DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myt1 and Rps6kb2

DIOPT Version :9

Sequence 1:	NP_647987.2	Gene:	Myt1 / 38649	FlyBaseID:	FBgn0040298	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_067460.1	Gene:	Rps6kb2 / 58988	MGIID:	1927343	Length:	485	Species:	Mus musculus

Alignment Length:	442	Identity:	105/442 - (23%)
Similarity:	168/442 - (38%)	Gaps:	126/442 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 SLSHFEQ------------------CFERLAKLGEGSFGEVFQVR---DRSDGQLYAVKI---SK 134
            ::.|:|:                  |||.|:.||:|.:|:|||||   ..:.|::||:|:   :|
Mouse    41 TVGHYEEVELTESSVNLGPERIGPHCFELLSVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAK 105

  Fly   135 QLFRGE---QYRAER--LEEVRRYEEFSGHENCIRFIRAWEQYDRLYMQME-LCRESLEQYLLRC 193
            .:...:   ..||||  ||.|:       |...:....|::...:||:.:| |....|..:|.|.
Mouse   106 IVCSAKDTAHTRAERNILESVK-------HPFIVELAYAFQTGGKLYLILECLSGGELFTHLERE 163

  Fly   194 QRIPEERIWHILLDLLRGLKSLHDRNLIHLDIKLDNVLIGEDDETCKLADFGLVID-VDRANSHH 257
            ....|:.....|.::...|..||...:|:.|:|.:|:::..... .||.||||..: :......|
Mouse   164 GIFLEDTACFYLAEITLALGHLHSHGIIYRDLKPENIMLSSQGH-IKLTDFGLCKESIHEGAITH 227

  Fly   258 ATEGDSRYMAPEIL--QGHFSKAADIFSLGIAMLELACYMDLPSNGPLWHELRHGILPEEFINKI 320
            ...|...|||||||  .|| ::|.|.:|||..|.::     |..:.|...|.|...:.:....|:
Mouse   228 TFCGTIEYMAPEILVRTGH-NRAVDWWSLGALMYDM-----LTGSPPFTAENRKKTMDKIIKGKL 286

  Fly   321 SL------ELQSVIKSMMKPDPAQR-----PTAEQLLSHPKLQYLQKKRKSLMNFSMLSRSFRRS 374
            .|      :.:.:.|..:|.:|.||     ..|..:..||..:::
Mouse   287 VLPPYLTPDARDLAKKFLKRNPTQRIGGGLGDAADVQRHPFFRHI-------------------- 331

  Fly   375 RRAVWGRMCNWKTAAFRYLLYFLEVLHLCKPITASQPNINIVPSSPSSKGVPLVPQVEFQLVGST 439
                     ||.....|.:                .|     |..||.:....|.|.:.:....|
Mouse   332 ---------NWDDLLARRV----------------DP-----PFRPSLQSEEDVSQFDARFTRQT 366

  Fly   440 PIANRDCYA------SDFLS----GEDPLDLSNQG--------SPNVINSTP 473
            |:.:.|..|      ..||.    ....||...:|        ||..:||:|
Mouse   367 PVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSP 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myt1	NP_647987.2	PKc_Myt1	100..349	CDD:270952	78/292 (27%)
Myt1	NP_647987.2	Pkinase	102..349	CDD:278497	77/272 (28%)
Rps6kb2	NP_067460.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		S_TKc	67..328	CDD:214567	79/274 (29%)
		STKc_p70S6K	70..392	CDD:270736	92/385 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..485		5/12 (42%)
		Nuclear localization signal. /evidence=ECO:0000250	474..480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910