DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bre1 and rnf40

DIOPT Version :9

Sequence 1:	NP_001286950.1	Gene:	Bre1 / 38652	FlyBaseID:	FBgn0086694	Length:	1044	Species:	Drosophila melanogaster
Sequence 2:	XP_002940628.1	Gene:	rnf40 / 100380175	XenbaseID:	XB-GENE-1013821	Length:	991	Species:	Xenopus tropicalis

Alignment Length:	1100	Identity:	476/1100 - (43%)
Similarity:	667/1100 - (60%)	Gaps:	173/1100 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SKR-SADDATGSSCLVAAAAAGQPPIKKVHFEPHLIGPVSTLEEMDIKVLEFQNKKLAQRIEQRM 65
            ||| |:|:.:|.|.......|..|   ....||..:|.:|:.||||:|||:|:|||||:|:|||.
Frog     6 SKRASSDNGSGPSEKKPNLEAKTP---TTLIEPIRLGGISSTEEMDMKVLQFKNKKLAERLEQRQ 67

  Fly    66 RTEAELRHRIEQLEKRQTQDDAVLNVVNRYWNQLNEDIRVLLQRFDAE----------TADELEN 120
            ..|.|||.:||:|||||..|||.|.:|||||::|:||:.|||:|:|:|          ..:|.|:
Frog    68 GFEDELREKIEKLEKRQATDDATLLIVNRYWSKLDEDVHVLLKRYDSEPSKQSAAPSAATEEPES 132

  Fly   121 RNENEVTT--------------------------------------SFLAQLSTWDKEELDEKLA 147
            ..|..:.|                                      :|||.|:...|||::.||.
Frog   133 AKETAMETDESAEGSQPPPTQEIKAASPEPPPAPPFSTGALPESSLTFLATLAHCTKEEIELKLQ 197

  Fly   148 NRVQVSKRAVAKIVQVIDRLMQRNEKI-THVLKGDSLASAGSGSGAGAGGEEEQQQASGDAETTT 211
            .|::.||:||:.:::..::|..|.|:: ..:.|||
Frog   198 ERMEFSKKAVSCVLETSNKLHCRTEELCDRIHKGD------------------------------ 232

  Fly   212 SSAGVHALEETLKQTHIEIMSENHKLQNLNTSLHEKFHTMSLKMKEYQDAHTAKETENAELKNQI 276
                ...|.|:.|:.:.|:::||.:||:|.|.|.||.|.:||:..|.||..|:.||:.:|::..|
Frog   233 ----FDHLGESPKKLNKELITENRRLQDLATVLQEKHHRLSLQHHELQDRATSTETKVSEMERTI 293

  Fly   277 DELQYDLEKIHCRNDKLENHLAEAIEKLKAYHQIYGDPNKSTNSAKTPTTTGS--GGATTSVNSQ 339
            ::||:|:||:.....||..|||||:|:|.:.:.|.|             ::||  ||.|| ::.|
Frog   294 EDLQWDIEKLRKHEQKLNRHLAEALEQLNSGYHISG-------------SSGSFQGGQTT-LSMQ 344

  Fly   340 LLEELQKELEEYRELANNRLQELDKLHATHRETLKEVEKLKMDIRQLPESVIVETTEYKCLQSQF 404
            ..|.|..||::.:||||:|:.||:||....:..::..||||:|:|.|||..:..|.:::||||||
Frog   345 KFEMLNAELDQNQELANSRISELEKLQNELQAAVRLKEKLKLDLRTLPEEAVRNTQDFRCLQSQF 409

  Fly   405 SVLYNESMQIKTMLDETRNQLQTSKNQHLRQIEVMESEELIAQKKVRSEMIQMEDVLALIRKEYE 469
            |:|||||:|:||.|||.|..|.::||.||||||.||||||..|||:|:|:||:||.||.:|||||
Frog   410 SLLYNESLQVKTQLDEARALLLSTKNSHLRQIERMESEELSVQKKLRTEVIQLEDTLAQVRKEYE 474

  Fly   470 TLRIEFEQNMAANEQTAPINREMRHLITSLQNHNGQLKGEVQRYKRKYKDTSTDNLKLRQELADA 534
            .||||||||:|||||..||||||||||.||||||.||||:|||||||.:|:..:..|||.::
Frog   475 MLRIEFEQNLAANEQAGPINREMRHLIGSLQNHNHQLKGDVQRYKRKVRDSQAEVSKLRFQI--- 536

