DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scny and Usp42

DIOPT Version :9

Sequence 1:	NP_729092.1	Gene:	scny / 38648	FlyBaseID:	FBgn0260936	Length:	1038	Species:	Drosophila melanogaster
Sequence 2:	NP_084025.2	Gene:	Usp42 / 76800	MGIID:	1924050	Length:	1324	Species:	Mus musculus

Alignment Length:	1101	Identity:	276/1101 - (25%)
Similarity:	445/1101 - (40%)	Gaps:	288/1101 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 GAINGFSGKNN----TGKLVGANGHDNNGARKQAEHPNNQSHHINHHNHQHPTSNPNE------L 144
            ||::..|..::    .|.:.||..:.|:...::::                 .|.|.:      :
Mouse    38 GAVSSISDVSSHTLPLGPVPGAVVYSNSSVPEKSK-----------------PSPPKDQVLGDGI 85

  Fly   145 PKPKRVLYPRENIRIGWKQSERKWQVGTGMINVGNTCYLNSTLQALLHIPALANWLVSEQAHLAD 209
            ..|::||:|.|.|.:.|:||.|   ||.|:.|:||||:.|:.||.|.:.|.|||:::|.: |...
Mouse    86 APPQKVLFPSEKICLKWQQSHR---VGAGLQNLGNTCFANAALQCLTYTPPLANYMLSHE-HSKT 146

  Fly   210 CNVAEPGSGCIICAMTKTLLATQSNQ-SAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLVEAM 273
            |: ||  ..|::|.|...:....||. ..::|..:.:::::|.:|...|.||||||||::.|:||
Mouse   147 CH-AE--GFCMMCTMQTHITQALSNPGDVIKPMFVINEMRRIARHFRFGNQEDAHEFLQYTVDAM 208

  Fly   274 ERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADSLE 338
            ::|.|   ....:||:..:.||.:.|||||||||.|:||:|..||.||..:.|:.|:|:.|.|:.
Mouse   209 QKACL---NGSNKLDRHTQATTLVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDITLEIKAAQSVT 270

  Fly   339 DAFEGHFSRERLE-DMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRF-SMIGNKLTKQISFKS 401
            .|.|.....|:|: :..|||..|||.|.|:|:|::.|:...|.|.|||| :..|.|:.|.:.:..
Mouse   271 KALEQFVKPEQLDGENSYKCSKCKKMVPASKRFTIHRSSNVLTISLKRFANFTGGKIAKDVKYPE 335

  Fly   402 RIDLSKYAARSQAAQAQPLTYRLVSMVTHLGASQHCGHYTAIGSTDTGSFYNFDDSYVRPIAMHS 466
            .:|:..|.::   ...:|:.|.|.:::.|.|.:.|.|||........|.:|..:||.|....:.:
Mouse   336 YLDIRPYMSQ---PNGEPIIYVLYAVLVHTGFNCHAGHYFCYIKASNGLWYQMNDSIVSTSDIRA 397

  Fly   467 VCNTNAYIMFFELDLSQAASPAANRPNGVRLTNGHSTTPVPAATVSSPSP-------------TR 518
            |.|..||::|:            .|.:.|: ..|.|..|..:...|||.|             ..
Mouse   398 VLNQQAYVLFY------------IRSHDVK-NGGESAHPAHSPGQSSPRPGVSQRVVNNKQVAPG 449

  Fly   519 FIGPQLPAGGANGYTNGNAQKTAIQFKQQNQQSPQNGLQLGTGKFQDTAKPPLVGAHAKGEATSA 583
            |||||||:.......:.|                      ||...:||            .::|.
Mouse   450 FIGPQLPSHVMKNTPHLN----------------------GTTPVKDT------------PSSSV 480

  Fly   584 PTANGNKS---SSPSSNSSS-NHKSINQQQYLPISSDDEDIEDEMKPRPTTA----QLPSMPNMT 640
            .:.|||.|   :||::.|:| .:.|:.:...:|         |..|.:..|.    :||:.....
Mouse   481 SSPNGNTSVNRASPATASTSVQNWSVTRPSVIP---------DHPKKQKITISIHNKLPARQGQA 536

