DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myt1 and Strn-Mlck

DIOPT Version :9

Sequence 1:	NP_647987.2	Gene:	Myt1 / 38649	FlyBaseID:	FBgn0040298	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001261019.1	Gene:	Strn-Mlck / 36753	FlyBaseID:	FBgn0265045	Length:	8255	Species:	Drosophila melanogaster

Alignment Length:	587	Identity:	129/587 - (21%)
Similarity:	215/587 - (36%)	Gaps:	155/587 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KQCNGENSNRFRPPKYKTRGYVAVDNNNLNRSQSLGSCS-----TNSSQIAHAISFRDAGCSDSS 79
            |....|...|||           |...|::...:.|..|     ||:.|           .|.||
  Fly  7555 KNLQPERQYRFR-----------VRAENIHGRSAPGQASELVQITNTPQ-----------RSTSS 7597

  Fly    80 TLPSSPVQAELSTLSLSHFEQCFERLAKLGEGSFGEVFQVRDRSD-GQLYAVKISKQLFRGEQYR 143
            .......||.:|..|...|:..||.:.:||:|.||.|::|::|.. .||.|.|:.|.:  ..|.|
  Fly  7598 DASDRFGQATVSVQSGGDFKSRFEIIEELGKGRFGIVYKVQERGQPEQLLAAKVIKCI--KSQDR 7660

  Fly   144 AERLEEVRRYEEFSGHENCIRFIRAWEQYDRLYMQMELCR--ESLEQYLLRCQRIPEERIWHILL 206
            .:.|||:....... |...::...::|....:.|.||...  |..|:.:.....:.|......|.
  Fly  7661 QKVLEEISIMRALQ-HPKLLQLAASFESPREIVMVMEYITGGELFERVVADDFTLTEMDCILFLR 7724

  Fly   207 DLLRGLKSLHDRNLIHLDIKLDNVLI-GEDDETCKLADFGLVIDVDRANSHHATEGDSRYMAPEI 270
            .:..|:..:|.::::|||:|.:|::. .......|:.||||...:|.........|...::.|||
  Fly  7725 QVCDGVAYMHGQSVVHLDLKPENIMCHTRTSHQIKIIDFGLAQRLDTKAPVRVLFGTPEFIPPEI 7789

  Fly   271 LQGH-FSKAADIFSLGIAMLELACYMDLPSNGPLWHELRHGILP--------------------- 313
            :... ....:|::|:|:     .||:           |..|:.|
  Fly  7790 ISYEPIGFQSDMWSVGV-----ICYV-----------LLSGLSPFMGDTDVETFSNITRADYDYD 7838

  Fly   314 EEFINKISLELQSVIKSMMKPDPAQRPTAEQLLSHPKLQYLQKKRKSLMNFS---------MLSR 369
            :|..:.:|.|.:..|..::......|.||:|.|:...|.  |:...||.|..         ::.|
  Fly  7839 DEAFDCVSQEAKDFISQLLVHRKEDRLTAQQCLASKWLS--QRPDDSLSNNKICTDKLKKFIIRR 7901

  Fly   370 SFRRSRRAV--WGRMCNWKTAAFRYLLYFLEVLHLCKPITASQPNINI---VPSS--PSSKGVPL 427
            .::::..|:  .|||.|                     ::.|:.|..|   |.||  ||..|:.:
  Fly  7902 KWQKTGNAIRALGRMAN---------------------LSVSRRNSAIAMGVLSSPRPSISGLGM 7945

  Fly   428 VPQVEFQLVGS------TPIANRDCYASDFLSGEDP----------------LDLSNQGSPNVIN 470
            :..   ..:||      |.:...:    |..|||.|                .:.|:.|.....|
  Fly  7946 LTT---SAIGSGTSSQMTSLHEEE----DDFSGEMPPVEKRTVLKLRDKSQCSERSDSGYSECSN 8003

  Fly   471 STPLNTNQGKSRLDLLKNNVDSMGRY----VHVHDFESPCS--------ALSSAKVLDTSSFRRK 523
            .:..   |....|.|.|:.::::.:.    ..|||.|.|.|        |:..:...:|...|:|
  Fly  8004 CSGA---QETLLLSLAKSKLEAIAKASTLPTVVHDTEQPVSLELPTKGEAIMRSDFTNTIKMRKK 8065

  Fly   524 KL 525
            .|
  Fly  8066 SL 8067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myt1	NP_647987.2	PKc_Myt1	100..349	CDD:270952	63/274 (23%)
Myt1	NP_647987.2	Pkinase	102..349	CDD:278497	63/272 (23%)
Strn-Mlck	NP_001261019.1	IG_like	51..127	CDD:214653
		Ig	<69..>112	CDD:299845
		I-set	137..226	CDD:254352
		I-set	235..314	CDD:254352
		Ig_2	244..314	CDD:290606
		I-set	438..513	CDD:254352
		Ig	454..510	CDD:143165
		I-set	537..626	CDD:254352
		Ig	555..618	CDD:299845
		I-set	636..713	CDD:254352
		Ig	652..712	CDD:143165
		SMC_N	<2190..2854	CDD:280601
		I-set	5300..5388	CDD:254352
		IGc2	5313..5378	CDD:197706
		IG	5412..5482	CDD:214652
		IGc2	5413..5481	CDD:197706
		I-set	5542..5627	CDD:254352
		Ig	5556..5621	CDD:143165
		Ig	5654..5721	CDD:143165
		I-set	5784..5874	CDD:254352
		IGc2	5797..5864	CDD:197706
		I-set	5887..5970	CDD:254352
		Ig	5902..5966	CDD:143165
		I-set	5997..6086	CDD:254352
		Ig	6026..6083	CDD:143165
		I-set	6097..6187	CDD:254352
		Ig	6114..6187	CDD:299845
		FN3	6216..6310	CDD:238020
		I-set	6321..6412	CDD:254352
		Ig	6328..6412	CDD:299845
		I-set	6442..6531	CDD:254352
		Ig	6459..6528	CDD:143165
		I-set	6541..6632	CDD:254352
		IGc2	6555..6622	CDD:197706
		I-set	6662..6754	CDD:254352
		Ig	6679..6751	CDD:143165
		I-set	6779..6868	CDD:254352
		IGc2	6793..6858	CDD:197706
		Ig	6938..7022	CDD:299845
		I-set	6939..7028	CDD:254352
		IG	7075..7140	CDD:214652
		Ig	7075..7140	CDD:143165
		IG	7167..7239	CDD:214652
		Ig	7173..7239	CDD:143165
		Ig	7392..7475	CDD:299845
		IG	7406..7475	CDD:214652
		FN3	7489..7588	CDD:238020	9/43 (21%)
		S_TKc	7620..7876	CDD:214567	63/274 (23%)
		STKc_MLCK	7626..7876	CDD:271005	61/268 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910