DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myt1 and wee-1.1

DIOPT Version :9

Sequence 1:NP_647987.2 Gene:Myt1 / 38649 FlyBaseID:FBgn0040298 Length:533 Species:Drosophila melanogaster
Sequence 2:NP_496058.1 Gene:wee-1.1 / 192085 WormBaseID:WBGene00006938 Length:468 Species:Caenorhabditis elegans


Alignment Length:538 Identity:140/538 - (26%)
Similarity:230/538 - (42%) Gaps:153/538 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 ENSNRFRPPKYKTRGYVAVDNNNLNRS-QSLGSC------STNSSQIAHAISFRDAGCSDSSTLP 82
            :::|:.|||.             :|:: :||.|.      :.:|:||.         ....|.:.
 Worm    46 QSNNKKRPPP-------------INKARKSLPSIFRRAEENKDSAQII---------TPTGSKII 88

  Fly    83 SSPVQAELSTLSLSHFEQCFERLAKLGEGSFGEVFQVRDRSDGQLYAV------KISKQLFRGEQ 141
            .||:...  :.|.|.|:..|.....||:||||||.....||..:.:|:      |:||     :|
 Worm    89 GSPLYKR--SKSDSFFDHAFNFDKNLGKGSFGEVVAATCRSTSKKFAIKKIPFSKLSK-----DQ 146

  Fly   142 YRAERLEEVRRYEEFSGHENCIRFIRAWEQYDRLYMQMELCRESLEQYLLRCQRIPEERIWHILL 206
            ||     |...:.....|.|.:||.:||.....|::|:|:|.:||..|......:.::.:|::.|
 Worm   147 YR-----EAYGHMNIPCHPNIVRFHQAWIDKQILHIQLEMCDKSLAAYCHGIDWLEDKELWNVFL 206

  Fly   207 DLLRGLKSLHDRNLIHLDIKLDNVLIGEDDETCKLADFGLVIDV------DRANSHHATEGDSRY 265
            |:|:||..||:..::|.|||.||:.:.: ::.|||.||||:.|:      :.:|.|:.:|||.:|
 Worm   207 DILQGLGHLHNNFMLHNDIKPDNIFMTK-NKVCKLGDFGLISDMRSEPINNSSNKHYQSEGDGKY 270

  Fly   266 MAPEILQGHFSKAADIFSLGIAMLELACYMDLPSNGPLWHELRHGILPEEFINKISLELQSVIKS 330
            .:.|.:.|..|..:||||.||::||:...:.|||.|..|..:|...:|||.:..:|.||:.::|.
 Worm   271 CSKEAINGTLSIFSDIFSFGISILEVGTNIHLPSYGTGWEPIRKWEIPEEILEPMSDELRELVKQ 335

  Fly   331 MMKPDPAQRPTAEQLLSHPKLQYLQKKRKSLMNFSMLSRSFRRSRRAVWGRMCNWKTAAFRYLLY 395
            ||...|.:|||..:|:.:..::...:.||.                                   
 Worm   336 MMDKAPTRRPTCSELMKNHVVKEKLRIRKQ----------------------------------- 365

  Fly   396 FLEVLHLCKPITASQPNINIVPSSPSSKGVPLVPQVEFQ----LVGSTPIANRD--CYASDFLSG 454
              ||.|              :||           :.:||    |...:|:.:|:  |.:.|||  
 Worm   366 --EVEH--------------IPS-----------ESQFQPISYLTTESPLGSRESSCSSIDFL-- 401

  Fly   455 EDPLDLSNQGSPNVINSTPLNTNQGKSRLDLLKNNVDSMGRYVHVHDFESPCSALSSAKVLDT-- 517
             |..:.:.:.:|.|          .|...||    .|....|   ..|..|.:.:..::...|  
 Worm   402 -DHFENAEKKTPFV----------SKLNFDL----EDDEDEY---EVFSPPRTPVKKSRYQQTMP 448

  Fly   518 ---------SSFRRKKLF 526
                     ..|:||.||
 Worm   449 EVSPPRKIQKLFQRKNLF 466

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myt1NP_647987.2 PKc_Myt1 100..349 CDD:270952 91/260 (35%)
Pkinase 102..349 CDD:278497 91/258 (35%)
wee-1.1NP_496058.1 PKc_Myt1 104..354 CDD:270952 91/260 (35%)
Pkinase 106..352 CDD:278497 91/256 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160167528
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0601
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1063695at2759
OrthoFinder 1 1.000 - - FOG0003337
OrthoInspector 1 1.000 - - otm14413
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11042
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
98.810

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