DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myt1 and Pkmyt1

DIOPT Version :9

Sequence 1:	NP_647987.2	Gene:	Myt1 / 38649	FlyBaseID:	FBgn0040298	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001099236.1	Gene:	Pkmyt1 / 287101	RGDID:	1305434	Length:	490	Species:	Rattus norvegicus

Alignment Length:	496	Identity:	177/496 - (35%)
Similarity:	259/496 - (52%)	Gaps:	78/496 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRFRPPKYKTRGYVAVDNNNLNRSQSLGSCSTNSSQIAHAISFRDAGCSDSSTLPS---SPVQAE 89
            :|..||:...:|.:.|  :.|...::.|.......:::..       |..|.||.|   .|.:.|
  Rat    39 SRSLPPRPPAKGSIPV--SRLFPPRTPGWQQPQPRRVSFL-------CETSETLQSPGYDPSRPE 94

  Fly    90 LSTLSLSHFEQCFERLAKLGEGSFGEVFQVRDRSDGQLYAVKISKQLFRGEQYRAERLEEVRRYE 154
                  |.|:|.|:||::||.||:||||:||.:.||:|||||.|...|||.:.|..:|.||..:|
  Rat    95 ------SFFQQNFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRTRKLAEVGGHE 153

  Fly   155 EFSGHENCIRFIRAWEQYDRLYMQMELCRESLEQYLLRCQ----RIPEERIWHILLDLLRGLKSL 215
            :...|.:|:|..||||:...||:|.|||..||:|:   |:    .:||.::|..|.|.|..|..|
  Rat   154 KVGQHPHCVRLERAWEEGGILYLQTELCGPSLQQH---CEAWGASLPEAQVWGYLRDTLLALDHL 215

  Fly   216 HDRNLIHLDIKLDNVLIGEDDETCKLADFGLVIDVDRANSHHATEGDSRYMAPEILQGHFSKAAD 280
            |.:.|:|||:|..|:.:|.... |||.||||::::..|.:..|.|||.||||||:|:|.:..|||
  Rat   216 HSQGLVHLDVKPANIFLGPRGR-CKLGDFGLLVELGSAGAGEAQEGDPRYMAPELLRGSYGTAAD 279

  Fly   281 IFSLGIAMLELACYMDLPSNGPLWHELRHGILPEEFINKISLELQSVIKSMMKPDPAQRPTAEQL 345
            :||||:.:||:||.|:||..|..|.:||.|.||.||...:|.||:||:..|::|||..|.|||.|
  Rat   280 VFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLTMMLEPDPQLRATAEVL 344

  Fly   346 LSHPKLQYLQKKRKSL---MNFSMLSRSFRRSRRAVWGRMCNWKTAAFRYLLYFL--EVLHLCK- 404
            |:.|.|:  |.:..::   |....|||.:     |:|        .|...||.:|  .::|...
  Rat   345 LALPMLR--QPRPWNVLWYMAAEALSRGW-----ALW--------QALVTLLCWLWHGLVHPASW 394

  Fly   405 ------PIT--ASQPNINIVPSSPSSK------GVPLVPQVEFQLV---GSTPIANRDCYASDFL 452
                  |.|  .|.|...::.|:.||.      |..|.|:.....:   .|||   |..|
  Rat   395 LQPPGPPATPPGSPPCSPLLDSTLSSNWDDDSIGPSLSPETILSRITRRTSTP---RGRY----- 451

  Fly   453 SGEDPLDLSNQGS--PNVINSTPLNTNQGKSRLDLLKNNVD 491
            :..|.|||::..|  |.    .|..|.:.::.|.|.::::|
  Rat   452 TPRDVLDLTDMDSEPPR----GPCPTFEPRNLLSLFEDSLD 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myt1	NP_647987.2	PKc_Myt1	100..349	CDD:270952	121/252 (48%)
Myt1	NP_647987.2	Pkinase	102..349	CDD:278497	120/250 (48%)
Pkmyt1	NP_001099236.1	PKc_Myt1	99..348	CDD:270952	121/252 (48%)
Pkmyt1	NP_001099236.1	S_TKc	101..350	CDD:214567	121/252 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354083
Domainoid	1	1.000	238	1.000	Domainoid score	I2233
eggNOG	1	0.900	-	-		E1_KOG0601
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	246	1.000	Inparanoid score	I3196
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063695at2759
OrthoFinder	1	1.000	-	-		FOG0003337
OrthoInspector	1	1.000	-	-		oto97105
orthoMCL	1	0.900	-	-		OOG6_104974
Panther	1	1.100	-	-	LDO	PTHR11042
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4326
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760