  Fly   535 LATLEGNKLQAATGAAGEE------IKQENSTGVKEENSNNVSASGQTNQTNSGNDTNVAIKEEN 593
                 |.......|::|.|      :|:| ...||:|....|....:|       .|...:|:|
Frog   537 -----GGPPCPQPGSSGSEPTTPVTVKEE-EVEVKKEPLAVVPREPET-------PTTPEVKKE- 587

  Fly   594 HISAEDEADDEASGKDVKDGIKQEKLSSGDAAAAEKKDSPGPGNSTSSATNSVPVKNEKDSKDGV 658
                |:|...||:          |:..:.:..|..::|.....:..         |..:..||..
Frog   588 ----EEEQKKEAA----------ERTKAREREAERERDKDRERDKE---------KEREREKDKQ 629

  Fly   659 KGKDVKAVESETVRDLKAQLKKALNDQKEMKLLLDMYKGVSKDQRDKVQLMATEKKLRSEIEELR 723
            |..:.|..:.:.::.|:|:||||...||||||||||||...|:|||||||||.|:|.::|:||.|
Frog   630 KTDESKRKDCDILKQLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKTKAEMEEQR 694

  Fly   724 QQLKKLQESKREERKKLADEEALRKIKQLEEQKYELQKQMANHKPTDNSWGSGAPGTANYTRPFV 788
            .:::.|:|..:.|||||||||||||||..|||...||:::...|
Frog   695 TRVQALEEKDKRERKKLADEEALRKIKMAEEQIDHLQRKLTATK--------------------- 738

  Fly   789 GSHEEEALLNEMEVTGQAFEDMQEQNSRLIQQLREKDDANFKLMSERIKANQLHKLLREEKTVLE 853
              .||||||:||:|||||||||||||.||:|||||||||||||||||||:||:||||||||..|.
Frog   739 --QEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLREEKEELA 801

  Fly   854 DQMATATTQIEAMHIVLRKLEEKERSLQATVASIEKELMLRQQAMEMHKRKAIESAQSAADLKLH 918
            :|:.....|::|..:.::||||:||.|..::.|||||:.||.|::|::||||:|:||.|.|||:.
Frog   802 EQVQGLKAQVDAQLLQVQKLEERERLLHTSLTSIEKEVTLRTQSLELNKRKAVEAAQLAEDLKVQ 866

  Fly   919 LEKYHAQMKEAQQVVAEKTSSLEAEAYKTKRLQEELAQFKRKAERMKKMEMSGTTIDEVMIEEIR 983
            :|.....:::.|..|.|..|:.|.|::..||.||::::.:||.|:.||||:.... |:::.|||:
Frog   867 MEHVGETLRDTQNFVCENRSAKEKESFSLKRAQEDVSRLRRKLEKQKKMEVYADA-DQILQEEIK 930

  Fly   984 EYKETLTCPSCKVKRKDAVLSKCFHVFCYDCLRTRYETRQRKCPKCNCAFGANDYHRLYL 1043
            ||:..||||.|..::|||||:|||||||::|::||||:|||||||||.||||:|:||:|:
Frog   931 EYRARLTCPCCNTRKKDAVLTKCFHVFCFECVKTRYESRQRKCPKCNAAFGAHDFHRIYI 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bre1	NP_001286950.1	SMC_prok_B	<235..987	CDD:274008	348/759 (46%)
		AAA_23	<654..762	CDD:290211	60/107 (56%)
		zf-C3HC4_2	991..1029	CDD:290634	26/37 (70%)
rnf40	XP_002940628.1	SMC_prok_B	<245..910	CDD:274008	340/741 (46%)
rnf40	XP_002940628.1	RING_Ubox	935..989	CDD:388418	38/53 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	696	1.000	Domainoid score	I127
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8856
Inparanoid	1	1.050	797	1.000	Inparanoid score	I494
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D139233at33208
OrthoFinder	1	1.000	-	-		FOG0001777
OrthoInspector	1	1.000	-	-		otm48650
Panther	1	1.100	-	-	LDO	PTHR23163
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1307
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.070