DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bre1 and Rnf20

DIOPT Version :9

Sequence 1:	NP_001286950.1	Gene:	Bre1 / 38652	FlyBaseID:	FBgn0086694	Length:	1044	Species:	Drosophila melanogaster
Sequence 2:	NP_001156735.1	Gene:	Rnf20 / 109331	MGIID:	1925927	Length:	973	Species:	Mus musculus

Alignment Length:	1077	Identity:	464/1077 - (43%)
Similarity:	654/1077 - (60%)	Gaps:	166/1077 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 AAGQ-----PPIKKVHFEPH-------LIGPVSTLEEMDIKVLEFQNKKLAQRIEQRMRTEAELR 72
            |||:     ||.||...|..       .:|.||:.||:||:.|:.:|:|||:.::||...|.|||
Mouse     9 AAGEPGTSMPPEKKTAVEDSGTTVETIKLGGVSSTEELDIRTLQSKNRKLAEMLDQRQAIEDELR 73

  Fly    73 HRIEQLEKRQTQDDAVLNVVNRYWNQLNEDIRVLLQRFD-------------------------- 111
            ..||:||:||..|||.|.:|||||:|.:|:||::|:|:|
Mouse    74 EHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKRYDLDQGLGDLLTERKALVVPEPEPDSDS 138

  Fly   112 -AETADELENRNENEVTTSFLAQLSTWDKEELDEKLANRVQVSKRAVAKIVQVIDRLMQRNEKIT 175
             .|..|:.|..:..|...||||.|::...||::.:|..||:.|:|||::||.|.|:|.::.:.::
Mouse   139 NQERKDDRERGDGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVDLLS 203

  Fly   176 HVL-KGDSLASAGSGSGAGAGGEEEQQQASGDAETTTSSAGVHALEETLKQTHIEIMSENHKLQN 239
            ..| .||:|                                  .:||.:::.:..:..||.:||.
Mouse   204 RKLNSGDNL----------------------------------IVEEAVQELNSFLAQENVRLQE 234

  Fly   240 LNTSLHEKFHTMSLKMKEYQDAHTAKETENAELKNQIDELQYDLEKIHCRNDKLENHLAEAIEKL 304
            |...|.||.||||.:..:.|......|:..:.|::.||:||:|::||..|..:|..||||.:|::
Mouse   235 LTDLLQEKHHTMSQEFCKLQGKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERV 299

  Fly   305 --KAYHQIYGDPNKSTNSAKTPTTTGSG--GATTSVNSQLLEELQKELEEYRELANNRLQELDKL 365
              |.| ::||              .||.  |.|.::|::..||:..||||.:|||.||..||:||
Mouse   300 NSKGY-KVYG--------------AGSSLYGGTITINARKFEEMNAELEENKELAQNRHCELEKL 349

  Fly   366 HATHRETLKEVEKLKMDIRQLPESVIVETTEYKCLQSQFSVLYNESMQIKTMLDETRNQLQTSKN 430
            .....|...:.||||:::|...|.|:.||.||:|:|||||||||||:|:|..|||.|..|..::.
Mouse   350 RQDFEEVTTQNEKLKVELRSAVEEVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRG 414

  Fly   431 QHLRQIEVMESEELIAQKKVRSEMIQMEDVLALIRKEYETLRIEFEQNMAANEQTAPINREMRHL 495
            .|.||:|::|.:|:...||:|:|:||:||.||.:|||||.|||||||.:|||||..|||||||||
Mouse   415 THQRQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHL 479

  Fly   496 ITSLQNHNGQLKGEVQRYKRKYKDTSTDNLKLRQELADALATLEGNKLQAATGAAGEEIKQENST 560
            |:||||||.||||||.|||||.::..:|..|.|.....||       ||:.:..  |:.|.| .|
Mouse   480 ISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSAL-------LQSQSST--EDPKDE-PT 534

