DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myt1 and PKMYT1

DIOPT Version :9

Sequence 1:	NP_647987.2	Gene:	Myt1 / 38649	FlyBaseID:	FBgn0040298	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_004194.3	Gene:	PKMYT1 / 9088	HGNCID:	29650	Length:	499	Species:	Homo sapiens

Alignment Length:	451	Identity:	174/451 - (38%)
Similarity:	244/451 - (54%)	Gaps:	62/451 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 ISFRDAGCSDSSTLPS---SPVQAELSTLSLSHFEQCFERLAKLGEGSFGEVFQVRDRSDGQLYA 129
            :|||...   |.||.|   .|.:.|      |.|:|.|:||::||.||:||||:||.:.||:|||
Human    82 VSFRGEA---SETLQSPGYDPSRPE------SFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYA 137

  Fly   130 VKISKQLFRGEQYRAERLEEVRRYEEFSGHENCIRFIRAWEQYDRLYMQMELCRESLEQYLLRCQ 194
            ||.|...|||.:.||.:|.||..:|:...|..|:|..:|||:...||:|.|||..||:|:   |:
Human   138 VKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQH---CE 199

  Fly   195 ----RIPEERIWHILLDLLRGLKSLHDRNLIHLDIKLDNVLIGEDDETCKLADFGLVIDVDRANS 255
                .:||.::|..|.|.|..|..||.:.|:|||:|..|:.:|.... |||.||||::::..|.:
Human   200 AWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGR-CKLGDFGLLVELGTAGA 263

  Fly   256 HHATEGDSRYMAPEILQGHFSKAADIFSLGIAMLELACYMDLPSNGPLWHELRHGILPEEFINKI 320
            ....|||.||||||:|||.:..|||:||||:.:||:||.|:||..|..|.:||.|.||.||...:
Human   264 GEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGL 328

  Fly   321 SLELQSVIKSMMKPDPAQRPTAEQLLSHPKLQYLQKKRKSL---MNFSMLSRSFRRSRRAVW--- 379
            |.||:||:..|::|||..|.|||.||:.|.|:  |.:...:   |....|||.:     |:|
Human   329 SSELRSVLVMMLEPDPKLRATAEALLALPVLR--QPRAWGVLWCMAAEALSRGW-----ALWQAL 386

  Fly   380 -GRMCNWKTAAFRYLLYFLEVLHLCKPIT--ASQPNINIVPSSPSSK------GVPLVPQ-VEFQ 434
             ..:| |......:...:|:.|.  .|.|  .|.|...::.||.||.      |..|.|: |..:
Human   387 LALLC-WLWHGLAHPASWLQPLG--PPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLAR 448

  Fly   435 LVGSTPIANRDCYASDFLSGEDPLDLSNQGSPNVINSTP----LNTNQGKSRLDLLKNNVD 491
            .||||......|      :..|.||||:      |||.|    ..:.:.::.|.|.::.:|
Human   449 TVGSTSTPRSRC------TPRDALDLSD------INSEPPRGSFPSFEPRNLLSLFEDTLD 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myt1	NP_647987.2	PKc_Myt1	100..349	CDD:270952	121/252 (48%)
Myt1	NP_647987.2	Pkinase	102..349	CDD:278497	120/250 (48%)
PKMYT1	NP_004194.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..72
		PKc_Myt1	108..357	CDD:270952	121/252 (48%)
		Membrane-association motif	382..398		3/16 (19%)
		Interaction with PIN1	398..499		31/114 (27%)
		Interaction with CDC2-CCNB1	437..499		21/73 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..485		13/45 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160014
Domainoid	1	1.000	237	1.000	Domainoid score	I2338
eggNOG	1	0.900	-	-		E1_KOG0601
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	246	1.000	Inparanoid score	I3285
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063695at2759
OrthoFinder	1	1.000	-	-		FOG0003337
OrthoInspector	1	1.000	-	-		oto89991
orthoMCL	1	0.900	-	-		OOG6_104974
Panther	1	1.100	-	-	LDO	PTHR11042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1671
SonicParanoid	1	1.000	-	-		X4326
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790