
            .:|.....|..|..|.      ||.::::.|..|||.|........:... ||.::  |..||:.
Human   278 LSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILK--QLIADVT 340

  Fly   917 LHLEKYHAQMKEAQQVVAEKTSSLEAEAYKTKRLQEELAQF 957
            |..|..|..:     |::|...|::....:.:.|.:...:|
Human   341 LDPETAHPNL-----VLSEDRKSVKFVETRLRDLPDTPRRF 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bre1	NP_001286950.1	SMC_prok_B	<235..987	CDD:274008	76/366 (21%)
		AAA_23	<654..762	CDD:290211	29/122 (24%)
		zf-C3HC4_2	991..1029	CDD:290634
TRIM39	NP_067076.2	RAD18	20..>179	CDD:333230	31/125 (25%)
		RING-HC_TRIM39_C-IV	26..69	CDD:319515	3/7 (43%)
		RING-HC finger (C3HC4-type)	29..69	CDD:319515	3/7 (43%)
		AtpF	175..352	CDD:333342	42/218 (19%)
		Interaction with CDKN1A. /evidence=ECO:0000269\|PubMed:23213251	268..337		14/70 (20%)
		SPRY_PRY_TRIM39	335..513	CDD:293979	10/47 (21%)
		Interaction with CDKN1A. /evidence=ECO:0000269\|PubMed:23213251	389..518
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R146
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030