Protein Alignment scny and USP17L5

DIOPT Version :10

• Sequence 1: NP_729092.1
• Gene: scny / 38648
• FlyBaseID: FBgn0260936
• Length: 1038
• Species: Drosophila melanogaster
• Sequence 2: NP_001229258.1
• Gene: USP17L5 / 728386
• HGNCID: 37177
• Length: 530
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 145/511 - (28%)
• Similarity: 230/511 - (45%)
• Gaps: 71/511 - (13%)

  Fly   142 NELPKPKRVLYPRENIRIGWKQSERKWQVGTGMINVGNTCYLNSTLQALLHIPALANWLVSEQAH 206
            ::|....|.|.|||.:.:   .|.|...||.|:.|:|||||:|::||.|.:.|.|||:::|.: |
Human    53 DDLAPVARQLAPREKLPL---SSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLSRE-H 113

  Fly   207 LADCNVAEPGSGCIICAMTKTLLATQSNQSAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLVE 271
            ...|:   ...||::|.|...:.....|     |..:....:.:......|:||||||||.|.|:
Human   114 SQTCH---RHKGCMLCTMQAHITRALHN-----PGHVIQPSQALAAGFHRGKQEDAHEFLMFTVD 170

  Fly   272 AMERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADS 336
            ||::|.|   ..:|::|...|:||.:.||||||.||:::||.|:.:|.||..:.|:.|||:.|.|
Human   171 AMKKACL---PGHKQVDHHSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQS 232

  Fly   337 LEDAFEGHFSRERLE-DMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFS-MIGNKLTKQISF 399
            ::.|.|.....|.|. :..|.|..|.::..|:|..:|..:...|.:.||||| :.|||:.|.:.:
Human   233 VQQALEQLAKPEELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRFSDVTGNKIAKNVQY 297

  Fly   400 KSRIDLSKYAARSQAAQAQPLTYRLVSMVTHLGASQHCGHYTAIGSTDTGSFYNFDDSYVRPIAM 464
            ...:|:..|.::....   ||.|.|.:::.|.|.|.|.|||.:......|.:|..||:.|...::
Human   298 PECLDMQPYMSQPNTG---PLVYVLYAVLVHAGWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSI 359

  Fly   465 HSVCNTNAYIMFF----ELDLSQAASPAANRPNGV-------RLTNGHSTTPVPAATVSSPSPTR 518
            .||.:..||::|:    |.:....:......|..:       |.|.|......|..
Human   360 TSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRATQGELKRDHPCL--------- 415

  Fly   519 FIGPQLPAGGANGYTNGNAQKTAIQFK---QQNQQSPQNGLQLGTGKFQDTAKPPLVGAHAKGEA 580
                |.|....:.......:.|...:|   :||:..|:..::    |.:.|..|.::..|
Human   416 ----QAPELDEHLVERATQESTLDHWKFLQEQNKTKPEFNVR----KVEGTLPPDVLVIH----- 467

  Fly   581 TSAPTANGNKSSSPSSNSSSNHKSINQQQYLPISSDDEDIEDEMKPRPTTAQLPSM 636
                       .|.......||....|...|.:||.....::.|    .|..|.|:
Human   468 -----------QSKYKCGMKNHHPEQQSSLLNLSSSTPTHQESM----NTGTLASL 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scny	NP_729092.1	Peptidase_C19E	171..477	CDD:239126	107/307 (35%)
USP17L5	NP_001229258.1	Peptidase_C19E	79..373	CDD:239126	108/308 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	382..412		4/29 (14%)
		HABP4_PAI-RBP1	<417..454	CDD:461421	6/40 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..530		10/36 (28%)