DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myt1 and Nek8

DIOPT Version :9

Sequence 1:	NP_647987.2	Gene:	Myt1 / 38649	FlyBaseID:	FBgn0040298	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001099274.1	Gene:	Nek8 / 287473	RGDID:	1306897	Length:	698	Species:	Rattus norvegicus

Alignment Length:	260	Identity:	65/260 - (25%)
Similarity:	129/260 - (49%)	Gaps:	19/260 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 FERLAKLGEGSFGEVFQVRDRSDGQLYAVK--ISKQLFRGEQYRAERLEEVRRYEEFSGHENCIR 164
            :||:..:|.|:||.|.....::|.:|..:|  ..:|:.:.|:..|:...:|.:   ...|.|.|.
  Rat     4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLK---LLNHPNVIE 65

  Fly   165 FIRAWEQYDRLYMQMELC-RESLEQYL-LRCQR-IPEERIWHILLDLLRGLKSLHDRNLIHLDIK 226
            :...:.:...|.:.||.. ..:|.::: .||.. :.||.|.|..:.:|..|..:|...::|.|:|
  Rat    66 YYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLK 130

  Fly   227 LDNVLIGEDDETCKLADFGLVIDVDRANSHHATEGDSRYMAPEILQGH-FSKAADIFSLGIAMLE 290
            ..|:|:.:.....|:.|||:...:...:..:...|...|::||:.:|. :::.:||::||..:.|
  Rat   131 TQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYE 195

  Fly   291 LACY------MDLPSNGPLWHELRHGILPEEFINKISLELQSVIKSMMKPDPAQRPTAEQLLSHP 349
            ||..      .:||:   |..::..|.. ....::.|.||:.::.|::..:|||||....:::.|
  Rat   196 LASLKRAFEAANLPA---LVLKIMSGTF-APISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQP 256

Fly 350 349
Rat 257 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myt1	NP_647987.2	PKc_Myt1	100..349	CDD:270952	64/258 (25%)
Myt1	NP_647987.2	Pkinase	102..349	CDD:278497	64/258 (25%)
Nek8	NP_001099274.1	STKc_Nek8	3..258	CDD:270859	65/260 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..307
		ATS1	318..663	CDD:227511
		RCC1 1	415..466
		RCC1 2	467..518
		RCC1 3	520..571
		RCC1 4	585..636
		RCC1 5	638..689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910