Protein Alignment Bre1 and rfp-1

DIOPT Version :9

• Sequence 1: NP_001286950.1
• Gene: Bre1 / 38652
• FlyBaseID: FBgn0086694
• Length: 1044
• Species: Drosophila melanogaster
• Sequence 2: NP_001022700.1
• Gene: rfp-1 / 176180
• WormBaseID: WBGene00007008
• Length: 837
• Species: Caenorhabditis elegans
• Alignment Length: 1095
• Identity: 252/1095 - (23%)
• Similarity: 443/1095 - (40%)
• Gaps: 310/1095 - (28%)

  Fly     1 MSKRSADDATGSSCLVAAAAAGQPPIKKVHFEPHLIGPVSTLEEMDIKVLEFQNKKLAQRIEQRM 65
            |.|||.:...|.:...:.:..||...:|:.|||..:..||.:.::..:.:.:|..||.|::..:.
 Worm     1 MMKRSNEGIGGENYASSPSDDGQQKRRKIQFEPVRMPAVSNVNDIRARAVVYQTSKLKQQLLYKN 65

  Fly    66 RTEAELRHRIEQLEKRQTQDDA-VLNVVNRYWNQLNEDIRVLL---------QRFDAETA----D 116
            :..|||....|:.::||..|:: .|.|.|.:     .||...:         :....:||    |
 Worm    66 KRIAELEKENERSKRRQQTDESNFLKVYNMF-----SDIEKYICTQTKNEFGEYIGGDTAPTGID 125

  Fly   117 ELENRNENEVTTSFLAQLSTWDK--EELDEKLAN-----------RVQVSKRAVAKIVQVIDRLM 168
            .|...||            |::|  ::..:.|.|           |...|...:.|:..:||
 Worm   126 VLGMTNE------------TYNKFFDQAKQNLRNAFVSYAKARHDRAHESTIFIDKLKTLID--- 175

  Fly   169 QRNEKITHVLKGDSLASAGSGSGAGAGGEEEQQQASGDAETTTSSAGVHALEETLKQTHIEIMSE 233
                                                   ..|.:..|||. |.|.|...:.|  :
 Worm   176 ---------------------------------------SPTFNPNGVHK-ELTAKAASLAI--Q 198

  Fly   234 NHKLQNLNTSLHEKFHTMSLKMKEYQDAHTAKETENAELKNQIDELQYDLEKIHCR-NDKLENHL 297
            |.|||:..|.:....:.:..|.:...|..:.:|....||::|:::.:::.:| |.| .:|.|..|
 Worm   199 NEKLQSEVTKVQSDCYNLERKKRILTDKLSVQENRVQELEHQLEDARFETDK-HMRLANKFEYKL 262

  Fly   298 AEAIEKLKAYHQIYGDPNKSTNSAKTPTTTGSGGAT-----------TSVNSQLLEELQKELEEY 351
            |..:          .:.....|...||:::|:..||           :...::.:|.|:.|.:|.
 Worm   263 ATLV----------SEGQSGGNGGATPSSSGTTNATEKKISAPDIPPSETAAKEIENLRLERDEQ 317

  Fly   352 RELANNRLQELDKLHATHRETLKEVEKLKMDIRQ-LPESVIVETTEYKCLQSQFSVLYNESMQIK 415
            ..:|:.|||:|::::...:...:|..||:::.:. .....||.:.|||.|:..:|:...|..::.
 Worm   318 ESIASRRLQDLEEMNKKVQTLTQENSKLRLETQTFFSVDSIVNSEEYKNLKKYYSLAIKEYERVS 382

  Fly   416 TMLDETRNQLQTSKNQHLRQIEVMESE------ELIAQKKVRSEMIQMEDVLALIRKEYETLRIE 474
            ..|::...:....::....:..:|..|      |:..|..:.:...::.....::|.|:||::.|
 Worm   383 KDLEDITTERDAFRSAKEARAMLMSEEHQKTLKEIQCQSDIHNSFYKVSHDSEVLRCEFETVKEE 447

  Fly   475 FEQNMAANEQTAPINREMRHLITSLQNHNGQLKGEVQRYKRKYKDTSTDNLKLRQELADALATLE 539
            :.:.:..:|..     ||:..:.:|::.|..||.|..|.:.|.|.:..|...|:.||
 Worm   448 YNKTVKQSEWD-----EMKATLNTLRSMNRSLKSEKIRLREKDKQSQKDINTLKSEL-------- 499

