DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scny and UBP10

DIOPT Version :9

Sequence 1:	NP_729092.1	Gene:	scny / 38648	FlyBaseID:	FBgn0260936	Length:	1038	Species:	Drosophila melanogaster
Sequence 2:	NP_014213.2	Gene:	UBP10 / 855535	SGDID:	S000005130	Length:	792	Species:	Saccharomyces cerevisiae

Alignment Length:	582	Identity:	135/582 - (23%)
Similarity:	230/582 - (39%)	Gaps:	150/582 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SSAGSSTDQAKSGED------TNGSLQNHIVANAKRILMAKIEYEEVPNYHESVLENLKSKYIVI 84
            |::.||.|:.:..||      .:.:::..:....:....:||...|..:.::.::||
Yeast   221 STSISSDDEIEDDEDEDDMDYDSSAMEKELPEEEENDSSSKISEGEKKSLYQDLMEN-------- 277

  Fly    85 KPGNPGAINGFSGKNNTGKLVGANGHDNNGARKQAEHPNNQSHHINHHNHQHPTSNPNELPKPKR 149
               :...:|.:...|||.:    ||:.|    .:.|....:...:.|.:..  .:.|..:.....
Yeast   278 ---STVEVNRYEPVNNTKE----NGNRN----PKGEEEEEEEEELKHKSRS--ITPPVTISNLSN 329

  Fly   150 VLYPRENI---------RI----GWKQSERKWQVGTGMINVGNTCYLNSTLQALLHIPALANWLV 201
            .....|||         ||    |.|.:..|   ..|::|.|.|||.|:.:||:||||::.::|.
Yeast   330 FYQFNENINDRGSLNSTRIVKNWGDKFTNLK---PRGLLNHGVTCYTNAAVQAMLHIPSIQHYLF 391

  Fly   202 SEQAHLADCNVAEPGSGCIICAMTKTL-LATQSN------QSAVRPFLIYSKLKQICKHMVVGRQ 259
            .......|..:::......:...:|.: |....|      .|.:.|..:.|:|..|...|...:|
Yeast   392 DILMGKYDSTISKNSVSYTLAETSKKMWLPVSKNPRKNVSASYINPKHLISRLDDINCMMSEWQQ 456

  Fly   260 EDAHEFLRFLVEAMERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHF 324
            ||:||:...|:..::...:.  :.:|.::.::.:      ||||.|:..|.|.||..:|.|.|.|
Yeast   457 EDSHEYFMSLMSRLQEDSVP--KGHKLIESIIYD------IFGGLLKQIVTCKSCGSISKTEQPF 513

  Fly   325 QDLLLDI---RKAD--------------------------------------------------- 335
            .||.|.:   :|.|
Yeast   514 YDLSLHLKGKKKLDPNSDLSSDSINGTSATTSTTTSNAATKPSLSSSSSVNLNNGSPFAAASDLS 578

  Fly   336 ------SLEDAFEGHFSRERL----EDMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFSMIG 390
                  |:|.:.:..|:.|.:    |..||.||.|.|..:|.|..|:.|||.||.:.||:|...|
Yeast   579 SANRRFSIEKSIKDFFNPELIKVDKEQKGYVCEKCHKTTNAVKHSSILRAPETLLVHLKKFRFNG 643

  Fly   391 ---NKLTKQISFKSRIDLSKYAARSQAAQAQPLTYRLVSMVTHLGASQHCGHYTAIGSTDTGSFY 452
               :|:.:.:|:...:||::|....:.    |:.|:|:|:|.|.|.|...|||.|......||:.
Yeast   644 TSSSKMKQAVSYPMFLDLTEYCESKEL----PVKYQLLSVVVHEGRSLSSGHYIAHCKQPDGSWA 704

  Fly   453 NFDDSYVRPIAMHSVC-NTNAYIMFF--------ELDLSQAA------------SPAANRPN 493
            .:||.|:..|:...|. ..|||.:.:        .|.|:::|            ..|.|.||
Yeast   705 TYDDEYINIISERDVLKEPNAYYLLYTRLTPKSVPLPLAKSAMATGNVTSKSKQEQAVNEPN 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scny	NP_729092.1	Peptidase_C19E	171..477	CDD:239126	99/380 (26%)
		UCH	172..477	CDD:278850	99/379 (26%)
		Asp-B-Hydro_N	<617..>731	CDD:191249
UBP10	NP_014213.2	PRK05901	28..>221	CDD:235640	135/582 (23%)
UBP10	NP_014213.2	UCH	362..730	CDD:395355	99/379 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	154	1.000	Domainoid score	I906
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1006
TreeFam	1	0.960	-	-
	4	3.870