DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scny and UBP23

DIOPT Version :9

Sequence 1:	NP_729092.1	Gene:	scny / 38648	FlyBaseID:	FBgn0260936	Length:	1038	Species:	Drosophila melanogaster
Sequence 2:	NP_568873.1	Gene:	UBP23 / 835910	AraportID:	AT5G57990	Length:	859	Species:	Arabidopsis thaliana

Alignment Length:	1001	Identity:	250/1001 - (24%)
Similarity:	401/1001 - (40%)	Gaps:	225/1001 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 TDQAKSGEDTNGSLQNHIVANAKRILMAKIEYEEVPNYHESVLENLKSKYIVIKPGNPGAINGFS 96
            ||:..| .:.|||..  :.::....:..|||:....                 ||     .||||
plant    14 TDRDPS-SNNNGSCA--VASSTASAVFRKIEFHPAR-----------------KP-----FNGFS 53

  Fly    97 GKNNTGKLVGANGHDNNG---ARKQAEHPNNQSHHINHHNHQHPTSNPNELPKPKRVLYPRENIR 158
            ...:..|:...|...:|.   :...|:.|:  |..:..|..:                 |.....
plant    54 NGRSDFKIETLNPCSSNQRLLSAPSAKKPD--SSDLLEHGFE-----------------PDLTFS 99

  Fly   159 IGWKQSERKWQVGTGMINVGNTCYLNSTLQALLHIPALANWLVSEQAHLADCNVAEPGSGCIICA 223
            |.::      ::|.|:.|:||||:|||.||.|.:...||..| ...||...|:||   ..|.:||
plant   100 ITFR------KIGAGLQNLGNTCFLNSVLQCLTYTEPLAATL-QTAAHQKYCHVA---GFCALCA 154

  Fly   224 MTKTL-LATQSNQSAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLVEAMERAYLMRFRNYKEL 287
            :.|.: .|.|:|...:.|..:.|.|:.|.::....|||||||::..|:|.|.:..|......:..
plant   155 IQKHVRTARQANGRILAPKDLVSNLRCISRNFRNCRQEDAHEYMINLLECMHKCSLPSGVPSESS 219

  Fly   288 DQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADSLEDAFEGHFSRERLED 352
            |...:..  :.:||||.|||:|:|..|:|.|..|..|.||.|||.|||||:.|. ..|:...|.|
plant   220 DAYRRSL--VHKIFGGSLRSQVKCEQCSHCSNKFDPFLDLSLDISKADSLQRAL-SRFTAVELLD 281

  Fly   353 MG---YKCEGCKKKVSATKQFSLERAPITLCIQLKRF-SMIGNKLTKQISFKSRIDLSKYAARSQ 413
            .|   |:||.||:||.|.||.::.:||..|.:.|||| :....|:.:::.|.|.||:..:.:...
plant   282 NGAKVYQCERCKQKVKAKKQLTVSKAPYVLTVHLKRFEAHRSEKIDRKVDFTSAIDMKPFVSGPH 346

  Fly   414 AAQAQPLTYRLVSMVTHLGASQHCGHYTAIGSTDTGSFYNFDDSYVRPIAMHSVCNTNAYIMFFE 478
            ...   |.|.|..::.|.|.|.|.|||.....|.:|.:|:.||:.|..::..:|.|..||::|:.
plant   347 EGN---LKYTLYGVLVHYGRSSHSGHYACFVRTSSGMWYSLDDNRVVQVSEKTVFNQKAYMLFYV 408

  Fly   479 LDLSQAA-----------SPAANRPNGVRLTN----GHSTTPVP-----AATVSSPSPTRFIGPQ 523
            .|...|.           |.|.||.:.:..:|    .:.:|.:.     |...:..:|.:..||.
plant   409 RDRQNAVPKNSVPVVKKESFATNRASLIVASNIKDQVNGSTVIKECGFGALVANGLAPLKSCGPS 473

  Fly   524 LPAGGANGYTNGNAQKTAIQFKQQNQQSPQNGLQLGTGKFQDTAKPPLVGAHAKGEATSAPTANG 588
            .||              .:..|..|.:..||. .:...:.::..:.....|..|....:|||...
plant   474 TPA--------------VLTQKDLNAKETQNN-AISNVEAKEILETENGSAPVKTCDLAAPTVLV 523

  Fly   589 NKSSSPSSNSSSNHKSINQQQY-LPISSDDEDIEDEMKPRPTTAQLPSMPNMTENHTEPKAKSPV 652
            .|        ..|.|.|.|::. ||.::.:..:..|    .:.|....:|.....|.:..|.:
plant   524 QK--------DLNTKEIFQKEVPLPQANGEGSLVKE----DSKAACLILPEKVSPHLDGSANA-- 574

  Fly   653 KIQVKTPVKTPLKSLVPYESASEEEEAPLPNPRKRPSGEDSSESDQESGQTNGHSKTNGSHTNGS 717
                :|.||.|  :|.|....|.||:..|.|                              .|..
plant   575 ----QTLVKLP--TLGPKAENSVEEKNSLNN------------------------------LNEP 603

  Fly   718 ASS----SVHVNNSK-QKTDAIDEIF-KSLKKSADSDEDDDEEEPSIQLTNGWHPQKQSQSQSKA 776
            |:|    :|.|.|.. :|...||:.. ..|::||.|.|       |::||        |:.::..
plant   604 ANSLKVINVSVGNPPVEKAVLIDQTMGHHLEESATSIE-------SLKLT--------SERETLT 653

  Fly   777 PPSPKTPPSPAVIKSKTGIWKVT---RNDEVDAIEDDVDVVVVEGSPVKIPTPNKNHRNPFSSSK 838
            .|.....|....:|.:...:|:.   |..:|...|.....|..|....::.:..:......|...
plant   654 TPKKTRKPKTKTLKVEFKFFKLALGLRKKKVQRRERLSTTVAGEIISEELLSKKRVKYQDTSLIA 718

  Fly   839 PSTDSPATPGAKRQKLLNGS--ALKSHQQPRVGNGYQSNATSNGSTINE---LLKQSY----RGY 894
            ||            |:::.|  |:.|.||..||:...|.|:.|.....|   |.|::.    ||.
plant   719 PS------------KMISSSDGAVTSDQQQPVGSSDLSEASQNAKRKRESVLLQKEAVNILTRGV 771

  Fly   895 GSPVLSWNGKPAELEKELLVDAREQRQRD-------IDDDEENEMDRGRQRKVKSGSAKGNNASN 952
            ...|:      |:.::|:....:...:.:       :.|:.:.|.|||:::|::.       ...
plant   772 PETVV------AKWDEEISASQKRGSKSEGASSIGYVADEWDEEYDRGKKKKIRI-------KEE 823

  Fly   953 STPGYNPFQ------EYEGQKRWNKN 972
            |..|.||||      :.|.:|:|.::
plant   824 SYRGPNPFQMLASKRQKETKKKWTQS 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scny	NP_729092.1	Peptidase_C19E	171..477	CDD:239126	115/310 (37%)
		UCH	172..477	CDD:278850	114/309 (37%)
		Asp-B-Hydro_N	<617..>731	CDD:191249	22/118 (19%)
UBP23	NP_568873.1	Peptidase_C19E	106..408	CDD:239126	116/311 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1057
eggNOG	1	0.900	-	-		E1_KOG1865
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000177
OrthoInspector	1	1.000	-	-		otm2471
orthoMCL	1	0.900	-	-		OOG6_101457
Panther	1	1.100	-	-	LDO	PTHR24006
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1006
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.770