Protein Alignment scny and Usp36

DIOPT Version :10

• Sequence 1: NP_729092.1
• Gene: scny / 38648
• FlyBaseID: FBgn0260936
• Length: 1038
• Species: Drosophila melanogaster
• Sequence 2: XP_036012906.1
• Gene: Usp36 / 72344
• MGIID: 1919594
• Length: 1127
• Species: Mus musculus
• Alignment Length: 1129
• Identity: 273/1129 - (24%)
• Similarity: 462/1129 - (40%)
• Gaps: 257/1129 - (22%)

  Fly    37 SGEDTNGSLQNHIVANAKRILMAKIEYEEVPNYHESVLENLKSKYIVIKPGNPGAINGFSGKNNT 101
            |.||  |.|...:.|:||::|:.:||:|.........||:|||||:::                :
Mouse    47 SAED--GDLGRLLAASAKKVLLQRIEFEPASKSFSYQLESLKSKYVLL----------------S 93

  Fly   102 GKLVGANGHDNNGARKQAEHPNNQSHHINHHNHQHPTSNPNELPKPKRVLYPRENIRIGWKQSER 166
            .:..||:.| .:|...||..|..:         :...|..:.:|.|::||:|.|.:.:.|   ||
Mouse    94 ARAEGASRH-RSGDELQARKPGTE---------RVSGSGGDGVPAPQKVLFPVERLSLRW---ER 145

  Fly   167 KWQVGTGMINVGNTCYLNSTLQALLHIPALANWLVSEQAHLADCNVAEPGSGCIICAMTKTLLAT 231
            .::||.|:.|:||||:||||:|.|.:.|.|||:|:|:: |...|:   .|..|::|.|...::..
Mouse   146 VFRVGAGLHNLGNTCFLNSTIQCLTYTPPLANYLLSKE-HARSCH---QGGFCMLCLMQNHMVQA 206

  Fly   232 QSNQ-SAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLVEAMERAYLMRFRNYKELDQLVKETT 295
            .:|. :|::|......||:|.:|...|.|||||||||:.::||::|.|   ..|.:||:..:.||
Mouse   207 FANSGNAIKPVSFIRDLKKIARHFRFGNQEDAHEFLRYTIDAMQKACL---NGYAKLDRQTQATT 268

  Fly   296 PLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADSLEDAFEGHFSRERLE-DMGYKCEG 359
            .:.|||||||||.|:|..|..||.|:..:.|:.|:||:|.::..|.|.....:.|. :..|.|..
Mouse   269 LVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDIALEIRQAANIVRALELFVKSDVLSGENAYMCAK 333

  Fly   360 CKKKVSATKQFSLERAPITLCIQLKRF-SMIGNKLTKQISFKSRIDLSKYAARSQAAQAQPLTYR 423
            |||||.|:|:|::.|....|.:.|||| :..|.|:||.:.:...:::..|.::|   ...|:.|.
Mouse   334 CKKKVPASKRFTIHRTSNVLTLSLKRFANFSGGKITKDVGYPEFLNIRPYMSQS---SGDPVMYG 395

  Fly   424 LVSMVTHLGASQHCGHYTAIGSTDTGSFYNFDDSYVRPIAMHSVCNTNAYIMFF----------E 478
            |.:::.|.|.|.|.|||........|.:|..:||.|....:..|.|..||::|:          |
Mouse   396 LYAVLVHSGYSCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLNQQAYVLFYLRIPGSKKSPE 460

  Fly   479 LDLSQAASPAANRPN-------------------------------------------------G 494
            ..:|:..:...:||.                                                 |
Mouse   461 GPVSRVGATLPSRPKVVPEHSKKSPGNGVVPSPLMAKRQDSVMMRKLPAPEEVGVPVSRNGSLPG 525

  Fly   495 VRLTNGHSTTPVPAATVS---SPSPTRFIGPQLPAGGANGYTNGNAQKTAIQFKQQNQQSPQNG- 555
            ::|.||.:....||.:.|   :|:||..  |.:..............::.......:|.||..|
Mouse   526 LKLQNGCAPAKTPAGSPSPRLTPTPTHM--PTILDEPGKKVKKSAPLQSLTTSPTTSQGSPGTGE 588

