Protein Alignment scny and USP17L4

DIOPT Version :10

• Sequence 1: NP_729092.1
• Gene: scny / 38648
• FlyBaseID: FBgn0260936
• Length: 1038
• Species: Drosophila melanogaster
• Sequence 2: NP_001243803.1
• Gene: USP17L4 / 645402
• HGNCID: 37176
• Length: 530
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 149/521 - (28%)
• Similarity: 236/521 - (45%)
• Gaps: 83/521 - (15%)

  Fly   142 NELPKPKRVLYPRENIRIGWKQSERKWQVGTGMINVGNTCYLNSTLQALLHIPALANWLVSEQAH 206
            ::|....|.|.|||.:.:   .|.|...||.|:.|:|||||.|::||.|.:...|||:::|.: |
Human    53 DDLAPVARQLAPREKLPL---SSRRPAAVGAGLQNMGNTCYENASLQCLTYTLPLANYMLSRE-H 113

  Fly   207 LADCNVAEPGSGCIICAMTKTLL-ATQSNQSAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLV 270
            ...|   :....|::|.|...:. |..|....::|    |:......|.  |:|||.||||.|.|
Human   114 SQTC---QRPKCCMLCTMQAHITWALHSPGHVIQP----SQALAAGFHR--GKQEDVHEFLMFTV 169

  Fly   271 EAMERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKAD 335
            :||::|.|   ..:|::|...|:||.:.|||||..||:::||.|:.:|.||..:.|:.|||:.|.
Human   170 DAMKKACL---PGHKQVDHHSKDTTLIHQIFGGCWRSQIKCLHCHGISDTFDPYLDIALDIQAAQ 231

  Fly   336 SLEDAFEGHFSRERLE-DMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFS-MIGNKLTKQIS 398
            |::.|.|.....|.|. :..|.|..|.::..|:...:|..:...|.:.||||| :.||||.|.:.
Human   232 SVKQALEQLVKPEELNGENAYHCGLCLQRAPASNTLTLHTSAKVLILVLKRFSDVAGNKLAKNVQ 296

  Fly   399 FKSRIDLSKYAARSQAAQAQPLTYRLVSMVTHLGASQHCGHYTAIGSTDTGSFYNFDDSYVRPIA 463
            :...:|:..|.::....   ||.|.|.:::.|.|.|.|.|:|.:......|.:|..||:.|...:
Human   297 YPECLDMQPYMSQQNTG---PLVYVLYAVLVHAGWSCHDGYYFSYVKAQEGQWYKMDDAEVTVCS 358

  Fly   464 MHSVCNTNAYIMFF---------ELDLSQAASPAA------NRPNGVRLTNGHSTTPVPAATVSS 513
            :.||.:..||::|:         ...:|:...|.|      :||    .|.|......|..
Human   359 ITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRP----ATQGELKRDHPCL---- 415

  Fly   514 PSPTRFIGPQLPAGGANGYTNGNAQKTAIQFK---QQNQQSPQNGLQLGTGKFQDTAKPPLVGAH 575
                     |:|....:.......:.|...:|   :||:..|:..::    |.:.|..|.::..|
Human   416 ---------QVPELDEHLVERATEESTLDHWKFPQEQNKMKPEFNVR----KVEGTLPPNVLVIH 467

  Fly   576 AKGEATSAPTANGNKSSSPSSNSS-SNHKSINQQQYLPISSDDEDIEDEMKPRPTTAQLPSMPNM 639
                  .:....|.|:..|...|| .|..|:|       |:|.|.:        .|..|.|:...
Human   468 ------QSKYKCGMKNHHPEQQSSLLNLSSMN-------STDQESM--------NTGTLASLQGR 511

  Fly   640 T 640
            |
Human   512 T 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scny	NP_729092.1	Peptidase_C19E	171..477	CDD:239126	105/308 (34%)
USP17L4	NP_001243803.1	Peptidase_C19E	79..373	CDD:239126	106/309 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	382..410		7/31 (23%)
		HABP4_PAI-RBP1	<431..454	CDD:461421	5/26 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	493..530		8/35 (23%)