  Fly   641 ENHTE---PKAKSPVKIQVKTPVKTP----LKSLVPYESASEEEEAPLP--NPRKR-------PS 689
            ..:..   |..::|.|....:.:..|    ..|.||..|.|..|..|.|  |.:.:       |.
Mouse   537 PLNNSLHGPCLEAPSKAAPSSTITNPSAIQSTSNVPTTSTSPSEACPKPMVNGKAKVGASVLVPY 601

  Fly   690 G-EDSSESDQES---GQTNGHSKTNGSHT-------NGSASSSVHVNNSKQKTDAIDEIFKSLKK 743
            | |.|.|||:||   .:.||.....|:|:       :..|.:|.|        :..:.:..:...
Mouse   602 GAESSEESDEESKGLAKENGVDMMAGTHSDRPEAAADDGAEASSH--------ELQEPVLLNGAN 658

  Fly   744 SADSDEDDDE---EEPSIQLTNGWHPQK-----------------QS------------QSQSKA 776
            |||||..::.   :..|.|:....|.:.                 ||            .:|:|.
Mouse   659 SADSDSQENSLAFDSASCQVQPELHTENLFSKLNGLPGKVTPAPLQSVPEDRILETFKLTNQAKG 723

  Fly   777 P-----------PSPKTP----------PSP-----AVIKSKTGIWKVTRNDE--VDAIEDDVDV 813
            |           .|||.|          |||     ||....|.....|...|  :...::|..|
Mouse   724 PAGEESWTTTGGSSPKDPVSQLEPISDEPSPLEIPEAVTNGSTQTPSTTSPLEPTISCTKEDSSV 788

  Fly   814 VV----VEGSPVKIP------------TPNKNHRNPFS-SSKPSTDSPATPGAKRQKLLNGSALK 861
            ||    |||.| .:|            ||.....:|.. ::.||..:.|..|...:|..:.:..:
Mouse   789 VVSAEPVEGLP-SVPALCNSTGTILGDTPVPELCDPGDLTANPSQPTEAVKGDTAEKAQDSAMAE 852

  Fly   862 SHQQ----PRV--GNGYQSN----ATSNGSTINELLKQSYRGYGSPVLSWNGKPAELEKELLVDA 916
            ..::    |.|  |:|.:..    .::.||   |..:.|.|.......:...||..........|
Mouse   853 VVERLSPAPSVLTGDGCEQKLLLYLSAEGS---EETEDSSRSSAVSADTMPPKPDRTTTSSCEGA 914

  Fly   917 REQRQRDIDD------------------DEENEMDRGRQRKVKSGSAKGNNASNSTPGYNPFQEY 963
            .||...|..|                  ....::|||..|..:..|:.|.:..:|.|  .| :::
Mouse   915 AEQAAGDRGDGGHVGPKAQEPSPAKEKMSSLRKVDRGHYRSRRERSSSGEHVRDSRP--RP-EDH 976

  Fly   964 EGQKRWNKNGGGGGFPRFYNQNYRQNFQQRNKFKFNRF--GGP----GSAKFQQQRALQRH 1018
            ..:||               ..|.:...::::...|.:  ||.    |.....::|:|.|:
Mouse   977 HHKKR---------------HCYSRERPKQDRHPTNSYCNGGQHLGHGDRASPERRSLSRY 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scny	NP_729092.1	Peptidase_C19E	171..477	CDD:239126	112/308 (36%)
		UCH	172..477	CDD:278850	111/307 (36%)
		Asp-B-Hydro_N	<617..>731	CDD:191249	34/144 (24%)
Usp42	NP_084025.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		276/1101 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..86		3/38 (8%)
		Peptidase_C19E	109..409	CDD:239126	113/321 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	417..517		31/142 (22%)
		Herpes_BLLF1	<420..795	CDD:282904	92/425 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..587		11/37 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	624..676		10/59 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	717..780		15/62 (24%)
		Sporozoite_P67	<723..>870	CDD:253298	34/147 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	816..847		7/30 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	880..1026		31/164 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1145..1262
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1303..1324
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	209	1.000	Domainoid score	I2834
eggNOG	1	0.900	-	-		E1_KOG1865
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3195
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000177
OrthoInspector	1	1.000	-	-		otm44363
orthoMCL	1	0.900	-	-		OOG6_101457
Panther	1	1.100	-	-	LDO	PTHR24006
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1006
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.860