DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bre1 and brl2

DIOPT Version :9

Sequence 1:	NP_001286950.1	Gene:	Bre1 / 38652	FlyBaseID:	FBgn0086694	Length:	1044	Species:	Drosophila melanogaster
Sequence 2:	NP_587845.1	Gene:	brl2 / 2539307	PomBaseID:	SPCC970.10c	Length:	680	Species:	Schizosaccharomyces pombe

Alignment Length:	780	Identity:	162/780 - (20%)
Similarity:	314/780 - (40%)	Gaps:	214/780 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 VNSQLLEELQKELEEYRELANNRLQELDKLHATHRETLKEVEKLKMDIRQLPESVIVETTEYKCL 400
            |.|...:||:.::|..:.||..:|:.|..|.:...|.|::.            ||:.:..|.|..
pombe    43 VRSIQFDELESKIEGLQNLAEEKLKVLATLVSWWPEILQQF------------SVVFQGNELKDF 95

  Fly   401 QSQ--FSVL--------YNESMQIKTMLDETRNQLQTSKNQHLRQIEVMESEELIAQKKVRSEMI 455
            :|:  ||:|        :|:::                ||...:.:.:::        |:.|.:.
pombe    96 ESEGVFSILEKFPELSYFNDAV----------------KNNKTKALSIIQ--------KLLSTVD 136

  Fly   456 QMEDVLALIRKEYETLRIEFEQNMAANEQTAPINREMRHLITSLQNHNGQLKGEVQRYKRKYKDT 520
            ...:  ::.|..:..|.|:   :.|..|:...||.::..::..|.....||...:     |..|.
pombe   137 SSTN--SVSRDPFSVLSID---DSALTEKLNTINLDIDKILDELDTTRSQLHSII-----KLPDR 191

  Fly   521 STDNLKLRQELADALATLEGNKLQAATGAAGEEIKQENSTGVKEENSNNVSASGQTNQTN-SGND 584
            |:.            .||:         ...|.::.: ||.||||.:  .|:.|:..:.. |..:
pombe   192 SSS------------FTLQ---------CINESVRPQ-STKVKEEAT--TSSKGKDEEKKVSTVE 232

  Fly   585 TNVAIKEENHISAEDEADDEASGKDVKDGIKQEKLSSGDAAAAEKKDSPGPGNSTSSATNSVPVK 649
            ....:::.:.:..:.....|:..:.:|  |....::..|....|::          :|.|:|...
pombe   233 QRTQLQQLSRLQDQQNGLMESRSQSLK--ILDSNVNEMDKLIMERE----------NALNNVETT 285

  Fly   650 NEKDSKDGVKGKDVKAVESETVRDLK-------------AQLKKALN---DQKEMKLLLDMYKGV 698
            |.|.....:..|:..::.||.:|.|:             :|..|..|   :.....|:.|:...:
pombe   286 NLKKYSSFLALKEAVSMTSEQLRVLEHLLSECSHEINVLSQQSKNFNGVFESSYQPLINDLDHQI 350

  Fly   699 SKDQRDKVQL--------MATEKKLRSEIEELRQQLKKLQESKREE-----------RKKLADEE 744
            |..|.|:.::        ::.||||     |.::|.:|:.:.|.:|           :|.:|..|
pombe   351 SVMQNDEKRINNAKTELSLSLEKKL-----EAKKQKEKVYKDKLDELANLETMVLEKKKAVATRE 410

  Fly   745 ALRKIKQLEEQKYELQKQMANH-----KPTDNSWGSGAPGTANYTRPFVGSHEEEALLNEMEVTG 804
            |..||:.::....||||.::.:     ..|:.::......|...:.    ||.:| |:.:..|.
pombe   411 AANKIRLVDLNDLELQKDLSTYLSKELASTEKAFRLVKQQTVKSSH----SHYQE-LITKFSVE- 469

  Fly   805 QAFEDMQEQNSRLIQQLREKDDANFKLMSERI-KANQ-LHKLLREEKTVL------EDQMA---- 857
               ::..||...|..:..:...|..||:.::. |.|: :.|:|..:.|.:      |||:|
pombe   470 ---KEKAEQKYFLTMKSTDSLHAEVKLLRQKYQKTNEIISKMLNSQDTAVHRIIEFEDQLARLSS 531

  Fly   858 --------TATTQIEAMHIVLRKLEEKERSLQATVASIEKELMLRQQAMEMHKRKAIESAQSAAD 914
                    :.|.|:            |:.|.::|:.::|:::...||.|
pombe   532 VRNNSIKQSTTFQV------------KKSSQKSTIQNLEEKVSYLQQFM---------------- 568

  Fly   915 LKLHLEKYHAQMKEAQQVVAEKTSSLEAEAYKTKRLQEELAQFKRKAERMKKMEMSGTTIDEVMI 979
                 :|.:|.:.:.:...::.:||::.    ..:..||..:.|||   :|...:|.:.
pombe   569 -----DKNNATLTDLEFQCSDLSSSIDI----LSKQDEEHEKEKRK---LKDTGVSTSA------ 615

  Fly   980 EEIREYKETLTCPSCKVKR-KDAVLSKCFHVFCYDCLRTRYETRQRKCPKCNCAFGANDYHRLYL 1043
            ||::.::....|..|..:| ||.::|.|.|.|||.|::.|.|||||:||.|...|||:|...::|
pombe   616 EELKTFRAMCKCSVCNFERWKDRIISLCGHGFCYQCIQKRIETRQRRCPICGRGFGASDVIPIHL 680

Fly 1044 1043
pombe 681 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bre1	NP_001286950.1	SMC_prok_B	<235..987	CDD:274008	136/721 (19%)
		AAA_23	<654..762	CDD:290211	31/142 (22%)
		zf-C3HC4_2	991..1029	CDD:290634	20/38 (53%)
brl2	NP_587845.1	BRE1	433..525	CDD:285810	19/100 (19%)
brl2	NP_587845.1	RING	627..666	CDD:214546	20/38 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	52	1.000	Domainoid score	I3318
eggNOG	1	0.900	-	-		E1_KOG0978
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I1738
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001777
OrthoInspector	1	1.000	-	-		otm47272
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23163
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R146
SonicParanoid	1	1.000	-	-		X1307
TreeFam	0	0.000	Not matched by this tool.
	9	9.080