DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bre1 and Rnf40

DIOPT Version :9

Sequence 1:	NP_001286950.1	Gene:	Bre1 / 38652	FlyBaseID:	FBgn0086694	Length:	1044	Species:	Drosophila melanogaster
Sequence 2:	XP_006230281.1	Gene:	Rnf40 / 266712	RGDID:	628638	Length:	1007	Species:	Rattus norvegicus

Alignment Length:	1091	Identity:	476/1091 - (43%)
Similarity:	665/1091 - (60%)	Gaps:	139/1091 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SKRSADDATGSSCLVAAAAAGQPPIKKVH---------FEPHLIGPVSTLEEMDIKVLEFQNKKL 57
            :||:|.|. ||.          ||.||::         .||..:|.:|:.||||.|||:|:||||
  Rat     6 NKRAAGDG-GSG----------PPEKKLNREEKTTTTLIEPIRLGGISSTEEMDSKVLQFKNKKL 59

  Fly    58 AQRIEQRMRTEAELRHRIEQLEKRQTQDDAVLNVVNRYWNQLNEDIRVLLQ-------------- 108
            |:|:|||...|.|||.|||:|||||..|||.|.:|||||.||:|.:..|||
  Rat    60 AERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLQCYENQRELSSSGTE 124

  Fly   109 --------------RFDAETADELE------NRNENEVTTSFLAQLSTWDKEELDEKLANRVQVS 153
                          |.|..|:|..|      ....:|...:|:..|.....||::.:|..|::.|
  Rat   125 VPGCQEGLTRDVIPRTDPGTSDLREPLPMQFRAPLSEPALAFVVALGASSCEEVELQLQGRMEFS 189

  Fly   154 KRAVAKIVQVIDRLMQRNEKITHVLKGDSLASAGSGSGAGAGGEEEQQQASGDAETTTSSAGVHA 218
            |.||:::|:..|||.::.|::.     ..:.|.||.             .|||:|         |
  Rat   190 KAAVSRVVEASDRLQRQVEELC-----QRVYSRGSA-------------FSGDSE---------A 227

  Fly   219 LEETLKQTHIEIMSENHKLQNLNTSLHEKFHTMSLKMKEYQDAHTAKETENAELKNQIDELQYDL 283
            ..|..:....|:..||.:||:|.|.|.||.|.:||:..|.||..|:.||:..|::..:::||:|:
  Rat   228 PGEVARARTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSTETKVLEMETTVEDLQWDI 292

  Fly   284 EKIHCRNDKLENHLAEAIEKLKAYHQIYGDPNKSTNSAKTPTTTGSGGATTSVNSQLLEELQKEL 348
            ||:..|..||..|||||:|:|.:.:.:.|            ::||..|...:::.|..|.|..||
  Rat   293 EKLRKREQKLNKHLAEALEQLNSGYYVSG------------SSTGFQGGQITLSMQKFEMLNAEL 345

  Fly   349 EEYRELANNRLQELDKLHATHRETLKEVEKLKMDIRQLPESVIVETTEYKCLQSQFSVLYNESMQ 413
            ||.:||||:|:.||:||.|..:..::..|:||:.:|.|||.|:.||.||:.||:|||:|||||:|
  Rat   346 EENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQ 410

  Fly   414 IKTMLDETRNQLQTSKNQHLRQIEVMESEELIAQKKVRSEMIQMEDVLALIRKEYETLRIEFEQN 478
            :||.|||.|..|..|||.|||.||.|||:||..|||:|:|:||:||.||.:|||||.||||||||
  Rat   411 VKTQLDEARGLLLASKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQN 475

  Fly   479 MAANEQTAPINREMRHLITSLQNHNGQLKGEVQRYKRKYKDTSTDNLKLRQELADA------LAT 537
            :|||||..||||||||||:||||||.||||:.||||||.::...:..|||.:.:.:      |:.
  Rat   476 LAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSSHCGPNLSH 540

