DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myt1 and IRE1

DIOPT Version :9

Sequence 1:	NP_647987.2	Gene:	Myt1 / 38649	FlyBaseID:	FBgn0040298	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_011946.1	Gene:	IRE1 / 856478	SGDID:	S000001121	Length:	1115	Species:	Saccharomyces cerevisiae

Alignment Length:	454	Identity:	97/454 - (21%)
Similarity:	162/454 - (35%)	Gaps:	144/454 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 RFR--PPKY---KTRGYVAVDNNNLNRSQSLGSCSTNSSQIAHAISFRDA------GCSDSSTLP 82
            ||:  ||.|   ...|::......:..|:|| :|.::|..:......:..      |..:..:|.
Yeast   557 RFKILPPLYVLLSKIGFMPEKEIPIVESKSL-NCPSSSENVTKPFDMKSGKQVVFEGAVNDGSLK 620

  Fly    83 S----------SPVQAELST--------------------LSLSHFEQCFERLAK----LGEGSF 113
            |          .....:|:|                    .::.:|||..:.|..    ||.||.
Yeast   621 SEKDNDDADEDDEKSLDLTTEKKKRKRGSRGGKKGRKSRIANIPNFEQSLKNLVVSEKILGYGSS 685

  Fly   114 GEVFQVRDRSDGQLYAVKISKQLFRGEQYRAER---------LEEVRRYEEFSGHENCIRFIRAW 169
            |.|               :.:..|:|.....:|         |.|::...|...|.|.||:..:
Yeast   686 GTV---------------VFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYYCS- 734

  Fly   170 EQYDR-LYMQMELCRESLEQYLLRCQRIPEERI--------WHILLDLLRGLKSLHDRNLIHLDI 225
            |..|| ||:.:|||..:| |.|:..:.:.:|.:        ..:|..:..|:..||...:||.|:
Yeast   735 ETTDRFLYIALELCNLNL-QDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSLKIIHRDL 798

  Fly   226 KLDNVLI------------GEDDETCKLADFGLVIDVDRANSHHAT-----EGDSRYMAPEILQ- 272
            |..|:|:            |.::....::||||...:|...|...|     .|.|.:.|||:|:
Yeast   799 KPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGTSGWRAPELLEE 863

  Fly   273 -------------------------------GHFSKAADIFSLGIAMLELACYMDLPSNGPLWHE 306
                                           ...:::.||||:|.....:......|.......|
Yeast   864 SNNLQCQVETEHSSSRHTVVSSDSFYDPFTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRE 928

  Fly   307 --LRHGILPEEFI-----NKISLELQSVIKSMMKPDPAQRPTAEQLLSHP-------KLQYLQK 356
              :..||...:.:     ..:..|...:|..|:..||.:||||.::|.||       ||::|.|
Yeast   929 SNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLEFLLK 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myt1	NP_647987.2	PKc_Myt1	100..349	CDD:270952	73/326 (22%)
Myt1	NP_647987.2	Pkinase	102..349	CDD:278497	72/324 (22%)
IRE1	NP_011946.1	Luminal_IRE1	120..407	CDD:188875
		STKc_IRE1	672..981	CDD:270884	74/325 (23%)
		RNase_Ire1	984..1113	CDD:199217	4/9 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910