Protein Alignment Bre1 and Bre1

DIOPT Version :10

• Sequence 1: NP_647989.2
• Gene: Bre1 / 38652
• FlyBaseID: FBgn0086694
• Length: 1044
• Species: Drosophila melanogaster
• Sequence 2: XP_308493.5
• Gene: Bre1 / 1269842
• VectorBaseID: AGAMI1_008518
• Length: 1064
• Species: Anopheles gambiae
• Alignment Length: 1120
• Identity: 757/1120 - (67%)
• Similarity: 855/1120 - (76%)
• Gaps: 135/1120 - (12%)

  Fly     1 MSKRSADDATGSSCLVAAAAAG---------------QPPIKKVHFEPHLIGPVSTLEEMDIKVL 50
            ||||||::|.|......|:..|               ||||||||||||||||:|||||:|||||
Mosquito     1 MSKRSAEEAAGGGGGGGASGTGGGAAGTGSGGGGGGLQPPIKKVHFEPHLIGPISTLEELDIKVL 65

  Fly    51 EFQNKKLAQRIEQRMRTEAELRHRIEQLEKRQTQDDAVLNVVNRYWNQLNEDIRVLLQRFDAETA 115
            :|||||||||||||:|.|:|||.||||||||||||||||||||||||||||||||||||||||||
Mosquito    66 KFQNKKLAQRIEQRIRCESELRTRIEQLEKRQTQDDAVLNVVNRYWNQLNEDIRVLLQRFDAETA 130

  Fly   116 DELENRNENEVTTSFLAQLSTWDKEELDEKLANRVQVSKRAVAKIVQVIDRLMQRNEKITHVLKG 180
            ||.||:||||||||||.|||||||||||:|||||||||||||||||||.|||||||||:...|||
Mosquito   131 DESENKNENEVTTSFLMQLSTWDKEELDDKLANRVQVSKRAVAKIVQVFDRLMQRNEKLMLALKG 195

  Fly   181 DSLASAGSGSGAGAGGEEEQQQASGDAETTTSSAGVHALEETLKQTHIEIMSENHKLQNLNTSLH 245
            :|              |:.:..|....:          |:|:|:||:|::|:||..||..||.||
Mosquito   196 ES--------------EDGKSPALAPPD----------LDESLRQTYIDVMAENRNLQTQNTLLH 236

  Fly   246 EKFHTMSLKMKEYQDAHTAKETENAELKNQIDELQYDLEKIHCRNDKLENHLAEAIEKLKAYHQI 310
            |||||:|||:.||||....||||.|||:||||:|||:|||:.||||||||||||||||||||||:
Mosquito   237 EKFHTISLKLSEYQDMLNGKETEAAELRNQIDDLQYELEKVRCRNDKLENHLAEAIEKLKAYHQL 301

  Fly   311 Y-GDP----NKSTNSAKTPTTTGSG----GATTSVNSQLLEELQKELEEYRELANNRLQELDKLH 366
            : |||    ...|.|.:..::.|.|    |:.|||.:|.||:||||||||:||:|||||||||||
Mosquito   302 HGGDPLSGGGSGTESGRHASSAGGGSRGSGSMTSVAAQHLEDLQKELEEYKELSNNRLQELDKLH 366

  Fly   367 ATHRETLKEVEKLKMDIRQLPESVIVETTEYKCLQSQFSVLYNESMQIKTMLDETRNQLQTSKNQ 431
            ..|||.||||||||||||||||||||||||||||||||||||||||||||:|||:|||||:||||
Mosquito   367 LQHREALKEVEKLKMDIRQLPESVIVETTEYKCLQSQFSVLYNESMQIKTLLDESRNQLQSSKNQ 431

  Fly   432 HLRQIEVMESEELIAQKKVRSEMIQMEDVLALIRKEYETLRIEFEQNMAANEQTAPINREMRHLI 496
            ||||||:||||||||||:|||:|||||||::.||||||.|||||||||||||||||||.||||||
Mosquito   432 HLRQIEMMESEELIAQKRVRSDMIQMEDVMSQIRKEYEMLRIEFEQNMAANEQTAPINHEMRHLI 496