  Fly   540 GNKLQAATGAAGEEIKQENSTGVKEENSNNVSASGQTNQTNSGNDTNVAIKEENHISAEDEADDE 604
                                |.:|                                    ||.|:
 Worm   500 --------------------TSLK------------------------------------EAQDK 508

  Fly   605 ASGKDVKDGIKQEKLSSGDAAAAEKKDSPGPGNSTSSATNSVPVKNEKDSKDGVKGKDVKAVESE 669
            .....::|                             .:|:.|             :||..:..|
 Worm   509 CLLVPLED-----------------------------VSNAPP-------------EDVNKIRQE 531

  Fly   670 TVRDLKAQLKKALNDQKEMKLLLDMYKGVSKDQRDKVQLMATEKKLRSEIEELRQQLKKLQ-ESK 733
                                     |:.:.|:.:   :|.|.||      :|.::|::.|| |..
 Worm   532 -------------------------YESLCKEVK---RLGAMEK------QEKQKQVENLQKEVN 562

  Fly   734 REERKKLADEEALRKIKQLEEQKYELQKQMANHKPTDNSWGSGAPGTANYTRPFVGSHEEEALLN 798
            |:...||::.|.|||..::.                                    :::||.:.:
 Worm   563 RQIADKLSELETLRKTNEML------------------------------------TNDEECISD 591

  Fly   799 EMEVTGQAFEDMQEQNSRLIQQLREKDDANFKLMSERIKANQLHKLLREEKTVLEDQMATATTQI 863
            |:|..|.|.|:.||:|::|..:.||::|.|.|:|::|:..||....|||:.:.||.: |....||
 Worm   592 ELEAIGTAVEEEQERNAQLYIEKREQEDRNLKMMNDRMIQNQTFNRLREKLSCLESK-AQTDAQI 655

  Fly   864 EAMHIVLRKL-EEKERSLQATVASIEKELMLRQQAMEMHKRKAIESAQSAADLKLHLEKYHAQMK 927
            ..||...:|. ||....|..:|.....||......||.|::...|...|..:.::..::...|||
 Worm   656 AKMHEFEKKANEELVTKLSESVQFKSAELTRLTNLMEQHRKNIQEVGMSRDENQIKADRCEGQMK 720

  Fly   928 EAQQVVAEKTSSLEAEAYKTKRLQEELAQFKRKAERMKKME----MSGTTIDEVMIEEIREYKET 988
            :.|::.|.|...:|...:|.:|.:|||...:.|.||:|:.|    .||   |:|:.|..|:.|||
 Worm   721 QIQELYAAKAREIEDFKFKRQRAEEELETLRIKYERVKRNESVPAQSG---DQVLEEANRQMKET 782

  Fly   989 LTCPSCKVKRKDAVLSKCFHVFCYDCLRTRYETRQRKCPKCNCAFGANDYHRLYL 1043
            |||||||.:.||.::.||:|:||..|::|.|:||||||||||..|||||:||:::
 Worm   783 LTCPSCKTRPKDCIMLKCYHLFCETCIKTMYDTRQRKCPKCNSNFGANDFHRIFI 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bre1	NP_001286950.1	SMC_prok_B	<235..987	CDD:274008	162/776 (21%)
		AAA_23	<654..762	CDD:290211	21/108 (19%)
		zf-C3HC4_2	991..1029	CDD:290634	22/37 (59%)
rfp-1	NP_001022700.1	zf-C3HC4	785..823	CDD:278524	22/37 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164079
Domainoid	1	1.000	129	1.000	Domainoid score	I3283
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8856
Inparanoid	1	1.050	218	1.000	Inparanoid score	I2306
Isobase	1	0.950	-	0	Normalized mean entropy	S3888
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D139233at33208
OrthoFinder	1	1.000	-	-		FOG0001777
OrthoInspector	1	1.000	-	-		oto20810
orthoMCL	1	0.900	-	-		OOG6_103285
Panther	1	1.100	-	-	LDO	PTHR23163
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R146
SonicParanoid	1	1.000	-	-		X1307
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.970