  Fly   561 GVKEE------NSNNVSASGQTNQTNSGNDTNVAIKEENHISAEDEADDEASGKDVKDGIKQEKL 619
            .:|::      :|:.:.|| |.::..|..|             |:|.:.|...|:.:...::||.
Mouse   535 ELKQDSEDLATHSSALKAS-QEDEVKSKRD-------------EEERERERREKEREREREREKE 585

  Fly   620 SSGDAAAAEKKDSPGPGNSTSSATNSVPVKNEKDS-KDGVKGK--DVKAVESETVRDLKAQLKKA 681
            ...:....:.|:|                :.|:|| ||..|||  |.:..|:|.::.||.:||||
Mouse   586 KEREREKQKLKES----------------EKERDSVKDKEKGKHDDGRKKEAEIIKQLKIELKKA 634

  Fly   682 LNDQKEMKLLLDMYKGVSKDQRDKVQLMATEKKLRSEIEELRQQLKKLQESKREERKKLADEEAL 746
            ...|||||||||||:...|:|||||||||.|||.::|:|:|||:||.|::.:::|.||:|||:||
Mouse   635 QESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDAL 699

  Fly   747 RKIKQLEEQKYELQKQMANHKPTDNSWGSGAPGTANYTRPFVGSHEEEALLNEMEVTGQAFEDMQ 811
            |||:.:|||...|||::|                       :...||||||:||:||||||||||
Mouse   700 RKIRAVEEQIEYLQKKLA-----------------------MAKQEEEALLSEMDVTGQAFEDMQ 741

  Fly   812 EQNSRLIQQLREKDDANFKLMSERIKANQLHKLLREEKTVLEDQMATATTQIEAMHIVLRKLEEK 876
            |||.||:|||||||||||||||||||:||:||||:|||..|.||:.|..||::|...|:||||||
Mouse   742 EQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEK 806

  Fly   877 ERSLQATVASIEKELMLRQQAMEMHKRKAIESAQSAADLKLHLEKYHAQMKEAQQVVAEKTSSLE 941
            |..||:.:.:.||||.||.||:||:||||:|:||.|.|||..||....::.:.|..:.|.:.:.|
Mouse   807 EHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKE 871

  Fly   942 AEAYKTKRLQEELAQFKRKAERMKKMEMSGTTIDEVMIEEIREYKETLTCPSCKVKRKDAVLSKC 1006
            .:.:..||.||::::.:||.|..||.: :....||:::|||::||..||||.|.:::|||||:||
Mouse   872 KDLFNFKRAQEDISRLRRKLETTKKPD-NVPKCDEILMEEIKDYKARLTCPCCNMRKKDAVLTKC 935

  Fly  1007 FHVFCYDCLRTRYETRQRKCPKCNCAFGANDYHRLYL 1043
            |||||::|::|||:||||||||||.||||||:||:|:
Mouse   936 FHVFCFECVKTRYDTRQRKCPKCNAAFGANDFHRIYI 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bre1	NP_001286950.1	SMC_prok_B	<235..987	CDD:274008	344/764 (45%)
		AAA_23	<654..762	CDD:290211	63/110 (57%)
		zf-C3HC4_2	991..1029	CDD:290634	26/37 (70%)
Rnf20	NP_001156735.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		8/27 (30%)
		Smc	<41..394	CDD:224117	141/401 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..153		3/24 (13%)
		PTZ00121	<320..934	CDD:173412	320/677 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	507..620		35/152 (23%)
		RING-HC_RNF20_like	918..963	CDD:319618	32/44 (73%)
		RING-HC finger (C3HC4-type)	920..958	CDD:319618	26/37 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845956
Domainoid	1	1.000	711	1.000	Domainoid score	I117
eggNOG	1	0.900	-	-		E1_KOG0978
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	809	1.000	Inparanoid score	I484
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001777
OrthoInspector	1	1.000	-	-		otm43489
orthoMCL	1	0.900	-	-		OOG6_103285
Panther	1	1.100	-	-	O	PTHR23163
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R146
SonicParanoid	1	1.000	-	-		X1307
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780