Protein Alignment Bre1 and rnf20

DIOPT Version :10

• Sequence 1: NP_647989.2
• Gene: Bre1 / 38652
• FlyBaseID: FBgn0086694
• Length: 1044
• Species: Drosophila melanogaster
• Sequence 2: NP_001243104.2
• Gene: rnf20 / 402838
• ZFINID: ZDB-GENE-130404-2
• Length: 1011
• Species: Danio rerio
• Alignment Length: 1108
• Identity: 439/1108 - (39%)
• Similarity: 636/1108 - (57%)
• Gaps: 169/1108 - (15%)

  Fly     3 KRSADDATGSSCLVAAAAAGQPPIKKVHFEPH-----------------LIGPVSTLEEMDIKVL 50
            ||.:|  .|||     ||.|.||.||...|..                 .:|..:.|||.|||.|
Zfish     5 KRPSD--AGSS-----AALGAPPEKKKGGEDGEGMSTGSGGSTAVETVIKLGGGANLEEQDIKAL 62

  Fly    51 EFQNKKLAQRIEQRMRTEAELRHRIEQLEKRQTQDDAVLNVVNRYWNQLNEDIRVLLQRFDAETA 115
            :.:|:||.:.::||...|.|||.|:|.||.||..|||.|.::||||||.:|.:|:.::..|...:
Zfish    63 QIKNRKLGEALDQRQVIEDELRERVETLETRQATDDASLLILNRYWNQFDEHVRLFIRCCDQSGS 127

  Fly   116 DELENR---------------------------NENEVTTSFLAQLSTWDKEELDEKLANRVQVS 153
            :.:|::                           .:.|..:||||.|::...||:|.:|..||:.|
Zfish   128 EPVESQPPEGRSLKPGTPEPDGDSNQERAKDRGQQGEGVSSFLATLASSTSEEIDAELQERVESS 192

  Fly   154 KRAVAKIVQVIDRLMQRNEKITHVLKGDSLASAGSGSGAGAGGEEEQQQASGDAETTTSSAGVHA 218
            .:..:::|::.:.|....:::...|:        ||...|
Zfish   193 CKQASRVVEIYENLKNMVDQLKKDLE--------SGKDGG------------------------- 224

  Fly   219 LEETLKQTHIEIMSENHKLQNLNTSLHEKFHTMSLKMKEYQDAHTAKETENAELKNQIDELQYDL 283
            |.:...:.:..:...|.:|..|...|.:|...|:.:.:....|....:...:||:..|:|||:|:
Zfish   225 LWDVAVRLNALLTGMNERLCQLTDGLQQKHSHMTSESRSLGRAANRADNRISELQGLIEELQWDM 289

  Fly   284 EKIHCRNDKLENHLAEAIEKL--KAYHQIYGDPNKSTNSAKTPTTTGSGGATTSVNSQLLEELQK 346
            |||..|.::|..||.|.:|::  |.| ::.|:             ..|...|.::|.:..||:..
Zfish   290 EKIRRRENRLNTHLVEVLERVNSKGY-KVCGE-------------ASSVCGTITINKRKFEEMNS 340

  Fly   347 ELEEYRELANNRLQELDKLHATHRETLKEVEKLKMDIRQLPESVIVETTEYKCLQSQFSVLYNES 411
            ||||.||||.|||.||.||....:...:|...:|:::....|.|..::.||:|||||||||||||
Zfish   341 ELEENRELAENRLSELQKLQQDLQTVYQENTNMKVELLSRAEEVARDSAEYRCLQSQFSVLYNES 405

  Fly   412 MQIKTMLDETRNQLQTSKNQHLRQIEVMESEELIAQKKVRSEMIQMEDVLALIRKEYETLRIEFE 476
            :.:|:.||||:.:|.|::...|||::.||::|:..|:|||:|:||:||.||.:|||||.||||||
Zfish   406 LVLKSQLDETKARLNTTRTARLRQLDHMENDEVSLQRKVRTEVIQLEDTLAQVRKEYEMLRIEFE 470

