DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myt1 and eif2ak2

DIOPT Version :9

Sequence 1:	NP_647987.2	Gene:	Myt1 / 38649	FlyBaseID:	FBgn0040298	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001107942.1	Gene:	eif2ak2 / 100001092	ZFINID:	ZDB-GENE-080422-1	Length:	682	Species:	Danio rerio

Alignment Length:	383	Identity:	95/383 - (24%)
Similarity:	160/383 - (41%)	Gaps:	101/383 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 SQSLGSC-------STNSSQIAHAISFRDAGCSDSSTLPSSP------VQAEL------------ 90
            |||..:|       |.|:|..::.|||||:..:.||.:.:||      |:.::
Zfish   295 SQSQDTCKSEDVQRSANASSTSNFISFRDSAAAASSPMATSPSVSLVDVKPKIKLAPRFLLPNGL 359

  Fly    91 ------------------------STLSLSHFEQCFERLAKLGEGSFGEVFQVRDRSDGQLYAVK 131
                                    ::.:.|.|.:.|:.:..:|:|.||.||:.|.:.:.:.||||
Zfish   360 DRSKEGGPDMKVPNPAKASGGQTPNSATKSRFLEDFDSINPIGKGGFGRVFKARRKLEDKYYAVK 424

  Fly   132 ISKQLFRGEQYRAERLEEVRRYEEFSGHENCIRFIRAWEQ---YDR-----------------LY 176
            |.|...:..:       ||....:|: :.|.:|:..:||:   |..                 ||
Zfish   425 IVKSTEKARR-------EVGALADFN-NPNIVRYFSSWEEDTAYKHESSESFSDSGSGPGTKFLY 481

  Fly   177 MQMELCRESLEQYLLRC---------QRIPEER--IWHILLDLLRGLKSLHDRNLIHLDIKLDNV 230
            :|||.|    |...||.         ::.||.|  ...|...:|:.::.:|.:.|||.|:|..|:
Zfish   482 IQMEFC----EGNTLRVWIKERNSSNKQSPERRTEAAQIYRQVLKAVEYIHSKLLIHRDLKPPNI 542

  Fly   231 LIGEDDETCKLADFGLVIDVDRANSHHATE-----GDSRYMAPEIL-QGHFSKAADIFSLGIAML 289
            :...:... |:.|||||...:..|.....|     |...||:||.: |..:.:..||::||:...
Zfish   543 MFSSEGRV-KVGDFGLVTAAENENEEQLLERTKRTGTRTYMSPEQMNQTTYDRKVDIYALGLIYF 606

  Fly   290 ELACYM-DLPSNGPLWHELRHGILPEEFINKISLELQSVIKSMMKPDPAQRPTAEQLL 346
            ||...: .:.....:|.:||..:.|.:|......| ..:::.|:.|.|..||.|..|:
Zfish   607 ELVWNLGTMHEKEKIWDKLRVRVFPVQFTKMFIFE-HKLMERMLSPRPEDRPDATDLI 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myt1	NP_647987.2	PKc_Myt1	100..349	CDD:270952	76/285 (27%)
Myt1	NP_647987.2	Pkinase	102..349	CDD:278497	76/283 (27%)
eif2ak2	NP_001107942.1	double stranded RNA-binding domain I	7..75
		DSRM	8..74	CDD:214634
		double stranded RNA-binding domain II	99..170
		DSRM	104..168	CDD:214634
		double stranded RNA-binding domain III	212..280
		DSRM	213..278	CDD:214634
		PKc_like	389..666	CDD:304357	78/289 (27%)
		protein kinase domain	395..682		76/283 (27%)
		S_TKc	395..662	CDD:214567	75/280 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910