Protein Alignment scny and USP29

DIOPT Version :10

• Sequence 1: NP_729092.1
• Gene: scny / 38648
• FlyBaseID: FBgn0260936
• Length: 1038
• Species: Drosophila melanogaster
• Sequence 2: NP_065954.1
• Gene: USP29 / 57663
• HGNCID: 18563
• Length: 922
• Species: Homo sapiens
• Alignment Length: 858
• Identity: 172/858 - (20%)
• Similarity: 288/858 - (33%)
• Gaps: 265/858 - (30%)

  Fly     1 MPVSMAVCETANVVNAALRESLGGNSSAGSSTDQAKSGEDTNGSLQNHIVANAKRILMAKIEYEE 65
            ||:.|:...|.  |...:.|:.||......|:| .::.||               ||.   |...
Human   146 MPLFMSKSPTH--VKKGILENQGGKGQNTLSSD-VQTNED---------------ILK---EDNP 189

  Fly    66 VPN--YHESVLENLKSKYIVIKPGNPGAINGFSGKNNTGKL-----VGANGHDNNGARKQAEHPN 123
            |||  |....|     |||.....||.::.... |:...||     ...||:.|......|....
Human   190 VPNKKYKTDSL-----KYIQSNRKNPSSLEDLE-KDRDLKLGPSFNTNCNGNPNLDETVLATQTL 248

  Fly   124 NQSHHIN-----HHNHQHPTSNPNELPKPKRVLYPRENIRIGWKQSERKWQVGTGMINVGNTCYL 183
            |..:.:.     .|:...|..|..::|                 ......|:..|..|:|||||:
Human   249 NAKNGLTSPLEPEHSQGDPRCNKAQVP-----------------LDSHSQQLQQGFPNLGNTCYM 296

  Fly   184 NSTLQALLHIPALANWLVSEQAHLADCNVAEPGS----GCIICAMTKTLLATQSNQSAVRPFLIY 244
            |:.||:|..||:.|:.|:::         ..|..    ..:|..:|:.|.......:.::..|:.
Human   297 NAVLQSLFAIPSFADDLLTQ---------GVPWEYIPFEALIMTLTQLLALKDFCSTKIKRELLG 352

  Fly   245 SKLKQICKHMVV---GRQEDAHEFLRFLVEAMERAYLMRFRNYKELDQL------VKE------- 293
            :..|.|.....:   ..|.||||||...::.::          :::::|      .||
Human   353 NVKKVISAVAEIFSGNMQNDAHEFLGQCLDQLK----------EDMEKLNATLNTGKECGDENSS 407

  Fly   294 -------------TTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKAD-----SLEDA 340
                         ..|:...|...|:..:.|.:|.|..:..:....|.:::.:..     |::::
Human   408 PQMHVGSAATKVFVCPVVANFEFELQLSLICKACGHAVLKVEPNNYLSINLHQETKPLPLSIQNS 472

  Fly   341 FEGHFSRERLEDMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFSMIGN-----KLTKQISFK 400
            .:..|..|.||   |.|:.||:| |...:.:..|....|.|.|||:| ..|     |..:|:...
Human   473 LDLFFKEEELE---YNCQMCKQK-SCVARHTFSRLSRVLIIHLKRYS-FNNAWLLVKNNEQVYIP 532

  Fly   401 SRIDLSKYAARSQAAQAQPLTYRLVSMVTHLGASQHCGHYTAIGSTDTGSFYNFDDSYVRPIAMH 465
            ..:.||.|...|   ...||.         |.:|...|.
Human   533 KSLSLSSYCNES---TKPPLP---------LSSSAPVGK-------------------------- 559

  Fly   466 SVCNTNAYIMFFELDLSQAASPAANRPNGVRLTNGHSTTPVPAATVSSPSPTRFIGPQLPAGGAN 530
              |..        |::||......|.|    ||        |:..::|.|....:.|..|
Human   560 --CEV--------LEVSQEMISEINSP----LT--------PSMKLTSESSDSLVLPVEP----- 597

  Fly   531 GYTNGNAQKTAIQ------FKQQNQQSPQNG--LQLGTGKFQDTA----KPPLVGAHAKGEATSA 583
               :.||.....|      .::|:|:..:||  |:.....|:|.|    :.|:..:.......|.
Human   598 ---DKNADLQRFQRDCGDASQEQHQRDLENGSALESELVHFRDRAIGEKELPVADSLMDQGDISL 659

  Fly   584 PTA---NGNKSSSPSSNSSSNH-KSINQ----QQYLPISSDDEDIEDEMKPRPTTAQLPSMPNMT 640
            |..   .|...|||.:.....| :.:.|    |:|...::..|...|.:     |.......:..
Human   660 PVMYEDGGKLISSPDTRLVEVHLQEVPQHPELQKYEKTNTFVEFNFDSV-----TESTNGFYDCK 719

  Fly   641 ENHTEPKAKSPVKIQVKTPVKTPLKSLVPYESASEE--EEAPLPNPRKRPSGEDSSESDQES--- 700
            ||.. |:....:..|::..::         ||..:|  ::||.|..||..:.|.:.|:..:|
Human   720 ENRI-PEGSQGMAEQLQQCIE---------ESIIDEFLQQAPPPGVRKLDAQEHTEETLNQSTEL 774

  Fly   701 -------------GQTNGHSKT--NGSHTNGSASS-----------------SV--HVNNSKQKT 731
                         |..|..:|.  :..:|.|.|..                 ||  |:.:|....
Human   775 RLQKADLNHLGALGSDNPGNKNILDAENTRGEAKELTRNVKMGDPLQAYRLISVVSHIGSSPNSG 839

  Fly   732 DAIDEIFKSLKKS 744
            ..|.:::...|::
Human   840 HYISDVYDFQKQA 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scny	NP_729092.1	Peptidase_C19E	171..477	CDD:239126	70/348 (20%)
USP29	NP_065954.1	PH_USP37_like	4..106	CDD:270122
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..196		13/54 (24%)
		UCH	286..552	CDD:425685	66/301 (22%)
		Peptidase_C19	<823..883	CDD:239072	6/30 (20%)