DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cralbp and SEC14L5

DIOPT Version :9

Sequence 1:	NP_523939.1	Gene:	Cralbp / 38651	FlyBaseID:	FBgn0035636	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_055507.1	Gene:	SEC14L5 / 9717	HGNCID:	29032	Length:	696	Species:	Homo sapiens

Alignment Length:	351	Identity:	74/351 - (21%)
Similarity:	128/351 - (36%)	Gaps:	93/351 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DRC------TREQSLEQLRNWVAKNEDLQNVRCDDTFLLRFLRAKKFSVPMAEQTLLKYLNIRRT 84
            :||      .:|..|.|||:|:  .|..:.....|..:||||||..|.:..|.:.|.:.|:.|:
Human   232 ERCLGHLTPMQESCLIQLRHWL--QETHKGKIPKDEHILRFLRAHDFHLDKAREMLRQSLSWRK- 293

  Fly    85 FPHMSTQLDYL-----EPRLGDLIDQG------------YIFAVPQRDKHG-----------RRV 121
                ..|:|.|     .|.|.:....|            ||..:.|.|..|           |.|
Human   294 ----QHQVDLLLQTWQPPALLEEFYAGGWHYQDIDGRPLYILRLGQMDTKGLMKAVGEEALLRHV 354

  Fly   122 VVINAKGLNPKIHTSCDQAKAHFLTYECLMEDQETQITGLTHVGDFAGVTTAHVTNWNP--TEFA 184
            :.:|.:| ..:...|..|......::.||:              |..|:...|:  |.|  ....
Human   355 LSVNEEG-QKRCEGSTRQLGRPISSWTCLL--------------DLEGLNMRHL--WRPGVKALL 402

  Fly   185 RIFKWGEQSLPMRHKEIHLINVPSTLKWLIDFVKNRVSSKMKNRLIIY-GSEKE----LMKSVDQ 244
            |:.:..|.:.|.....:.::..|.....|...:...::...:.:.:|| ||..:    |:..:|:
Human   403 RMIEVVEDNYPETLGRLLIVRAPRVFPVLWTLISPFINENTRRKFLIYSGSNYQGPGGLVDYLDR 467

  Fly   245 GCLP----------LEMGGKVPMREMIELWKQELATKRDLILGLDKSILRSDRGIQRRSSFNAGK 299
            ..:|          :..||.||....:...:||                .:|:..|...::::..
Human   468 EVIPDFLGGESVCNVPEGGLVPKSLYMTEEEQE----------------HTDQLWQWSETYHSAS 516

  Fly   300 ASTGGPNFVSQIESIEG-SFRKLEFD 324
            ...|.|:.|: :|.:|| |....:||
Human   517 VLRGAPHEVA-VEILEGESVITWDFD 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cralbp	NP_523939.1	CRAL_TRIO_N	31..78	CDD:215024	17/46 (37%)
Cralbp	NP_523939.1	SEC14	101..254	CDD:238099	32/192 (17%)
SEC14L5	NP_055507.1	PRELI	17..173	CDD:309720
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..214
		CRAL_TRIO_N	243..288	CDD:215024	17/46 (37%)
		SEC14	306..479	CDD:214706	33/189 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810