  Fly   497 TSLQNHNGQLKGEVQRYKRKYKDTSTDNLKLRQELADALATLEGNKLQAATGA----------AG 551
            .|||||||||||||||||:||||.|.||.|||::|.:     :..|:.|...|          ..
Mosquito   497 LSLQNHNGQLKGEVQRYKKKYKDVSADNTKLRKDLEE-----QTGKVTALQEAQQQHQQQQQQQQ 556

  Fly   552 EEIKQENSTGVKEENSNNVSASGQTNQTNSGNDTNVAIKEENHISAEDEADDEASGKDVKDG--- 613
            ::.:|:::..:|.||.:::..:|  .....|....:::|||:.....|           :||
Mosquito   557 QQQQQQHAESIKLENCHSMRDAG--GGGGGGGGGGMSVKEESGGMLHD-----------RDGQCG 608

  Fly   614 -IKQEKLSSG--------------------------DAAAAEKKDSPGPGNSTSSATNSVPVKNE 651
             ||:|..:.|                          ||...::::..||     ..|..:.||.|
Mosquito   609 AIKEEDPNGGLNSCGGHGATSTGSLTRSDSGEEGEMDANGIKREEMIGP-----DGTVVMVVKRE 668

  Fly   652 KDSKDGVKGKD------------VKAVESETVRDLKAQLKKALNDQKEMKLLLDMYKGVSKDQRD 704
            ..|..||...|            ||..||:.||||:.||||||||||||||||||||||.|:|||
Mosquito   669 GSSGGGVGSMDGKANGPTDHHRGVKCAESDLVRDLRNQLKKALNDQKEMKLLLDMYKGVPKEQRD 733

  Fly   705 KVQLMATEKKLRSEIEELRQQLKKLQESKREERKKLADEEALRKIKQLEEQKYELQKQMANHK-P 768
            ||||||:|||..:|||:|:.|:|||||||||:||||||||||||||||||||||||||:.|.| |
Mosquito   734 KVQLMASEKKKCAEIEDLKCQMKKLQESKREDRKKLADEEALRKIKQLEEQKYELQKQVQNQKQP 798

  Fly   769 TDNSWGSGAPGTANYTRPFVGSHEEEALLNEMEVTGQAFEDMQEQNSRLIQQLREKDDANFKLMS 833
            .|:||.||       .|||    ||||||||||||||||||||||||||||||||||||||||||
Mosquito   799 PDSSWSSG-------YRPF----EEEALLNEMEVTGQAFEDMQEQNSRLIQQLREKDDANFKLMS 852

  Fly   834 ERIKANQLHKLLREEKTVLEDQMATATTQIEAMHIVLRKLEEKERSLQATVASIEKELMLRQQAM 898
            :||||||:||||||||.:||||:.|..:||||||:||||||||||.||.||.:|||||:.|||||
Mosquito   853 DRIKANQMHKLLREEKQLLEDQVTTRDSQIEAMHVVLRKLEEKERILQNTVTTIEKELVARQQAM 917

  Fly   899 EMHKRKAIESAQSAADLKLHLEKYHAQMKEAQQVVAEKTSSLEAEAYKTKRLQEELAQFKRKAER 963
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||:|
Mosquito   918 EMHKRKAIESAQSAADLKLHLEKYHAQMKEAQQVVAEKTSSLEAEAYKTKRLQEELAQFRRKADR 982

  Fly   964 MKKMEMSGTTIDEVMIEEIREYKETLTCPSCKVKRKDAVLSKCFHVFCYDCLRTRYETRQRKCPK 1028
            |||:|||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||
Mosquito   983 MKKIEMSGTTIDEVMLEEIREYKETLTCPSCKVKRKDAVLSKCFHVFCYDCLRTRYETRQRKCPK 1047

  Fly  1029 CNCAFGANDYHRLYL 1043
            |||||||||||||||
Mosquito  1048 CNCAFGANDYHRLYL 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bre1	NP_647989.2	SMC_prok_B	<235..987	CDD:274008	535/813 (66%)
		RING-HC_dBre1-like	975..1043	CDD:438365	66/67 (99%)
Bre1	XP_308493.5	None