DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myt1 and pkmyt1

DIOPT Version :9

Sequence 1:	NP_647987.2	Gene:	Myt1 / 38649	FlyBaseID:	FBgn0040298	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001091666.1	Gene:	pkmyt1 / 100049158	ZFINID:	ZDB-GENE-060810-80	Length:	554	Species:	Danio rerio

Alignment Length:	566	Identity:	180/566 - (31%)
Similarity:	243/566 - (42%)	Gaps:	145/566 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 TNSSQIAHAISFRD-----AGCSDSSTLPSSPVQAEL---------STLS------------LSH 97
            |:.|...|:|:.:.     :..||||..||.|:...|         |.:|            |||
Zfish    19 THFSNAQHSITVKKRKPPFSNLSDSSQSPSPPLYHSLPPRPPSKGCSPVSRVFPHRSIQWTPLSH 83

  Fly    98 --------------------FEQCFERLAKLGEGSFGEVFQVRDRSDGQLYAVKISKQLFRGEQY 142
                                |.|||..|..:|.|||||||:|...:|...||||.|...||.|..
Zfish    84 SLIESPPPLSVYDPSQQQSFFSQCFTNLGLIGRGSFGEVFKVVSLTDNCQYAVKRSVHRFRSEVE 148

  Fly   143 RAERLEEVRRYEEFSGHENCIRFIRAWEQYDRLYMQMELCRESLEQYLLRCQRIP----EERIWH 203
            ||:.:.|...:||...|...:.||.|||:...||:|.|||..||   ||..:..|    |.|.|.
Zfish   149 RAKSITEAWNHEELHPHPYILGFIAAWEEAGHLYIQTELCCTSL---LLFAEETPCHTGEMRAWA 210

  Fly   204 ILLDLLRGLKSLHDRNLIHLDIKLDNVLIGEDDETCKLADFGLVIDVDRANSHHAT--------- 259
            .|.|:|..|..|||....|||||..|..|.:... .||.||||:|.:. ||:....
Zfish   211 YLCDMLSALIHLHDCGFAHLDIKPANFFITKSGR-LKLGDFGLLIKLP-ANAQKQVNEEKREMKK 273

  Fly   260 ------EGDSRYMAPEILQGHFSKAADIFSLGIAMLELACYMDLPSNGPLWHELRHGILPEEFIN 318
                  |||.||||||:|:|.:..|||||||||::|||||.:::|..|..|..||:|.|||||.|
Zfish   274 ERDDLQEGDPRYMAPELLRGDYGTAADIFSLGISILELACNIEVPKEGDDWQLLRNGHLPEEFTN 338

  Fly   319 KISLELQSVIKSMMKPDPAQRPTAEQLLSHPKLQYLQKKRKSLMNFSMLSRSFRRSRRAVWGRMC 383
            .:|.|:..:::.|:.|:|..|.||:||||.|   :::|.:.....:..:..||.        .:.
Zfish   339 VLSEEMLYILRLMLTPEPCNRATAQQLLSLP---FVRKHKWRRHLYLCIIESFL--------TLF 392

  Fly   384 NWKTAAFRYLLYFLEVLHLCKPITASQPNINIVPSSPSSKGVPLVPQVEFQLVGSTPIANRDCYA 448
            .|..:.|.....|:..|.|          :...|.|.||            |..|||...|
Zfish   393 QWSQSLFYGSWNFISSLSL----------LFKTPVSESS------------LSTSTPPRER---- 431

  Fly   449 SDFLSGEDPLDLSNQGS------------PNVINSTPLNTNQGKSRLD-------LLKNNVDSMG 494
                 .|...|:||..|            |:|...:|..|::.:|||.       |.:::.|.:.
Zfish   432 -----WERDADISNIQSYSESPIHHCVFPPDVSEHSPTYTHRVQSRLSSGSTSTLLPESDNDVID 491

  Fly   495 RYVHVHDFESP-------CSALSSAKVLDTSSFRRKKLFVLEYDDE 533
            ...|.....||       .|:|...|:.|:       |.:.|.|.|
Zfish   492 ASSHNQCIPSPPRSHYSSSSSLIHNKLTDS-------LCIHERDTE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myt1	NP_647987.2	PKc_Myt1	100..349	CDD:270952	119/267 (45%)
Myt1	NP_647987.2	Pkinase	102..349	CDD:278497	117/265 (44%)
pkmyt1	NP_001091666.1	PKc_Myt1	106..369	CDD:270952	119/267 (45%)
pkmyt1	NP_001091666.1	S_TKc	108..371	CDD:214567	118/270 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596304
Domainoid	1	1.000	190	1.000	Domainoid score	I3205
eggNOG	1	0.900	-	-		E1_KOG0601
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1063695at2759
OrthoFinder	1	1.000	-	-		FOG0003337
OrthoInspector	1	1.000	-	-		oto41578
orthoMCL	1	0.900	-	-		OOG6_104974
Panther	1	1.100	-	-	LDO	PTHR11042
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1671
SonicParanoid	1	1.000	-	-		X4326
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.740