DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myt1 and Ern2

DIOPT Version :9

Sequence 1:	NP_647987.2	Gene:	Myt1 / 38649	FlyBaseID:	FBgn0040298	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001102389.1	Gene:	Ern2 / 365363	RGDID:	1308743	Length:	927	Species:	Rattus norvegicus

Alignment Length:	314	Identity:	87/314 - (27%)
Similarity:	141/314 - (44%)	Gaps:	59/314 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 PSSPVQ------AELSTL--SLSHFEQCFERLAKLGEGSFGEVFQVRDRSDGQLYAVK-ISKQLF 137
            |..|||      ||..|:  .:|     |.....||.|: |..|..|.:.:|:..||| :.::.|
  Rat   487 PPEPVQPAHDPEAEQPTVVGKIS-----FNPKDVLGRGA-GGTFVFRGQFEGRAVAVKRLLRECF 545

  Fly   138 RGEQYRAERLEEVRRYEEFSGHENCIRFIRAWEQYDRLYMQMELCRESLEQYLLRCQRIPEERIW 202
            ...|      .||:..:|...|.|.:|:....:.....|:.:|||:.||::|:    ..|:...|
  Rat   546 SLVQ------REVQLLQESDRHPNVLRYFCTEQGPQFHYIALELCQASLQEYV----ESPDLDRW 600

  Fly   203 -----HILLDLLRGLKSLHDRNLIHLDIKLDNVLIGEDDETCK----LADFGLV--IDVDRA--N 254
                 .:|..::.||..||..:::|.|:|..|:|:...|...:    ::||||.  :...|.  :
  Rat   601 GLGPTMVLQQMMSGLAHLHSLHIVHRDLKPGNILMAGPDSQGQGRVVISDFGLCKKLPAGRCSFS 665

  Fly   255 SHHATEGDSRYMAPEILQ---GHFSKAADIFSLGIAMLELACYMDLPSNGPLWHELR-----HGI 311
            .|....|...:||||:||   ...:.|.||||.|.....:......|....|:.:..     |.:
  Rat   666 LHSGIPGTEGWMAPELLQLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGESLYRQANILSGDHCL 730

  Fly   312 --LPEEFINK-ISLELQSVIKSMMKPDPAQRPTAEQLLSHP-------KLQYLQ 355
              |.||..:| ::|:|   :|:|:...|..||:|..:|:||       :||:.|
  Rat   731 AQLQEETHDKVVALDL---VKAMLSLLPQDRPSAGWVLAHPLFWSRAKELQFFQ 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myt1	NP_647987.2	PKc_Myt1	100..349	CDD:270952	74/273 (27%)
Myt1	NP_647987.2	Pkinase	102..349	CDD:278497	74/271 (27%)
Ern2	NP_001102389.1	Luminal_IRE1	37..365	CDD:188875
		PQQ	<40..236	CDD:224437
		STKc_IRE1	507..771	CDD:270884	77/282 (27%)
		S_TKc	510..770	CDD:214567	76/273 (28%)
		RNase_Ire1	774..899	CDD:199217	3/8 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910