  Fly   538 LEGNKLQAATGAAGEEIKQENSTGVKEENSNNVSASGQTNQTNSGNDTNVAIKEENHISAEDEAD 602
            .:.:.|.|.  |.|:|.......|..:........:|.|:..:|       :|:|..:|:||:|.
  Rat   541 PDDSGLNAL--APGKEDSGPGPGGTPDSKKELALVAGATSVASS-------VKKEELVSSEDDAQ 596

  Fly   603 DEASGKDVKDGIKQEKLSSGDAAAAEKKDSPGPGNSTSSATNSVPVKNEKDSKDGVKGKDVKAVE 667
            ..|.|   ..|:.............|.::..||......|.:::    .:..::..|.::.:..|
  Rat   597 ALAPG---TQGLPSRGREPEARPKRELREREGPSLGPPPAASTL----SRADREKAKAEEARRKE 654

  Fly   668 SETVRDLKAQLKKALNDQKEMKLLLDMYKGVSKDQRDKVQLMATEKKLRSEIEELRQQLKKLQES 732
            ||.::.|:|:||||...||||||||||||...|:|||||||||.|:|.::|::|||.:::.|:|.
  Rat   655 SELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRDLEER 719

  Fly   733 KREERKKLADEEALRKIKQLEEQKYELQKQMANHKPTDNSWGSGAPGTANYTRPFVGSHEEEALL 797
            .|.|.||:|||:|||:|:|.|||...||:::...|                       .||||||
  Rat   720 DRRESKKIADEDALRRIRQAEEQIEHLQRKLGATK-----------------------QEEEALL 761

  Fly   798 NEMEVTGQAFEDMQEQNSRLIQQLREKDDANFKLMSERIKANQLHKLLREEKTVLEDQMATATTQ 862
            :||:|||||||||||||.||:||||||||||||||||||||||:||||||||..|.:|:....:|
  Rat   762 SEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQ 826

  Fly   863 IEAMHIVLRKLEEKERSLQATVASIEKELMLRQQAMEMHKRKAIESAQSAADLKLHLEKYHAQMK 927
            ::|..:.::|||||||:||.::..:||||.||.||:|::||||:|:||.|.|||:.||....:::
  Rat   827 VDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLR 891

  Fly   928 EAQQVVAEKTSSLEAEAYKTKRLQEELAQFKRKAERMKKMEMSGTTIDEVMIEEIREYKETLTCP 992
            |.|..:||..::.|.|::..||.||::::.:||.|:.:|:|:.... ||::.|||:|||..||||
  Rat   892 EIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADA-DEILQEEIKEYKARLTCP 955

  Fly   993 SCKVKRKDAVLSKCFHVFCYDCLRTRYETRQRKCPKCNCAFGANDYHRLYL 1043
            .|..::|||||:|||||||::|:|.|||.|||||||||.||||:|:||:|:
  Rat   956 CCNTRKKDAVLTKCFHVFCFECVRGRYEARQRKCPKCNAAFGAHDFHRVYI 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bre1	NP_001286950.1	SMC_prok_B	<235..987	CDD:274008	345/757 (46%)
		AAA_23	<654..762	CDD:290211	57/107 (53%)
		zf-C3HC4_2	991..1029	CDD:290634	26/37 (70%)
Rnf40	XP_006230281.1	SMC_prok_B	225..926	CDD:274008	341/760 (45%)
		BRE1	760..854	CDD:285810	63/93 (68%)
		RING	953..996	CDD:238093	30/42 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349387
Domainoid	1	1.000	710	1.000	Domainoid score	I111
eggNOG	1	0.900	-	-		E1_KOG0978
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8856
Inparanoid	1	1.050	810	1.000	Inparanoid score	I458
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D139233at33208
OrthoFinder	1	1.000	-	-		FOG0001777
OrthoInspector	1	1.000	-	-		oto97286
orthoMCL	1	0.900	-	-		OOG6_103285
Panther	1	1.100	-	-	LDO	PTHR23163
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1307
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.760