DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cralbp and SEC14L1

DIOPT Version :9

Sequence 1:	NP_523939.1	Gene:	Cralbp / 38651	FlyBaseID:	FBgn0035636	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_001034662.3	Gene:	SEC14L1 / 6397	HGNCID:	10698	Length:	719	Species:	Homo sapiens

Alignment Length:	394	Identity:	81/394 - (20%)
Similarity:	137/394 - (34%)	Gaps:	117/394 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GLPEALL--KIAKRELREDRCTREQSLEQLRNWVAKNEDLQNVRCDDTFLLRFLRAKKFSVPMAE 72
            |.|:..|  ...||.|.:....:|..|.:||.|:  .|..:.....|..:||||||:.|::..|.
Human   233 GTPDDKLDADYIKRYLGDLTPLQESCLIRLRQWL--QETHKGKIPKDEHILRFLRARDFNIDKAR 295

  Fly    73 QTLLKYLNIRRTFPHMSTQLDYL-----EPR-LGDLIDQG-----------YIFAVPQRDKHG-- 118
            :.:.:.|..|:     ..|:||:     .|: |.|....|           |:..:.|.|..|
Human   296 EIMCQSLTWRK-----QHQVDYILETWTPPQVLQDYYAGGWHHHDKDGRPLYVLRLGQMDTKGLV 355

  Fly   119 ---------RRVVVINAKGLNPKIHTSCDQAKAHF----LTYECLMEDQETQITGLTHVGDFAGV 170
                     |.|:.||.:||.     .|::....|    .::.||:              |..|:
Human   356 RALGEEALLRYVLSINEEGLR-----RCEENTKVFGRPISSWTCLV--------------DLEGL 401

  Fly   171 TTAHVTNWNP--TEFARIFKWGEQSLPMRHKEIHLINVPSTLKWLIDFVKNRVSSKMKNRLIIY- 232
            ...|:  |.|  ....||.:..|.:.|.....:.::..|.....|...|...:....:.:.:||
Human   402 NMRHL--WRPGVKALLRIIEVVEANYPETLGRLLILRAPRVFPVLWTLVSPFIDDNTRRKFLIYA 464

  Fly   233 GSEKE----LMKSVDQGCLP----------LEMGGKVPM----------REMIELWKQELATKRD 273
            |::.:    |:..:|:..:|          :..||.||.          .|.::||.:.:.....
Human   465 GNDYQGPGGLLDYIDKEIIPDFLSGECMCEVPEGGLVPKSLYRTAEELENEDLKLWTETIYQSAS 529

  Fly   274 LILGLDKSIL--------------------------RSDRGIQ--RRSSFNAGKASTGGPNFVSQ 310
            :..|....||                          .|.|..|  ::.|..|...::.|.|.|..
Human   530 VFKGAPHEILIQIVDASSVITWDFDVCKGDIVFNIYHSKRSPQPPKKDSLGAHSITSPGGNNVQL 594

  Fly   311 IESI 314
            |:.:
Human   595 IDKV 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cralbp	NP_523939.1	CRAL_TRIO_N	31..78	CDD:215024	15/46 (33%)
Cralbp	NP_523939.1	SEC14	101..254	CDD:238099	35/195 (18%)
SEC14L1	NP_001034662.3	PRELI	17..173	CDD:368069
		CRAL_TRIO_N	256..301	CDD:215024	15/46 (33%)
		CRAL_TRIO	326..490	CDD:366224	33/184 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810