  Fly   477 QNMAANEQTAPINREMRHLITSLQNHNGQLKGEVQRYKRKYKDTSTDNLKLRQELADALATLEGN 541
            |.:|||||..||||||||||::||.||.|:||||.:||          |:||:      |..|.|
Zfish   471 QTLAANEQAGPINREMRHLISTLQTHNQQMKGEVVKYK----------LRLRE------AQQELN 519

  Fly   542 KLQAATGAAGEEIKQENSTGVKEE---------------------NSNNVSASGQTNQTNSGNDT 585
            :|:||.|.|..:.:......||||                     .|...|.:|.|.:|..|.|.
Zfish   520 QLRAAKGNAAVQSQSSTEMDVKEETVSPLTPAPTTDVTVKTEPDSGSATPSTTGITVKTEPGTDA 584

  Fly   586 NVAIKEENHISAEDEADDEASGKDVKDGIKQEKLSSGDAAAAEKKDSPGPGNSTSSATNSVPVKN 650
            ...:|||.....:|:..::...|:.::..:..:.|:|.....|::|..|   ::||.:..:||:
Zfish   585 ETVVKEEEKEKEKDKEKEKDKEKEQRERERVTRGSTGSLGVKEERDKAG---TSSSQSEDIPVE- 645

  Fly   651 EKDSKDGVKGKDVKAVESETVRDLKAQLKKALNDQKEMKLLLDMYKGVSKDQRDKVQLMATEKKL 715
                :..|.| ..|..|.|.::.::.:||||...|:|||||||||:...|:|||||||||.|||.
Zfish   646 ----RCAVIG-GPKRKEMEQLKIVRVELKKAQESQREMKLLLDMYRSAPKEQRDKVQLMAAEKKT 705

  Fly   716 RSEIEELRQQLKKLQESKREERKKLADEEALRKIKQLEEQKYELQKQMANHKPTDNSWGSGAPGT 780
            :||.|||||::::|:|.:|.|.||:|||||||||:.:|||...|.|:::
Zfish   706 KSEAEELRQRVRELEERERREGKKMADEEALRKIRSVEEQIDILNKKLS---------------- 754

  Fly   781 ANYTRPFVGSHEEEALLNEMEVTGQAFEDMQEQNSRLIQQLREKDDANFKLMSERIKANQLHKLL 845
                   :...||:|||:||:|||||||||||||.||:|||||||||||||||||||:||:||||
Zfish   755 -------LAKQEEDALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLL 812

  Fly   846 REEKTVLEDQMATATTQIEAMHIVLRKLEEKERSLQATVASIEKELMLRQQAMEMHKRKAIESAQ 910
            :|||..|.||:.|..||::|...|:||||||||.||.|:::.|:||.||.||:||:||||.:|..
Zfish   813 KEEKEELADQLLTLKTQVDAQLQVVRKLEEKERLLQGTISAAERELGLRTQALEMNKRKAQDSVL 877

  Fly   911 SAADLKLHLEKYHAQMKEAQQVVAEKTSSLEAEAYKTKRLQEELAQFKRKAERMKKMEMSGTTID 975
            .:.:::..||....:::..::.|.|.:.|.|.|::..:|.||::::.:||.|:.||...:....|
Zfish   878 LSEEVRTQLEGVQQRLRSVREEVIENSISREKESFNARRAQEDISKLRRKIEKAKKPAENIRNGD 942

  Fly   976 EVMIEEIREYKETLTCPSCKVKRKDAVLSKCFHVFCYDCLRTRYETRQRKCPKCNCAFGANDYHR 1040
            |::.|||.|||..||||.|..:.|||||:|||||||::|::|||:||||||||||.||||||:||
Zfish   943 EILNEEINEYKARLTCPCCNSRVKDAVLTKCFHVFCFECVKTRYDTRQRKCPKCNAAFGANDFHR 1007

  Fly  1041 LYL 1043
            :|:
Zfish  1008 IYI 1010

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bre1	NP_647989.2	SMC_prok_B	<235..987	CDD:274008	326/774 (42%)
		RING-HC_dBre1-like	975..1043	CDD:438365	47/67 (70%)
rnf20	NP_001243104.2	None