DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bre1 and Rnf4

DIOPT Version :9

Sequence 1:	NP_001286950.1	Gene:	Bre1 / 38652	FlyBaseID:	FBgn0086694	Length:	1044	Species:	Drosophila melanogaster
Sequence 2:	NP_001291198.1	Gene:	Rnf4 / 19822	MGIID:	1201691	Length:	194	Species:	Mus musculus

Alignment Length:	178	Identity:	36/178 - (20%)
Similarity:	60/178 - (33%)	Gaps:	41/178 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   903 RKAIESAQSAADLKLHLEKYHAQMKEAQQVVAEKTSSLEAEAYKTKR-----LQEELAQFKRKAE 962
            :|......|..::.|..|..........::|.....|||........     :.||..:.:|...
Mouse    21 QKRTRETTSTPEVSLETEPIELVETVGDEIVDLTCESLEPVVVDLTHNDSVVIVEERRRPRRNGR 85

  Fly   963 RMKKMEMSGTTI--DEVMIEEIREYKE-----------------------TLTCPSCK------V 996
            |:::.......:  |:   ||:...|:                       |::||.|.      |
Mouse    86 RLRQDHADSCVVSSDD---EELSRDKDVYVTTHTPRSTKDDGATGPRPSGTVSCPICMDGYSEIV 147

  Fly   997 KRKDAVLS-KCFHVFCYDCLRTRYETRQRKCPKCNCAFGANDYHRLYL 1043
            :....::| :|.||||..|||...: ....||.|........||.:|:
Mouse   148 QNGRLIVSTECGHVFCSQCLRDSLK-NANTCPTCRKKINHKRYHPIYI 194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bre1	NP_001286950.1	SMC_prok_B	<235..987	CDD:274008	15/90 (17%)
		AAA_23	<654..762	CDD:290211
		zf-C3HC4_2	991..1029	CDD:290634	15/44 (34%)
Rnf4	NP_001291198.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39		3/17 (18%)
		Required for ubiquitination activity	1..20
		Mediates interaction with TRPS1. /evidence=ECO:0000269\|PubMed:12885770	6..65		8/43 (19%)
		SUMO interaction motif 1, mediates the binding to polysumoylated substrates. /evidence=ECO:0000250\|UniProtKB:P78317	40..43		0/2 (0%)
		SUMO interaction motif 2, mediates the binding to polysumoylated substrates. /evidence=ECO:0000250\|UniProtKB:P78317	50..53		1/2 (50%)
		SUMO interaction motif 3, mediates the binding to polysumoylated substrates. /evidence=ECO:0000250\|UniProtKB:P78317	61..63		0/1 (0%)
		SUMO interaction motif 4, mediates the binding to polysumoylated substrates. /evidence=ECO:0000250\|UniProtKB:P78317	71..74		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..130		0/19 (0%)
		zf-RING_2	135..181	CDD:290367	15/46 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R146
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940