DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scny and Usp17ld

DIOPT Version :9

Sequence 1:	NP_729092.1	Gene:	scny / 38648	FlyBaseID:	FBgn0260936	Length:	1038	Species:	Drosophila melanogaster
Sequence 2:	NP_001001559.2	Gene:	Usp17ld / 384701	MGIID:	3051372	Length:	545	Species:	Mus musculus

Alignment Length:	523	Identity:	138/523 - (26%)
Similarity:	229/523 - (43%)	Gaps:	104/523 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 WQV----GTGMINVGNTCYLNSTLQALLHIPALANWLVSEQAHLADCNVAEPGSGCIICAM---- 224
            |:.    |.|:.|.||:||||:.||.|.|.|.||::::|::.....|:    ..||.:|||
Mouse    43 WECPQGPGCGLQNTGNSCYLNAALQCLTHTPPLADYMLSQEYSQTCCS----PEGCKMCAMEAHV 103

  Fly   225 TKTLLATQSNQSAVRPFLIYSKLKQICKHMVVGRQEDAHEFLRFLVEAMERAYLMRFRNYKELDQ 289
            |::||.:.|. ..::|..|.:  ....||    :||||||||.|.:|.|..:.|   :.:::.:.
Mouse   104 TQSLLHSHSG-DVMKPSQILT--SAFHKH----QQEDAHEFLMFTLETMHESCL---QVHRQSEP 158

  Fly   290 LVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKADSLEDAFEGHFSRERLEDM- 353
            ..::::|:..||||..||:::||.|...|.|:..|.|:.|||..|.|:..|.   :..|:.|::
Mouse   159 TSEDSSPIHDIFGGLWRSQIKCLHCQGTSDTYDRFLDVPLDISSAQSVNQAL---WDTEKSEELR 220

  Fly   354 ---GYKCEGCKKKVSATKQFSLERAPITLCIQLKRFS-MIGNKLTKQISFKSRIDLSKYAARSQA 414
               .|.|..|::|:.|:|...:..||..|.:.||||| .:||||.:::|:...:||..|.::...
Mouse   221 GENAYYCGRCRQKMPASKTLHIHSAPKVLLLVLKRFSAFMGNKLDRKVSYPEFLDLKPYLSQPTG 285

  Fly   415 AQAQPLTYRLVSMVTHLGASQHCGHYTAIGSTDTGSFYNFDDSYVRPIAMHSVCNTNAYIMFF-- 477
            .   ||.|.|.:::.|.||:.|.|||.:......|.:|..||:.|....:.||.|.|||::|:
Mouse   286 G---PLPYALYAVLVHEGATCHSGHYFSYVKAGHGKWYKMDDTKVTSCDVTSVLNENAYVLFYVQ 347

  Fly   478 ELDLSQAASPAANRPNGVRLTNGHSTTPVPAATVSSPSPTRFIGPQLPAGGANGYTNGNAQKTAI 542
            :.||.:                                    :...:|.|..:...:...|....
Mouse   348 QTDLKE------------------------------------VSIDMPEGRIHEVLDPEYQLKKS 376

  Fly   543 QFKQQNQQSPQNGLQLGTGKFQDTAKP------PLVGAHAKGEATSAPTANGNKSSSPSSNS--- 598
            :.|:..::||..         :|..:|      ......:.||.......|..|:.....|:
Mouse   377 RRKKHKKKSPCT---------EDVGEPSKNREKKATKETSLGEGKVLQEKNHKKAGQKHENTKLV 432

  Fly   599 --SSNHKSINQQ----QYLPISSDDEDIEDEMKPRPTTAQLPS------MPNMTEN---HTEPKA 648
              ..||:.:.|:    :.||...:.:.....::.......||:      :|....|   .|..|.
Mouse   433 PQEQNHQKLGQKHRNNEILPQEQNHQKTGQSLRNTEGELDLPADAIVIHLPRSIANWGRDTPDKV 497

  Fly   649 KSP 651
            ..|
Mouse   498 NQP 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scny	NP_729092.1	Peptidase_C19E	171..477	CDD:239126	109/314 (35%)
		UCH	172..477	CDD:278850	108/313 (35%)
		Asp-B-Hydro_N	<617..>731	CDD:191249	7/44 (16%)
Usp17ld	NP_001001559.2	Peptidase_C19E	50..346	CDD:239126	110/315 (35%)
		UCH	51..345	CDD:278850	108/313 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..443		13/84 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..545
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	209	1.000	Domainoid score	I2834
eggNOG	1	0.900	-	-		E1_KOG1865
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000177
OrthoInspector	1	1.000	-	-		otm44363
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24006
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910