DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bre1 and Rnf20

DIOPT Version :9

Sequence 1:	NP_001286950.1	Gene:	Bre1 / 38652	FlyBaseID:	FBgn0086694	Length:	1044	Species:	Drosophila melanogaster
Sequence 2:	NP_001101399.2	Gene:	Rnf20 / 313216	RGDID:	1311936	Length:	973	Species:	Rattus norvegicus

Alignment Length:	1073	Identity:	462/1073 - (43%)
Similarity:	653/1073 - (60%)	Gaps:	158/1073 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 AAGQ-----PPIKKVHFEPH-------LIGPVSTLEEMDIKVLEFQNKKLAQRIEQRMRTEAELR 72
            |||:     ||.||...|..       .:|.||:.||:||:.|:.:|:|||:.::||...|.|||
  Rat     9 AAGEPGTSVPPEKKTAVEDSGTTVETIKLGGVSSTEELDIRTLQSKNRKLAEMLDQRQAIEDELR 73

  Fly    73 HRIEQLEKRQTQDDAVLNVVNRYWNQLNEDIRVLLQRFD-------------------------- 111
            ..||:||:||..|||.|.:|||||:|.:|:||::|:|:|
  Rat    74 EHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKRYDLDQGLGDLLTERKALVVPEPEPDSDS 138

  Fly   112 -AETADELENRNENEVTTSFLAQLSTWDKEELDEKLANRVQVSKRAVAKIVQVIDRLMQRNEKIT 175
             .|..|:.|.....|...||||.|::...||::.:|..||:.|:|||::||.|.|:|.::.:.::
  Rat   139 NQERKDDRERGEGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVDLLS 203

  Fly   176 HVL-KGDSLASAGSGSGAGAGGEEEQQQASGDAETTTSSAGVHALEETLKQTHIEIMSENHKLQN 239
            ..| .||:|                                  .:||.:::.:..:..||.:||.
  Rat   204 RKLNSGDNL----------------------------------IMEEAVQELNSFLAQENVRLQE 234

  Fly   240 LNTSLHEKFHTMSLKMKEYQDAHTAKETENAELKNQIDELQYDLEKIHCRNDKLENHLAEAIEKL 304
            |...|.||.||||.:..:.|......|:..:.|::.||:||:|::||..|..:|..||||.:|::
  Rat   235 LTDLLQEKHHTMSQEFCKLQGKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERV 299

  Fly   305 --KAYHQIYGDPNKSTNSAKTPTTTGSG--GATTSVNSQLLEELQKELEEYRELANNRLQELDKL 365
              |.| ::||              .||.  |.|.::|::..||:..||||.:|||.||..||:||
  Rat   300 NSKGY-KVYG--------------AGSSLYGGTITINARKFEEMNAELEENKELAQNRHCELEKL 349

  Fly   366 HATHRETLKEVEKLKMDIRQLPESVIVETTEYKCLQSQFSVLYNESMQIKTMLDETRNQLQTSKN 430
            .....|...:.||||:::|...|.|:.||.||:|:|||||||||||:|:|..|||.|..|..::.
  Rat   350 RQDFEEVTTQNEKLKVELRSAVEEVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRG 414

  Fly   431 QHLRQIEVMESEELIAQKKVRSEMIQMEDVLALIRKEYETLRIEFEQNMAANEQTAPINREMRHL 495
            .|.||:|::|.:|:...||:|:|:||:||.||.:|||||.|||||||.:|||||..|||||||||
  Rat   415 THQRQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHL 479

  Fly   496 ITSLQNHNGQLKGEVQRYKRKYKDTSTDNLKLRQELADALATLEGNKLQAATGAAGE---EIKQE 557
            |:||||||.||||||.|||||.::..:|..|.|.....||.     :.|::|..|.:   |:||:
  Rat   480 ISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALL-----QSQSSTEDAKDEPTELKQD 539

  Fly   558 NSTGVKEENSNNVSA--SGQTNQTNSGNDTNVAIKEENHISAEDEADDEASGKDVKDGIKQEKLS 620
            :     |:.:.:.||  :.|.::..|..|.....:|......|.|.:.|   |:.:...:::||.
  Rat   540 S-----EDLATHSSALKASQEDEVKSKRDEEERERERREKERERERERE---KEKEREREKQKLK 596

  Fly   621 SGDAAAAEKKDSPGPGNSTSSATNSVPVKNEKDSKDGVKGKDVKAVESETVRDLKAQLKKALNDQ 685
            ..:    :::|               |||:    ||..|..|.:..|:|.::.||.:||||...|
  Rat   597 ESE----KERD---------------PVKD----KDKGKHDDGRKKEAEIIKQLKTELKKAQESQ 638

  Fly   686 KEMKLLLDMYKGVSKDQRDKVQLMATEKKLRSEIEELRQQLKKLQESKREERKKLADEEALRKIK 750
            ||||||||||:...|:|||||||||.|||.::|:|:|||:||.|::.:::|.||:|||:|||||:
  Rat   639 KEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIR 703

  Fly   751 QLEEQKYELQKQMANHKPTDNSWGSGAPGTANYTRPFVGSHEEEALLNEMEVTGQAFEDMQEQNS 815
            .:|||...|||::|                       |...||||||:||:|||||||||||||.
  Rat   704 AVEEQIEYLQKKLA-----------------------VAKQEEEALLSEMDVTGQAFEDMQEQNI 745

  Fly   816 RLIQQLREKDDANFKLMSERIKANQLHKLLREEKTVLEDQMATATTQIEAMHIVLRKLEEKERSL 880
            ||:|||||||||||||||||||:||:||||:|||..|.||:.|..||::|...|:|||||||..|
  Rat   746 RLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLL 810

  Fly   881 QATVASIEKELMLRQQAMEMHKRKAIESAQSAADLKLHLEKYHAQMKEAQQVVAEKTSSLEAEAY 945
            |:.:.:.||||.||.||:||:||||:|:||.|.|||..||....::.:.|..:.|.:.:.|.:.:
  Rat   811 QSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDLF 875

  Fly   946 KTKRLQEELAQFKRKAERMKKMEMSGTTIDEVMIEEIREYKETLTCPSCKVKRKDAVLSKCFHVF 1010
            ..||.||::::.:||.|..||.: :....||:::|||::||..||||.|.:::|||||:||||||
  Rat   876 NFKRAQEDISRLRRKLETTKKPD-NVPKCDEILMEEIKDYKARLTCPCCNMRKKDAVLTKCFHVF 939

  Fly  1011 CYDCLRTRYETRQRKCPKCNCAFGANDYHRLYL 1043
            |::|::|||:||||||||||.||||||:||:|:
  Rat   940 CFECVKTRYDTRQRKCPKCNAAFGANDFHRIYI 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bre1	NP_001286950.1	SMC_prok_B	<235..987	CDD:274008	342/760 (45%)
		AAA_23	<654..762	CDD:290211	60/107 (56%)
		zf-C3HC4_2	991..1029	CDD:290634	26/37 (70%)
Rnf20	NP_001101399.2	RING	919..962	CDD:238093	30/42 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349388
Domainoid	1	1.000	710	1.000	Domainoid score	I111
eggNOG	1	0.900	-	-		E1_KOG0978
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	810	1.000	Inparanoid score	I458
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D139233at33208
OrthoFinder	1	1.000	-	-		FOG0001777
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103285
Panther	1	1.100	-	-	O	PTHR23163
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1307
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760