DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myt1 and Ire1

DIOPT Version :9

Sequence 1:	NP_647987.2	Gene:	Myt1 / 38649	FlyBaseID:	FBgn0040298	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001097839.1	Gene:	Ire1 / 42358	FlyBaseID:	FBgn0261984	Length:	1074	Species:	Drosophila melanogaster

Alignment Length:	579	Identity:	137/579 - (23%)
Similarity:	207/579 - (35%)	Gaps:	164/579 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 RHKQCNGENSNRFRPPKYKTRGYVAVDNNNLNRSQSLGSCSTNSSQIAHAISFRDAGCSDSSTLP 82
            |..|...||.:       ||   .|:..|..|     ||..:|.|. |:|....|.|..
  Fly   497 RELQKQSENGS-------KT---FAIAQNGSN-----GSTGSNGSN-ANAEDLVDLGNG------ 539

  Fly    83 SSPVQAELSTLSLSHFEQCFERLAKLGEGSFGEVFQVRDRSDGQLYAVK-ISKQLFRGEQYRAER 146
                |..:..:|.|..|       .||:|..| .|..:...:.:..||| :..:.|.    .|:|
  Fly   540 ----QVRVGKISFSTNE-------VLGKGCEG-TFVFKGTFEERFVAVKRLLPECFT----FADR 588

  Fly   147 LEEVRRYEEFSGHENCIRFIRAWEQYDRLYMQMELCRESLEQYL-----LRCQRIPEERIWHILL 206
              ||....|...|||.:|:....:.....|:.:|||..:|:.|.     |..|...:  :|.:|.
  Fly   589 --EVALLRESDAHENVVRYFCTEQDRQFRYIAVELCAATLQDYTEGDRSLELQNHID--VWQVLS 649

  Fly   207 DLLRGLKSLHDRNLIHLDIKLDNVLIGEDDETCK----LADFGLV-------IDVDRANSHHATE 260
            ....||..||..:::|.|||..||||...|...|    ::||||.       ....|.:....|:
  Fly   650 QAASGLSHLHSLDIVHRDIKPQNVLISLPDAKGKVRVMISDFGLCKKLNFGKTSFSRRSGVTGTD 714

  Fly   261 GDSRYMAPEILQG-HFSKAADIFSLGIAMLELACYMDLPSNGP-------------LWHELRHGI 311
            |   ::|||:::. ..:.|.||||||      ..|..:.|.|.             |.||.....
  Fly   715 G---WIAPEMMRSQRTTTAVDIFSLG------CVYYYVLSGGHHAFGDNLKRQANILSHEYNLAK 770

  Fly   312 L-PEEFINKISLEL-QSVIKSMMKPDPAQRPTAEQLLSHP--------------------KLQYL 354
            | ||:......:.| :.:|..|:..||..||.|..:.:||                    |||:.
  Fly   771 LRPEDDSEDSRIILAEQLISDMIHKDPQSRPPARCIGNHPLFWDEPKMLSFLQDVSDRVEKLQFH 835

  Fly   355 QKKRKSLMNFS--------------MLSRSFRRSRRAVWGRMCNWKTAAFRYLLYFL--EVLHLC 403
            .:..|||....              |::...|:.|        .:..|:.|.||..|  :..|..
  Fly   836 AEPLKSLEKNGRIVVLDDWNVHLDPMITDDLRKYR--------GYMGASVRDLLRALRNKKHHYH 892

  Fly   404 KPITASQPNINIVPSSPSSKGVPLVPQV------EFQLVGSTPIANRDCYASDFLSGE------- 455
            :...|:|..:..:|...::..|...||:      .|.:..:.||. :..|::.:|...
  Fly   893 ELTPAAQKMLGCIPHEFTNYWVDRFPQLISHAYHAFSICSNEPIF-KPYYSAGYLFTRPWYFDAD 956

  Fly   456 ---------DPLDLSNQGSPNVINSTPLNTNQGKSRLDLLKNNVDSMGRYVHVHDFESP 505
                     ||..|...|||   ..||...:....:|...|.          :::|..|
  Fly   957 DALFPMLMLDPKPLPKIGSP---KKTPSPASSQAQQLKQRKG----------LYNFRKP 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myt1	NP_647987.2	PKc_Myt1	100..349	CDD:270952	76/281 (27%)
Myt1	NP_647987.2	Pkinase	102..349	CDD:278497	76/279 (27%)
Ire1	NP_001097839.1	Luminal_IRE1	53..321	CDD:188875
		STKc_IRE1	545..813	CDD:270884	81/292 (28%)
		S_TKc	552..812	CDD:214567	79/284 (28%)
		RNase_Ire1	817..941	CDD:199217	24/132 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910