DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cralbp and Sec14l1

DIOPT Version :9

Sequence 1:	NP_523939.1	Gene:	Cralbp / 38651	FlyBaseID:	FBgn0035636	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_083053.2	Gene:	Sec14l1 / 74136	MGIID:	1921386	Length:	719	Species:	Mus musculus

Alignment Length:	381	Identity:	81/381 - (21%)
Similarity:	141/381 - (37%)	Gaps:	91/381 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GLPEALL--KIAKRELREDRCTREQSLEQLRNWVAKNEDLQNVRCDDTFLLRFLRAKKFSVPMAE 72
            |.|:..|  ...||.|.:....:|..|.:||.|:  .|..:.....|..:||||||:.|::..|.
Mouse   233 GTPDDKLDADYIKRYLGDLTPLQESCLIRLRQWL--QETHKGKIPKDEHILRFLRARDFNIDKAR 295

  Fly    73 QTLLKYLNIRRTFPHMSTQLDYL-----EPRLGDLIDQGYIFAVPQRDKHGRRVVVI-----NAK 127
            :.:.:.|..|:     ..|:||:     .|::  |:|. |.......||.||.:.|:     :.|
Mouse   296 EIMCQSLTWRK-----QHQVDYILDTWTPPQV--LLDY-YAGGWHHHDKDGRPLYVLRLGQMDTK 352

  Fly   128 GLNPKIHTSCDQAKAHF---LTYECLMEDQET------QITGLTHVGDFAGVTTAHVTNWNP--T 181
            ||   :....::|...:   :..|.|...:|.      .|:..|.:.|..|:...|:  |.|  .
Mouse   353 GL---VRALGEEALLRYVLSINEEGLRRCEENTKVFGRPISSWTCLVDLEGLNMRHL--WRPGVK 412

  Fly   182 EFARIFKWGEQSLPMRHKEIHLINVPSTLKWLIDFVKNRVSSKMKNRLIIY-GSEKE----LMKS 241
            ...||.:..|.:.|.....:.::..|.....|...|...:....:.:.:|| |::.:    |:..
Mouse   413 ALLRIIEVVEANYPETLGRLLILRAPRVFPVLWTLVSPFIDDNTRRKFLIYAGNDYQGPGGLLDY 477

  Fly   242 VDQGCLP----------LEMGGKVPM----------REMIELWKQELATKRDLILGLDKSIL--- 283
            :|:..:|          :..||.||.          .|.::||.:.:.....:..|....||
Mouse   478 IDKEIIPDFLSGECMCDVPEGGLVPKSLYRTAEELENEDLKLWTETIYQSASVFKGAPHEILIQI 542

  Fly   284 -----------------------RSDRGIQ--RRSSFNAGKASTGGPNFVSQIESI 314
                                   .|.|..|  ::.|..|...::.|.|.|..|:.:
Mouse   543 VDASSVITWDFDVCKGDIVFNIYHSKRSPQPPKKDSLGAHSITSPGGNNVQLIDKV 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cralbp	NP_523939.1	CRAL_TRIO_N	31..78	CDD:215024	15/46 (33%)
Cralbp	NP_523939.1	SEC14	101..254	CDD:238099	36/183 (20%)
Sec14l1	NP_083053.2	Required for interaction and inhibitory function toward DDX58. /evidence=ECO:0000250\|UniProtKB:Q92503	1..510		66/291 (23%)
		PRELI	17..173	CDD:282550
		CRAL_TRIO_N	256..301	CDD:215024	15/46 (33%)
		CRAL_TRIO	326..490	CDD:279044	33/169 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810