DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myt1 and Wee1

DIOPT Version :9

Sequence 1:	NP_647987.2	Gene:	Myt1 / 38649	FlyBaseID:	FBgn0040298	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_033542.2	Gene:	Wee1 / 22390	MGIID:	103075	Length:	646	Species:	Mus musculus

Alignment Length:	335	Identity:	101/335 - (30%)
Similarity:	161/335 - (48%)	Gaps:	34/335 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 SFRDAGCSD----SSTLPSSPVQAELSTLSLSHFEQCFERLAKLGEGSFGEVFQVRDRSDGQLYA 129
            |..|...||    ..|.|:..:....|.:. |.:...|..|.|:|.|.||.||:...|.||.:||
Mouse   262 SSEDMEASDYEFEDETRPAKRITITESNMK-SRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYA 325

  Fly   130 VKISKQLFRGEQYRAERLEEVRRYEEFSGHENCIRFIRAWEQYDRLYMQMELCR-----ESLEQY 189
            :|.||:...|.......|.||..:.....|.:.:|:..||.:.|.:.:|.|.|.     :::.:.
Mouse   326 IKRSKKPLAGSVDEQNALREVYAHAVLGQHPHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISEN 390

  Fly   190 LLRCQRIPEERIWHILLDLLRGLKSLHDRNLIHLDIKLDNVLI------------GEDDE----- 237
            ......:.|..:..:||.:.|||:.:|..:|:|:|||..|:.|            |::|:
Mouse   391 YRVMSYLTEVELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAVSEEGDEDDWISNK 455

  Fly   238 -TCKLADFGLVIDVDRANSHHATEGDSRYMAPEILQGHFS--KAADIFSLGIAMLELACYMDLPS 299
             ..|:.|.|   .|.|.:|....|||||::|.|:||.::|  ..||||:|.:.::..|....||.
Mouse   456 VMFKIGDLG---HVTRISSPQVEEGDSRFLANEVLQENYSHLPKADIFALALTVVCAAGAEPLPR 517

  Fly   300 NGPLWHELRHGILPEEFINKISLELQSVIKSMMKPDPAQRPTAEQLLSHPKLQYLQKKRKSLMNF 364
            ||..|||:|.|.|| .....:|.|:..:::.|:.|||.:||:|.:|:.|..|....:|....:..
Mouse   518 NGEQWHEIRQGRLP-RIPQVLSQEVTELLRVMIHPDPERRPSAMELVKHSVLLSASRKSAEQLRI 581

  Fly   365 SMLSRSFRRS 374
            .:.:..|:.|
Mouse   582 ELNAEKFKNS 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myt1	NP_647987.2	PKc_Myt1	100..349	CDD:270952	88/273 (32%)
Myt1	NP_647987.2	Pkinase	102..349	CDD:278497	88/271 (32%)
Wee1	NP_033542.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..178
		PTKc_Wee1a	292..567	CDD:271040	90/278 (32%)
		Pkinase	298..568	CDD:278497	89/273 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0601
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063695at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1671
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850