DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myt1 and plk3

DIOPT Version :9

Sequence 1:	NP_647987.2	Gene:	Myt1 / 38649	FlyBaseID:	FBgn0040298	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_958465.1	Gene:	plk3 / 334202	ZFINID:	ZDB-GENE-030131-6134	Length:	644	Species:	Danio rerio

Alignment Length:	556	Identity:	118/556 - (21%)
Similarity:	216/556 - (38%)	Gaps:	169/556 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 PSSPVQAELSTLSLSHFE---------------QCFERLAKLGEGSFGEVFQVRDRSDGQLYAVK 131
            |::|..|:.|.....|.:               .|..:|  ||:|.|...:::.|.::.::||||
Zfish    10 PAAPPPAKPSRSKSEHVKPELAQVVVDAKTGRSYCKGKL--LGKGGFARCYEMTDLANNKMYAVK 72

  Fly   132 ISKQLFRGEQYRAER-LEEVRRYEEFSGHENCIRFIRAWEQYDRLYMQMELC-RESLEQYLLRCQ 194
            :..|....:.::.|: :.|:..::... |::.::|...:|..|.:|:.:||| |:||........
Zfish    73 VIPQSRVSKPHQREKIINEIELHKSLQ-HKHVVKFSHHFEDQDNIYIFLELCSRKSLAHIWKARH 136

  Fly   195 RIPEERIWHILLDLLRGLKSLHDRNLIHLDIKLDNVLIGEDDETCKLADFGLVIDVDRANSHHAT 259
            .:.:..:.:.|..::..||.||::.::|.|:||.|..:.|:.| .:|.||||...::.......|
Zfish   137 TLTDPEVRYYLRQIISSLKYLHNKGILHRDLKLGNFFVNENME-LRLGDFGLAAKLETVEQRKKT 200

  Fly   260 E-GDSRYMAPEIL--QGHFSKAADIFSLGIAMLELAC------YMDLPSNGPLWHELRHGILPEE 315
            . |...|:|||:|  |||.:: :|::|||..|..|.|      .:||........|:::. ||
Zfish   201 ICGTPNYLAPEVLNRQGHGTE-SDVWSLGCVMYTLLCGNPPFETLDLKETYKCIKEVKYS-LP-- 261

  Fly   316 FINKISLELQSVIKSMMKPDPAQRPTAEQLLSH---------------------------PKLQY 353
              :.::...|.:|.|:::.:|..|.|.:|:|:|                           |..::
Zfish   262 --SSLTPSAQKLISSILQKNPCDRLTLDQILAHDYFTKGFTPEKLPPSSCVMVPELNPPSPAKKF 324

  Fly   354 LQKKRKSLMNFSMLSRSFRRS----------------RRAVWGRMCNWKTAAFRYLLYFLEVLHL 402
            ..|..|||.. ...|::..::                :.:: ||..::||....
Zfish   325 FTKMAKSLFG-KKKSKTVEKTTSEEKDDISKLVSGMVKHSI-GRQMSYKTMGVN----------- 376

  Fly   403 CKPITASQPNINIVPSSP-----------------------SSKGVPLVP----------QVEFQ 434
                .|:.|.:.:..|.|                       |:.|...:|          :|...
Zfish   377 ----EATSPTVQLASSGPLDTPAEEESRKSASRSFKGTVASSTDGCDDIPTPSAVAESAMKVLNS 437

  Fly   435 LVGSTPIANRD--C---------------YASDF-----LSGEDPLDLSNQG------------- 464
            .:.|.|.|:|:  |               |::.:     ||.::...|.|:|
Zfish   438 CLSSMPTASRNPPCLVKTKPFIWVTKWVDYSNKYGFGYQLSNQNVGVLFNEGTHLSLCDQRRTVH 502

  Fly   465 ---SPNVINSTPLNTNQGKSRLDLLKNNVDSMGRYV 497
               :.|...|.|.|....|  |...|:.||.|..|:
Zfish   503 YCLTNNKHFSFPANALPEK--LQSQKHIVDLMANYM 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myt1	NP_647987.2	PKc_Myt1	100..349	CDD:270952	73/286 (26%)
Myt1	NP_647987.2	Pkinase	102..349	CDD:278497	72/284 (25%)
plk3	NP_958465.1	STKc_PLK3	41..295	CDD:271091	73/263 (28%)
		S_TKc	43..295	CDD:214567	73/261 (28%)
		POLO_box_1	457..545	CDD:240561	17/82 (21%)
		POLO_box_2	557..640	CDD:240560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910