DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myt1 and AgaP_AGAP001950

DIOPT Version :9

Sequence 1:	NP_647987.2	Gene:	Myt1 / 38649	FlyBaseID:	FBgn0040298	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_550868.4	Gene:	AgaP_AGAP001950 / 3290534	VectorBaseID:	AGAP001950	Length:	578	Species:	Anopheles gambiae

Alignment Length:	542	Identity:	234/542 - (43%)
Similarity:	303/542 - (55%)	Gaps:	117/542 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LPLPELHDD---KHRHKQCNG--ENSNRFRPPKYKTRGYVAVDNNNLNRSQSLGSCSTNSSQIAH 66
            ||||||.::   ....|:..|  :..:|.||||..         ..|||       |.|:| :|:
Mosquito     5 LPLPELFEEDEFSFSFKKPRGLHDAFSRRRPPKLM---------QPLNR-------SINAS-MAN 52

  Fly    67 AISFRDAGCSDSSTLPSSPVQAELSTLSLSH-----FEQCFERLAKLGEGSFGEVFQVRDRSDGQ 126
            .||||   ..||        :||||.|...|     :|||||:|.|:|||||||||:||.|:||:
Mosquito    53 VISFR---LDDS--------RAELSALYNRHKPETYYEQCFEQLTKVGEGSFGEVFKVRSRTDGR 106

  Fly   127 LYAVKISKQLFRGEQYRAERLEEVRRYEEFSGHENCIRFIRAWEQYDRLYMQMELCRESLEQYLL 191
            |||||.||..||..|.|...||||||||:||.||||::..:||||.||||||||||||:||.|..
Mosquito   107 LYAVKKSKTYFRSSQCRQLCLEEVRRYEQFSDHENCVKLYQAWEQDDRLYMQMELCRENLEVYAR 171

  Fly   192 RCQRIPEERIWHILLDLLRGLKSLHDRNLIHLDIKLDNVLIGEDDETCKLADFGLVIDVDRANSH 256
            ..|::|:||||.||||||..||||||||||||||||||:|: .||.||||||||:|.|:.::|..
Mosquito   172 EQQQLPDERIWSILLDLLLALKSLHDRNLIHLDIKLDNILV-TDDGTCKLADFGIVFDLTKSNPR 235

  Fly   257 HATEGDSRYMAPEILQGHFSKAADIFSLGIAMLELACYMDLPSNGPLWHELRHG-ILPEEFINKI 320
            :||||||||||||:::|.::|||||||||||.|||||.::||.||.:|..||:| .|||....|:
Mosquito   236 YATEGDSRYMAPELMEGTYTKAADIFSLGIATLELACNLELPPNGRMWQRLRNGQPLPELLARKV 300

  Fly   321 SLELQSVIKSMMKPDPAQRPTAEQLLSHPKLQYLQKKRKSLMNFSMLSRSFRRSRRAVWGR---- 381
            |..|:.:|.|||:|.|.:|||.:.||.||.||.|.:.|:               ||.::.|
Mosquito   301 SPALKDIIHSMMRPVPTERPTVDVLLKHPMLQKLYEARR---------------RRRIFERTGSY 350

  Fly   382 MCNWKTAAFRYLLYFLEVLHLCKPI---------------------TASQPN-INIVPSSPSSKG 424
            :|...::..|::|..:..|..|..:                     ||...| .|:...|.|..|
Mosquito   351 LCRKLSSLARFVLVAVMWLVACFRLQHRKDSPDAKVERGQQKAANKTARSCNGSNLSVGSCSRTG 415

  Fly   425 VPLVPQVEFQLVGSTPIANRD--------------CYAS----DFLSG--------EDPLDLS-- 461
            :.......||...|:.:|:.|              |.|:    |..:|        :|.:.::
Mosquito   416 IAFGASRSFQEHCSSLLADDDNEMDFSGTGFDSSACTAAGDDCDRTAGTQDGGGTDKDSVQITPT 480

  Fly   462 -NQGSP-------NVINSTPLN 475
             |...|       .::||||||
Mosquito   481 LNNSMPPTRTPTVRIVNSTPLN 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myt1	NP_647987.2	PKc_Myt1	100..349	CDD:270952	162/249 (65%)
Myt1	NP_647987.2	Pkinase	102..349	CDD:278497	160/247 (65%)
AgaP_AGAP001950	XP_550868.4	PKc_like	80..329	CDD:304357	162/249 (65%)
AgaP_AGAP001950	XP_550868.4	S_TKc	82..331	CDD:214567	162/249 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	328	1.000	Domainoid score	I3177
eggNOG	1	0.900	-	-		E1_KOG0601
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	352	1.000	Inparanoid score	I4486
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063695at2759
OrthoFinder	1	1.000	-	-		FOG0003337
OrthoInspector	1	1.000	-	-		oto108532
Panther	1	1.100	-	-	LDO	PTHR11042
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4326
TreeFam	1	0.960	-	-
	11	10.930