Protein Alignment scny and USP17L1

DIOPT Version :10

• Sequence 1: NP_729092.1
• Gene: scny / 38648
• FlyBaseID: FBgn0260936
• Length: 1038
• Species: Drosophila melanogaster
• Sequence 2: NP_001243802.1
• Gene: USP17L1 / 401447
• HGNCID: 37182
• Length: 530
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 145/527 - (27%)
• Similarity: 225/527 - (42%)
• Gaps: 95/527 - (18%)

  Fly   142 NELPKPKRVLYPRENIRIGWKQSERKWQVGTGMINVGNTCYLNSTLQALLHIPALANWLVSEQAH 206
            ::|....|.|.|||.:.:   .|.|...||.|:.|:|||||.|::||.|.:...|||:::|.: |
Human    53 DDLAPVARQLAPREKLPL---SSRRPAAVGAGLQNMGNTCYENASLQCLTYTLPLANYMLSRE-H 113

  Fly   207 LADCNVAEPGSGCIICAMTKTLL-ATQSNQSAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLV 270
            ...|   :....|::|.|...:. |..|....::|    |:......|.  |:|||.||||.|.|
Human   114 SQTC---QRPKCCMLCTMQAHITWALHSPGHVIQP----SQALAAGFHR--GKQEDVHEFLMFTV 169

  Fly   271 EAMERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKAD 335
            :||::|.|   ..:|::|...|:||.:.|||||..||:::||.|:.:|.||..:.|:.|||:.|.
Human   170 DAMKKACL---PGHKQVDHHCKDTTLIHQIFGGCWRSQIKCLHCHGISDTFDPYLDIALDIQAAQ 231

  Fly   336 SLEDAFEGHFSRERLE-DMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFS-MIGNKLTKQIS 398
            |::.|.|.....|.|. :..|.|..|.::..|:...:|..:...|.:.||||| :.||||.|.:.
Human   232 SVKQALEQLVKPEELNGENAYHCGLCLQRAPASNTLTLHTSAKVLILVLKRFSDVAGNKLAKNVQ 296

  Fly   399 FKSRIDLSKYAARSQAAQAQPLTYRLVSMVTHLGASQHCGHYTAIGSTDTGSFYNFDDSYVRPIA 463
            :...:|:..|.::....   ||.|.|.:::.|.|.|.|.|||.:........:|..||:.|...:
Human   297 YPECLDMQPYMSQQNTG---PLVYVLYAVLVHAGWSCHDGHYFSYVKAQEVQWYKMDDAEVTVCS 358

  Fly   464 MHSVCNTNAYIMFF---------ELDLSQAASPAA-------NRPNGVRLTNGHSTTPVP----- 507
            :.||.:..||::|:         ...:|:...|.|       .|.....|...|.....|
Human   359 IISVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRAKQGELKRDHPCLQAPELDEH 423

  Fly   508 ----AATVSSPSPTRFIGPQLPAGGANGYTNGNAQKTAIQFKQQNQQSPQNGLQLGTGKFQDTAK 568
                |...|:....:|:                        ::||:..|    :...||.:.|..
Human   424 LVERATQESTLDHWKFL------------------------QEQNKTKP----EFNVGKVEGTLP 460

  Fly   569 PPLVGAHAKGEATSAPTANGNKSSSPSSNSSSNHKSINQQQYLPISSDDEDIEDEMKPRPTTAQL 633
            |..:..|                .|.......||....|...|.:||.....::.|    .|..|
Human   461 PNALVIH----------------QSKYKCGMKNHHPEQQSSLLNLSSTTRTDQESM----NTGTL 505

  Fly   634 PSMPNMT 640
            .|:...|
Human   506 ASLQGRT 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scny	NP_729092.1	Peptidase_C19E	171..477	CDD:239126	105/308 (34%)
USP17L1	NP_001243802.1	Peptidase_C19E	79..373	CDD:239126	106/309 (34%)
		HABP4_PAI-RBP1	<417..454	CDD:461421	7/64 (11%)