DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myt1 and Mark4

DIOPT Version :9

Sequence 1:	NP_647987.2	Gene:	Myt1 / 38649	FlyBaseID:	FBgn0040298	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_758483.1	Gene:	Mark4 / 232944	MGIID:	1920955	Length:	752	Species:	Mus musculus

Alignment Length:	515	Identity:	117/515 - (22%)
Similarity:	198/515 - (38%)	Gaps:	108/515 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DNNNLNRSQSLGSCSTNSSQIAHAISFRDAGCSDSSTLPSSPVQAELSTLSLSHFEQCFERLAKL 108
            ::.|.:...:||  |..||....:.|.|..|....:::.|.|.:.       .|... :..|..:
Mouse    11 NDRNSDTHGTLG--SGRSSDKGPSWSSRSLGARCRNSIASCPEEQ-------PHVGN-YRLLRTI 65

  Fly   109 GEGSFGEVFQVRDRSDGQLYAVKI----------SKQLFRGEQYRAERLEEVRRYEEFSGHENCI 163
            |:|:|.:|...|....|:..|:||          .::|||          |||..:..: |.|.:
Mouse    66 GKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFR----------EVRIMKGLN-HPNIV 119

  Fly   164 RFIRAWEQYDRLYMQMELCRE-SLEQYLLRCQRIPEERIWHILLDLLRGLKSLHDRNLIHLDIKL 227
            :.....|....||:.||.... .:..||:...|:.|:........::..:...|.:|::|.|:|.
Mouse   120 KLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKA 184

  Fly   228 DNVLIGEDDETCKLADFGLVIDVDRANSHHATEGDSRYMAPEILQG--HFSKAADIFSLGIAMLE 290
            :|:|: :.:...|:||||...:....:......|...|.|||:.||  :.....||:|||:.:..
Mouse   185 ENLLL-DAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYT 248

  Fly   291 LACYMDLPSNGPLWHELRHGILPEEFINK--ISLELQSVIKSMMKPDPAQRPTAEQLL------- 346
            |.. ..||.:|....|||..:|..::...  :|.:.:|:::..:..:||:|.|.||::
Mouse   249 LVS-GSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINI 312

  Fly   347 ----------SHPKLQYLQKKRKSLMNFSMLSRSFRRS--RRAVWGRMCNWKTAAFRYLLYFLEV 399
                      :.|:..:...||..:    |:...:.|.  :.|:..:..|..||.  |||...:.
Mouse   313 GYEGEELKPYTEPEEDFGDTKRIEV----MVGMGYTREEIKEALTNQKYNEVTAT--YLLLGRKT 371

  Fly   400 ----------LHLCKPITASQPNINIVPSSPSS---KGVPLVPQVEFQLVGSTPIANRDCYASDF 451
                      |.|.: :.|.....|...||..|   ||..          .|:...:|....|||
Mouse   372 EEGGDRGAPGLALAR-VRAPSDTTNGTSSSKGSSHNKGQR----------ASSSTYHRQRRHSDF 425

  Fly   452 LSGEDPLDLSNQGSPNVINSTPLNTNQGKSRLDLLKNNVDSMGRYVHVHDFESPCSALSS 511
             .|..|..|..:.||.....|.|...:...|                    ::.|||:.|
Mouse   426 -CGPSPAPLHPKRSPTSTGDTELKEERMPGR--------------------KASCSAVGS 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myt1	NP_647987.2	PKc_Myt1	100..349	CDD:270952	67/280 (24%)
Myt1	NP_647987.2	Pkinase	102..349	CDD:278497	67/278 (24%)
Mark4	NP_758483.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		7/26 (27%)
		STKc_MARK	58..310	CDD:270974	67/265 (25%)
		S_TKc	59..310	CDD:214567	67/263 (25%)
		UBA_MARK3_4	328..370	CDD:270590	11/47 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..615		24/112 (21%)
		MARK4_C	654..752	CDD:213382
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910