DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cralbp and CLVS1

DIOPT Version :9

Sequence 1:	NP_523939.1	Gene:	Cralbp / 38651	FlyBaseID:	FBgn0035636	Length:	324	Species:	Drosophila melanogaster
Sequence 2:	NP_775790.1	Gene:	CLVS1 / 157807	HGNCID:	23139	Length:	354	Species:	Homo sapiens

Alignment Length:	289	Identity:	76/289 - (26%)
Similarity:	134/289 - (46%)	Gaps:	13/289 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GLPEALLKIAKRELREDRCTREQSLEQLRNWVAKNEDLQNVRCDDTFLLRFLRAKKFSVPMAEQT 74
            ||....::.|:.||.|:.....|.::|:|:.:....|:..:|.||.|:||||||:||....|.:.
Human    29 GLSPETIEKARLELNENPDVLHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRL 93

  Fly    75 LLKYLNIRRTFPHMSTQLDYLEPRLGDLIDQGYIFAVPQRDKHGRRVVVINAKGLNPKIHTSCDQ 139
            |.:|...|:....|.......:|.:...:..|:...:..||.:||:::::.|...:...::..|.
Human    94 LAQYFQYRQLNLDMFKNFKADDPGIKRALIDGFPGVLENRDHYGRKILLLFAANWDQSRNSFTDI 158

  Fly   140 AKAHFLTYECLMEDQETQITGLTHVGDFAGVTTAHVTNWNPTEFARIFKWGEQSLPMRHKEIHLI 204
            .:|..|:.|.|:||.|.||.|...:.|::..:....:...|:......:..:.|.|.|...:|.:
Human   159 LRAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFGGVHFV 223

  Fly   205 NVPSTLKWLIDFVKNRVSSKMKNRLIIYGSE-KELMKSVDQGCLPLEMGGKVPMREMIELWKQEL 268
            |.|..:..|...:|..:..|.:.|:.::|:. ..|.:.:....||.|.||.:|..:| ..|.:.|
Human   224 NQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGGTLPPYDM-GTWARTL 287

  Fly   269 ATKRDLILGLDKSILRSDRGIQRRSSFNA 297
                   ||.|    .||......:|:||
Human   288 -------LGPD----YSDENDYTHTSYNA 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cralbp	NP_523939.1	CRAL_TRIO_N	31..78	CDD:215024	18/46 (39%)
Cralbp	NP_523939.1	SEC14	101..254	CDD:238099	35/153 (23%)
CLVS1	NP_775790.1	CRAL_TRIO_N	51..97	CDD:215024	18/45 (40%)
		CRAL_TRIO	125..274	CDD:306996	35/148 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..354
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	144	1.000	Inparanoid score	I4448
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10174
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X106
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.970