Protein Alignment Bre1 and brl1

DIOPT Version :9

• Sequence 1: NP_001286950.1
• Gene: Bre1 / 38652
• FlyBaseID: FBgn0086694
• Length: 1044
• Species: Drosophila melanogaster
• Sequence 2: NP_588497.1
• Gene: brl1 / 2539102
• PomBaseID: SPCC1919.15
• Length: 692
• Species: Schizosaccharomyces pombe
• Alignment Length: 886
• Identity: 176/886 - (19%)
• Similarity: 311/886 - (35%)
• Gaps: 265/886 - (29%)

  Fly   216 VHALEETLK-----QTHIEIMS---------ENHKLQNLNTSLHEKFHTMSLKMKEYQDAHTAKE 266
            :|:.:||.:     :..:|:..         |...|..|...|:|.:.::.||:    |.:.|..
pombe    14 IHSEKETRRLDLGEEDDLELFQKEAAWRRSREYEHLTVLEKKLYEYWESLVLKL----DHYVAAA 74

  Fly   267 TENAELKNQIDELQYDLEKIHCRNDKLEN---HLAE---------AIEKLKAYHQIYGDPN---- 315
            .||.|  ...:||:.....::..:|.|:.   .|||         .:.|..:|.|.: :|.
pombe    75 LENHE--QSFEELEKITASLYQPDDNLQTLDLSLAEFSLIKDAQNYLNKYASYFQAH-EPTLQKL 136

  Fly   316 --------KSTNSAKTPTTTGSGGATTSVN---SQL-LEELQKELEEYRELANN------RLQEL 362
                    |.|.:............|:.:|   ||| |..|:::|..:||..|:      |:|:.
pombe   137 AKFGSFKLKETPNVHEWIDQRQVHFTSMINYRTSQLKLALLKRKLSFFREALNSAELEWKRVQQD 201

  Fly   363 DKLHATHRETLKEVEKLKMDIRQLPESVIVETTEYKCLQSQFSVLYNESMQIKTMLDETRNQLQT 427
            ....|:.|    .:|.:..||.......|:|..| .||..      |::      :.:.:|..|:
pombe   202 QLTSASER----SIENIADDIPASEPKAILENGE-GCLND------NDN------ISKLKNNFQS 249

  Fly   428 SKNQHLRQIEVMESEELIAQKKVRSEMIQMEDVLALI--RKEYETLRIEFEQNMAANEQ-TAPIN 489
            ..:  |.|..:....:.::||..|:..:.: |::.:.  |...|...:|.:..:::||: ...||
pombe   250 QAD--LMQANINSKLDELSQKSTRAAQLYV-DIMGITDERVSREPHYLELKGVLSSNEEKIESIN 311

  Fly   490 REMRHLITSLQNHNGQLKGEVQRYKRKYKDTSTDNLKLRQELADALATLEGNKLQAATGAAGEEI 554
            |::..|...:|....      ||.||: ||.....|...:|....:.|||.:..|         |
pombe   312 RDLSSLFEDIQFFIS------QRTKRQ-KDIIDLKLACVKEKQQLIKTLESSLTQ---------I 360

  Fly   555 KQENSTGVKEEN---SNNVSASGQTNQTNSGNDTNVAIKE--ENHISAEDEADDEASGKDVKDGI 614
            :.|..:.|.::.   :||:.........::.::..|||.|  .|.:...|..:...:|:  .:.:
pombe   361 RNERDSLVAKQQMQYTNNLFFDDMMLLLSNLSNARVAILEGYSNRLCIWDRIERSKTGE--MNNV 423

  Fly   615 KQEKLSSGDAAAAEKKDSPGPGNSTSSATNSVPVKNEKDSKDGVKGKDVKAVESETVRDLKAQLK 679
            ..||.....::|.||.                 :||.            ..:|:|
pombe   424 LDEKEEISASSALEKL-----------------IKNN------------SCLEAE---------- 449

  Fly   680 KALNDQKEMKLLLDMYKGVSKDQRDKVQLMATEKKLRSEIEELRQQLKKLQESKREERKKLADEE 744
                       |..||....:.|                    .:.|||.:|.:.:|:|.|
pombe   450 -----------LPSMYAAFDQSQ--------------------SRLLKKYEELETKEKKAL---- 479

  Fly   745 ALRKIKQLEEQKYELQKQMANHKPTDNSWGSGAPGTANYTRPFVGSHEEEALLNEMEVTGQAFED 809
                     |..||                 .|..|..|
pombe   480 ---------EMHYE-----------------KARATQKY-------------------------- 492

  Fly   810 MQEQNSRLIQQLREKDDANFKLMSERIKANQLHKLLREEKTVLEDQMATATTQIEAMHIVLRKLE 874
                               |..|    ||..:  |:.|:||:   ::|.     ...|..:.||:
pombe   493 -------------------FAAM----KARDI--LMTEKKTL---KLAE-----NKEHDYIGKLQ 524

  Fly   875 EKERSLQATVASIEKELMLRQQAMEMHKRKAIESAQSAADLKLHLEKYHAQMKEAQQVVAEKTSS 939
            |:|.:|....:|::.||.:.:|..|::.:.::|.......|::...|...::::..:.|.:....
pombe   525 EREHALTKYESSLKAELEVYKQIKEIYGKHSVEVLTEDKHLQVKQTKLTQKLEDLIESVQKSGEK 589

  Fly   940 LEAEAYKTKRLQEELAQFKRKAERMKKMEMSGTTIDEVM-IEEIREYKETLTCPSCKVKR-KDAV 1002
            |.....|...||||......||...||   ....|::.. .:|.:.||..|.|..|.... |..:
pombe   590 LMIMHQKLFHLQEEHTILSIKASYNKK---ESHLINQAYETQEAQVYKGMLKCSVCNFSNWKSKL 651

  Fly  1003 LSKCFHVFCYDCLRTRYETRQRKCPKCNCAFGANDYHRLYL 1043
            :..|.|.||.:|:...||.:...||:|...|..:|...::|
pombe   652 IPNCGHAFCSNCMEPFYEHKTSTCPQCETPFSVSDILTIHL 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bre1	NP_001286950.1	SMC_prok_B	<235..987	CDD:274008	153/794 (19%)
		AAA_23	<654..762	CDD:290211	16/107 (15%)
		zf-C3HC4_2	991..1029	CDD:290634	12/38 (32%)
brl1	NP_588497.1	MT	227..>315	CDD:289543	21/103 (20%)
		BRE1	446..540	CDD:285810	35/223 (16%)
		RING	638..682	CDD:238093	13/43 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0978
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001777
OrthoInspector	1	1.000	-	-		otm47272
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23163
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R146
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.940