  Fly   556 ---LQLGTGKFQDT---AKPPLV------GAHAKGEATSAPTANGNKSSSPSSNSSSN------- 601
               .:.|:...:||   ..|.|:      |...|||.:......|:.|||...:|:|:
Mouse   589 SRSQRPGSWASRDTIFSTSPKLLARAITNGHRLKGEGSGVDLEKGDSSSSSPEHSASSDPAKAPQ 653

  Fly   602 -------HKSINQQQYLPISSDDEDIEDEMKPRPTTAQLPSMPNMTENHTEPKAKSPVK------ 653
                   |...:|....|.:...:.:.:.:..:....:.|::.:.|...|...:..|.|
Mouse   654 TAESRAAHACDSQGTNCPTAGHPKALLNGVDAKMVKLKSPALSSTTTEPTSLMSPPPAKKLALSA 718

  Fly   654 -------------IQVKTP-----VKTPLKSLVPYESAS-----EEEEAPLPNPRKRP-SGEDSS 694
                         |...:|     :.:|:|:..|..:::     ....||.|.|...| |...||
Mouse   719 KKASTLRRATGNDIGSPSPSAFCDLTSPMKATHPVVASTGPVSKTRTAAPAPRPSTHPHSASLSS 783

  Fly   695 ESDQESG----------------QTNGHSKTNGSHTNGSASSSVHVNNSKQKTD--------AID 735
            .|.:..|                |.|||. |:..|....||.::|..:.|:|..        .||
Mouse   784 SSAKPLGTSEPQSCRPSAWTPLPQVNGHF-TSHLHQLPEASEALHSPSKKRKKTPNGDPQRLGID 847

  Fly   736 EIF-------------KSLKKSADSD--------------------EDDDEEEPSI------QLT 761
            .:.             |..|:.::.:                    :.::..:|.:      .:.
Mouse   848 TLLPQCLRGAPAAARRKRKKRCSEGEGATAPKQEGQFQDQSWSSGSQKEEGTQPQVNGHQVSHIL 912

  Fly   762 NGWHPQKQSQSQSKAPP--SPKTPPSPAVIKSKTGIWKVTRNDEVDAIEDDVDVVVVEGSPVK-- 822
            :.:|...:.:.:.|...  |.:..||..:|:...        ..||..|.:....:.:....|
Mouse   913 DSYHVSSRKRRKRKRSEGLSQEATPSQDLIQHSC--------SPVDHSEPEARTELQKKKKKKRR 969

  Fly   823 ----IPTPNKNHRNPFSSSKPSTDSPATPGAKRQKLLNGSALKSHQQPRVGNGYQSNATSNGSTI 883
                .|..::..::|.....|.......|.......|....|...|.|.|    ..|.......:
Mouse   970 KRKPEPQQDEESKHPGDQRSPRPSVTPVPALSVNGHLPSDCLGLGQAPLV----TWNRDQEPDVV 1030

  Fly   884 NELLKQSY-RGYGSPVLSWNGKPAELEKELLVDAREQRQRDIDDDEENEMDRGRQRKVKSGSAKG 947
            ..||:.|. :.||..||:|:|:|:.:.::.:.|:|..|.:.:.||.:.|.|||:::|:|  ..|.
Mouse  1031 QALLQDSSDKAYGKKVLTWDGEPSAISQDAIKDSRLARTQTVVDDWDEEFDRGKEKKIK--KFKR 1093

  Fly   948 NNASNSTPGYNPFQEYEGQKR-WN 970
            ....|    :|.||:.:.::. |:
Mouse  1094 EKKRN----FNAFQKLQSRRNFWS 1113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scny	NP_729092.1	Peptidase_C19E	171..477	CDD:239126	115/308 (37%)
Usp36	XP_036012906.1	Peptidase_C19E	150..450	CDD:239126	116/309 (38%)
		PHA03247	<508..1018	CDD:223021	86/520 (17%)