DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myt1 and wee2

DIOPT Version :9

Sequence 1:	NP_647987.2	Gene:	Myt1 / 38649	FlyBaseID:	FBgn0040298	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001096499.1	Gene:	wee2 / 100125126	XenbaseID:	XB-GENE-5560750	Length:	562	Species:	Xenopus tropicalis

Alignment Length:	413	Identity:	113/413 - (27%)
Similarity:	174/413 - (42%)	Gaps:	75/413 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 QCNGE-------------------NSNRFRPPKYKTRGYVAVDNNNLNRSQSLGSCSTNS----S 62
            ||.|:                   |.|.|.|..|:...:   ..|...:.:....||...    :
Frog   128 QCRGQRLLRFVAGTGAELDDPALVNVNPFTPESYRQANF---HPNGKRKERPEDDCSAEPQMKYA 189

  Fly    63 QIAHAISFRDAGCSDSSTLPSSPVQAELSTLSLSHFEQCFERLAKLGEGSFGEVFQVRDRSDGQL 127
            :..|...|:    |....|        ..|..:|.::..|..:.|:|.|.||.||:...|.||..
Frog   190 EKEHPAVFQ----SKRFVL--------RETNMVSRYKTEFLEIEKIGAGEFGSVFKCVKRLDGCF 242

  Fly   128 YAVKISKQLFRGEQYRAERLEEVRRYEEFSGHENCIRFIRAWEQYDRLYMQMELCR-ESLEQYLL 191
            ||:|.||:...|.......|.||..:.....|.:.:|:..||.:.|.:.:|.|.|. .||:..::
Frog   243 YAIKRSKKPLAGSTDEQLALREVYAHAVLGHHPHVVRYYSAWAEDDHMIIQNEYCNGGSLQDLIM 307

  Fly   192 RCQR----IPEERIWHILLDLLRGLKSLHDRNLIHLDIKLDNVLI-------------GEDDETC 239
            ..::    :||:.:..|||.:..|||.:|...|:|:|||..|:.|             ||||.:.
Frog   308 ENKKEGRFVPEQELKEILLQVSMGLKYIHSSGLVHMDIKPSNIFICRKQTEVGQDESDGEDDLSS 372

  Fly   240 -----KLADFGLVIDVDRANSHHATEGDSRYMAPEILQGHFSK--AADIFSLGIAMLELACYMDL 297
                 |:.|.|.|..:   .:....|||||::|.||||..:.:  .||||:||:.:...|....|
Frog   373 ASVLYKIGDLGHVTSI---LNPQVEEGDSRFLANEILQEDYRQLPKADIFALGLTITLAAGAGPL 434

  Fly   298 PSNGPLWHELRHGILPEEFINKISLELQSVIKSMMKPDPAQRPTAEQLLSHP-------KLQYLQ 355
            |.|...||.:|.|.|| .....::....:::|.::.|||..||.|..|..:.       |...||
Frog   435 PCNEDSWHHIRKGNLP-HIPQPLTPAFLALLKLLVHPDPVMRPPAVSLAKNSLLRRCVGKAAQLQ 498

  Fly   356 KK-RKSLMNFSMLSRSFRRSRRA 377
            |: .......:||.|..:.::.|
Frog   499 KQLNVEKFKTAMLERELKAAKLA 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myt1	NP_647987.2	PKc_Myt1	100..349	CDD:270952	88/273 (32%)
Myt1	NP_647987.2	Pkinase	102..349	CDD:278497	88/271 (32%)
wee2	NP_001096499.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..86
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..181		2/22 (9%)
		PKc_like	216..486	CDD:389743	88/273 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063695at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1671
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.950