DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myt1 and Nek3

DIOPT Version :9

Sequence 1:	NP_647987.2	Gene:	Myt1 / 38649	FlyBaseID:	FBgn0040298	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001156419.1	Gene:	Nek3 / 23954	MGIID:	1344371	Length:	511	Species:	Mus musculus

Alignment Length:	467	Identity:	106/467 - (22%)
Similarity:	167/467 - (35%)	Gaps:	139/467 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 LAKLGEGSFGEVFQVRDRSDGQLYAVKISKQLFRGEQYRAERLEEVRRYEEFSGHENCIRFIRAW 169
            |..:|:||||....|...|..|.:|:|..:.|....|  ..|.|.|...:  ..|.|.:.|..::
Mouse     7 LRVIGQGSFGRALLVLQESSNQTFAMKEIRLLKSDTQ--TSRKEAVLLAK--MKHPNIVAFKESF 67

  Fly   170 EQYDRLYMQMELCRESLEQYLLRCQR---IPEERIWHILLDLLRGLKSLHDRNLIHLDIKLDNVL 231
            |....||:.||.|........::.|:   .||:.|.:..:.:..|:..:|.|.::|.|||..||.
Mouse    68 EAEGYLYIVMEYCDGGDLMQRIKQQKGKLFPEDTILNWFIQICLGVNHIHKRRVLHRDIKSKNVF 132

  Fly   232 IGEDDETCKLADFGLVIDVDRANSHHAT-EGDSRYMAPEILQG-HFSKAADIFSLGIAMLELACY 294
            :..:.:. ||.|||....:....:...| .|...|:.|||.:. .::..:||:|||..:.|| |.
Mouse   133 LTHNGKV-KLGDFGSARLLSSPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYEL-CA 195

  Fly   295 MDLPSNGPLWHELRHGI-------LPEEFINKISLELQSVIKSMMKPDPAQRPTAEQLLSHPKL- 351
            :..|.....|..|...|       ||..:    |.:||.::|.|:|.:|:.||:|..||....|
Mouse   196 LKHPFQANSWKNLILKICQGPIHPLPALY----SCKLQGLVKQMLKRNPSHRPSATTLLCRGSLA 256

  Fly   352 ---------QYLQKKRKSLMN-------FSMLSRSFRRSRRAVW------------GRMCNWKTA 388
                     |.:::..:.:::       .:|..:...|.|||:.            ||.|:
Mouse   257 PLVPKCLPPQIIREYGEQILDEIKISTPKNMKKQDSNRVRRALGEANSASMQEEERGRKCS---- 317

  Fly   389 AFRYLLYFLEVLHLCKPITASQPNINIVPSSPSSKGVPLVPQVEFQLVGSTPIANRDCYASDFLS 453
                                                     ..|.:..|:||..|
Mouse   318 -----------------------------------------HTELESTGTTPAGN---------- 331

  Fly   454 GEDPLDLSNQGSPNVINSTPLNTNQGKSRLDLLKNNVDSMGRYV----------HVHDFESPCSA 508
               .|:.:.:|:|.                   ..|....||:.          ..|...|...|
Mouse   332 ---ALERAARGNPE-------------------SGNPQEHGRHTSPASPHRPWWERHGPSSNVEA 374

  Fly   509 LSSAKVLDTSSF 520
            |..|.:| ||||
Mouse   375 LEKASIL-TSSF 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myt1	NP_647987.2	PKc_Myt1	100..349	CDD:270952	75/255 (29%)
Myt1	NP_647987.2	Pkinase	102..349	CDD:278497	75/255 (29%)
Nek3	NP_001156419.1	Interaction with VAV2. /evidence=ECO:0000250	1..282		77/284 (27%)
		PKc_like	3..255	CDD:389743	75/257 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	299..370		15/147 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..511
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910